Bioactive aromatic butenolides from a mangrove sediment originated fungal species, Aspergillus terreus SCAU011

Bao, Jie; Li, Xiu-Xiu; Zhu, Kongkai; He, Fei; Wang, Yinyin; Yu, Jin‐Hai; Zhang, Xiaoyong; Zhang, Hua

doi:10.1016/j.fitote.2021.104856

Cited by 11 publications

(6 citation statements)

References 31 publications

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“…[29] Marine fungi demonstrate multifunctional bio-activity, [30] and the secondary metabolites from marine fungi are known to possess antitumor, antibacterial, antiviral and anti-inflammatory activities. [31] Recently, our lab identified a new compound from a mangrove sediment originated fungal species, Aspergillus terreus SCAU011, [11] but the bio-activity of asperbutenolide A against clinical microbes remains unknown. In the present study, we first systematically analyzed the antibacterial activity of asperbutenolide A against common pathogenic microbes and found that asperbutenolide A displayed ideal antibacterial activity against MRSA at 4-8 μg/mL.…”

Section: Discussionmentioning

confidence: 99%

“…The fungi fermentation, extraction and metabolite purification were as our previously protocol. [11] Strains, growth and agents S. aureus, E. faecium, E. coli, P. aeruginosa, A. baumannii J71 and K. pneumonia J4 were routinely cultured in MH medium at 35 °C. [22] The resistant stains of candida.albicans and candida.tropical were collected from clinical department.…”

Section: Asperbutenolide a Preparationmentioning

confidence: 99%

“…reported five new butenolides with well antibacterial activities [10] . Meanwhile, our lab recently identified an unusual aromatic butenolide, asperbutenolide A, with antimicrobial and antioxidant properties from the marine fungus, from Aspergillus terreus SCAU011 [11] . However, the bio‐activity and sterilization mechanism of asperbutenolide A against clinical pathogenic microbes remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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Biological Activity and Sterilization Mechanism of Marine Fungi‐derived Aromatic Butenolide Asperbutenolide A Against Staphylococcus aureus

Jiang,

Wang,

Zhang

et al. 2024

Chemistry & Biodiversity

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marine fungi represent a huge untapped resource of natural products. The bio‐activity of a new asperbutenolide A from marine fungus Aspergillus terreus was not well known. In the present study, the minimum inhibitory concentration (MIC) and RNA‐Sequencing were used to analyze the bio‐activity and sterilization mechanism of asperbutenolide A against clinical pathogenic microbes. The results showed that the MICs of asperbutenolide A against methicillin‐resistant Staphylococcus aureus (MRSA) were 4.0‐8.0 μg/mL. The asperbutenolide A present poor bio‐activity against with candida. The sterilization mechanism of asperbutenolide A against MRSA showed that there were 1426 differentially‐expressed genes (DEGs) between the groups of MRSA treated with asperbutenolide A and negative control. Gene Ontology (GO) classification analysis indicated that the DEGs were mainly involved in cellular process, metabolic process, cellular anatomical entity, binding, catalytic activity, etc. Kyoto Encyclopedia of Genes and Genomes (KEGG) classification analysis showed that these DEGs were mainly enriched in amino acid metabolism, carbohydrate metabolism, membrane transport, etc. Moreover, qRT‐PCR showed similar trends in the expressions of argF, ureA, glmS and opuCA with the RNA‐Sequencing. These results indicated that asperbutenolide A was with ideal bio‐activity against with MRSA and could be as a new antibacterial agent.

