Bioactive Amino-Quinazolines: Synthesis and Therapeutic Applications
Lucas Franco,
Pedro Pinheiro,
Maria Letícia Barbosa
Abstract:The amino-quinazoline scaffold stands out as a privileged structure in Medicinal Chemistry, due to its pleiotropic pharmacological profile. It has been explored in the design and development of novel drug candidates for several therapeutic applications, including antihypertensive, antiinflammatory, antipsychotic, anti-Alzheimer, anticancer, antiviral, antibiotic, and antiparasitic treatments, among others. The therapeutic value of amino-quinazoline drugs was first demonstrated with the use of alpha 1-adrenocep… Show more
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