Bioactive 1,4-dihydroisonicotinic acid derivatives prevent oxidative damage of liver cells

Borović, Suzana; Tirzītis, G.; Tirzīte, Dace; Čipak, Ana; Khoschsorur, G.; Waeg, Georg; Tatzber, Franz; Ščukaneć-Špoljar, Mira; Žarković, Neven

doi:10.1016/j.ejphar.2006.03.004

Cited by 13 publications

(14 citation statements)

References 36 publications

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“…MDA quantification by HPLC has shown good inter-laboratory validity in replicate human EDTA treated plasma samples sent to multiple labs (202). HNE can also be reliably detected in plasma and urine using both HPLC (203) methods and ELISAs (204). …”

Section: Reactive Oxygen and Nitrogen Speciesmentioning

confidence: 99%

A Review of the Application of Inflammatory Biomarkers in Epidemiologic Cancer Research

Brenner

Scherer

Muir

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

141

123

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Inflammation is a facilitating process for multiple cancer types. It is believed to affect cancer development and progression through several etiologic pathways including increased levels of DNA adduct formation, increased angiogenesis and altered anti-apoptotic signaling. This review highlights the application of inflammatory biomarkers in epidemiologic studies and discusses the various cellular mediators of inflammation characterizing the innate immune system response to infection and chronic insult from environmental factors. Included is a review of six classes of inflammation-related biomarkers: cytokines/chemokines, immune-related effectors, acute phase proteins, reactive oxygen and nitrogen species, prostaglandins and cyclooxygenase-related factors, and mediators such as transcription factors and growth factors. For each of these biomarkers we provide a brief overview of the etiologic role in the inflammation response and how they have been related to cancer etiology and progression within the literature. We provide a discussion of the common techniques available for quantification of each marker including strengths, weaknesses and potential pitfalls. Subsequently, we highlight a few under-studied measures to characterize the inflammatory response and their potential utility in epidemiologic studies of cancer. Finally, we suggest integrative methods for future studies to apply multi-faceted approaches to examine the relationship between inflammatory markers and their roles in cancer development.

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Section: Reactive Oxygen and Nitrogen Speciesmentioning

confidence: 99%

A Review of the Application of Inflammatory Biomarkers in Epidemiologic Cancer Research

Brenner

Scherer

Muir

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

141

123

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“…The poly-hydroquinolines possessing a bioactive 1, 4-dihydropyridine moiety also have an important biological activities such as vasodilator, bronchodilator, anti-atherosclerotic, antitumor, gero-protective, hepatoprotective and anti-diabetic activity 24 . Although the antioxidant activities of quinolines and 1, 4-dihydropyridines 25,26 have been extensively studied, the poly-hydroquinolines are not well explored. 4-Aryl-1, 4-dihydropyridines are analogues of NADH coenzymes, which have been explored for their calcium channel activity 27 .…”

Section: Ijpsr (2018) Volume 9 Issue 1 (Research Article)mentioning

confidence: 99%

Untitled

2018

IJPSR

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4-Aryl-hexahydroquinolines in vitro antioxidant properties were evaluated by spectrophotometric method. This method is based on the charge transfer complex which is formed between 4-arylhexahydroquinolines and chloranil. AM1 and PM3 semi empirical methods were used to estimate different physicochemical parameters. The antioxidant activity was correlated with these physicochemical parameters and different QSAR models were generated. Docking studies were also performed in the active site of prenyl transferase to identify the structural features of the antioxidants. Docking scores with appreciable binding energy values also exactly correlated with the experimental activity. The chemscore estimated by Gold Software was found to have a good correlation with the experimental activity. The Docking and QSAR results reveal that the electron donating substituents on benzene ring were responsible to improve the antioxidant activity of the molecules.

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“…16,32,33 Briefly, an ethanol solution (200 μL) of 100 μM diphenyl-picryl hydrazide (Aldrich, USA) was incubated at 30 °C with 1 μL of compound or Trolox solutions in deionized H2O. The final concentration of compounds was 100 μM.…”

Section: Dpph Radical Scavenging Assaymentioning

confidence: 99%

“…16,34,35 The procedure to prepare the ABST + stock solution was modified slightly. Sufficient amounts of the diammonium salts of ABTS + (Sigma, USA) and K2S2O8 (Sigma, USA) were dissolved in 2.0 mL water to achieve concentrations of 4.00 and 1.41 mM, respectively.…”

Section: Abst + Radical Cation Scavenging Assaymentioning

confidence: 99%

“…[3][4][5] The antioxidants can minimize or inhibit the oxidative damage through interrupting the free-radical formation or terminating the 11 The polyhydroquinolines possessing a bioactive 1,4-dihydropyridine moiety also have important biological properties. [12][13][14] Although the antioxidant activities of quinolines and 1,4-dihydropyridines 15,16 have been extensively studied, the polyhydroquinolines are not well explored. The synthesis and antioxidant evaluation of new polyhydroquinolines, therefore, is included as part of our medicinal chemistry project aiming to identify a new class of antioxidants.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and antioxidant evaluation of novel 4-aryl-hexahydroquinolines from lignin

Yang¹,

Zhang²,

Zhou³

et al. 2011

Arkivoc

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A series of 4-aryl-hexahydroquinolines were prepared by Hantzsch reaction using aromatic aldehydes obtained from lignin, 1,3-cyclohexanediones, β-ketoesters and ammonium carbonate. The antioxidant properties of compounds 5a-c and 5g-i were evaluated by two methods: scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and scavenging effect on 2,2′-azino-bis(3-ethylenzothiazoline-sulfonic acid) diammonium salt (ABTS + ) radical. The results show that the compounds containing a methoxy moiety exhibit good activities. The study suggests that some synthesized compounds may serve as promising leads for the treatment against tumors or other free radical-related diseases.

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Bioactive 1,4-dihydroisonicotinic acid derivatives prevent oxidative damage of liver cells

Cited by 13 publications

References 36 publications

A Review of the Application of Inflammatory Biomarkers in Epidemiologic Cancer Research

A Review of the Application of Inflammatory Biomarkers in Epidemiologic Cancer Research

Untitled

Synthesis and antioxidant evaluation of novel 4-aryl-hexahydroquinolines from lignin

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