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Section: Discussionmentioning

confidence: 99%

Section: Asperbutenolide a Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biological Activity and Sterilization Mechanism of Marine Fungi‐derived Aromatic Butenolide Asperbutenolide A Against Staphylococcus aureus

Jiang,

Wang,

Zhang

et al. 2024

Chemistry & Biodiversity

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“…A. terreus is a producer of many aromatic secondary metabolites. The main secondary metabolites are various derivatives of asperlides and aspernolides, butyrolactones and butenolides and terrusnolides, which can potentially be the source of the unique composition of chromophores of A. terreus [33].…”

Section: Fluorescence Excitation/emission Matrix (Eem) Spectroscopymentioning

confidence: 99%

Excitation-Dependent Fluorescence Helps to Indicate Fungal Contamination of Aquatic Environments and to Differentiate Filamentous Fungi

et al. 2022

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Fungal contamination of aquatic environments can lead to an adverse impact on the environment and human health. (1) The search for fast, inexpensive and appropriate methods for detection of fungi is very moving rapidly due to their significant impact on ecosystem functions and human health. (2) We focused on examination of fluorescence proxies able to distinguish chromophoric matter occurring in different fungi. Spectroscopic studies were performed on five strains of filamentous fungi: Trichoderma harzianum, Fusarium solani, Alternaria alternata, Cladosporium cladosporioides and Aspergillus terreus. (3) The results showed that most of the fungal autofluorescence was emitted by amino acids, melanin-like compounds, NAD(P)H and flavins. The spectra of five fungal species cultivated as planktonic or surface-associated forms turned out to be different. Protein fluorescence can be used to detect general microbial contamination. Presence of excitation wavelength dependent mode and the “blue shift” of fluorescence (emission bands 400–500 nm) can be suggested as specific feature of fluorescence of fungal melanin-containing samples. (4) The determination based on fluorescence spectra obtained at a certain excitation/emission wavelengths pair and at whole excitation-emission matrices (EEMs) coupled to principal component analysis (PCA) algorithms as a tool of improving detection capabilities can be suggested to enable fast and inexpensive monitoring of fungal contamination of aquatic environments.

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“…4 In addition, A. terreus have been reported as the rich source of several bioactive compounds. For example, α-glucosidase inhibitory butanolide analogues, 5 cytotoxic alkaloids, 6 nitric oxide production inhibitory dihydrobenzofuran derivatives, 7 and β-site amyloid precursor protein-cleaving enzyme 1 inhibitory meroterpenoids 1 have been reported as the secondary metabolites of A. terreus. On our ongoing research program for the discovery of new cancer treatment agents, we previously reported the Wnt signal inhibitor from Lindera umbellate, 8 the anti-proliferative agents against cancer stem cells from Petasites japonicus, 9 and the heat shock protein (HSP) expression inhibitors from Hypericum erectum.…”

mentioning

confidence: 99%

Chemical Structures and Cell Death Inducing Activities of the Metabolites of Aspergillus terreus

Μatsumoto¹,

Watanabe²,

Okayama³

et al. 2023

HETEROCYCLES

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A new steroid, terreus steroid (1), and eight known compounds (2-9) have been isolated from the airborne-derived fungus Aspergillus terreus. The structure of terreus steroid (1) was elucidated based on the chemical/physicochemical evidence. The cell death-inducing activities of the isolated compounds with or without Adriamycin (ADR) were observed using time-lapse cell imaging. Among the isolated compounds, terreus steroid (1) and territrem B (3) significantly reduced the number of mitotic entry cells at 60 μM. In addition, terreus steroid (1), territrem C (2), territrem B (3), epi-aszonalenin A (5), and methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate (6) significantly increased the number of dead cells on Adriamycin-treated HeLa cells.

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Bioactive aromatic butenolides from a mangrove sediment originated fungal species, Aspergillus terreus SCAU011

Cited by 11 publications

References 31 publications

Biological Activity and Sterilization Mechanism of Marine Fungi‐derived Aromatic Butenolide Asperbutenolide A Against Staphylococcus aureus

Biological Activity and Sterilization Mechanism of Marine Fungi‐derived Aromatic Butenolide Asperbutenolide A Against Staphylococcus aureus

Excitation-Dependent Fluorescence Helps to Indicate Fungal Contamination of Aquatic Environments and to Differentiate Filamentous Fungi

Chemical Structures and Cell Death Inducing Activities of the Metabolites of Aspergillus terreus

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