Bioactivation of New Harmonic Titanium Alloy to Improve and Control Cellular Response and Differentiation

Rangel, André; Lam, Mylan; Hocini, A.; Humblot, Vincent; Ameyama, Kei; Migonney, Véronique; Dirras, G.; Falentin‐Daudre, Céline

doi:10.1016/j.irbm.2023.100771

Cited by 2 publications

(2 citation statements)

References 47 publications

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“…For example, Boix-Lemonche et al [ 19 ] immobilized an antibacterial peptide on a pretreated silanized titanium surface. Rangel et al [ 20 ] grafted poly (sodium styrene sulfonate) with a thiol end group onto a titanium surface with an alkene group via a thiolene click reaction. Methling et al [ 21 ] used phosphonic acid as a linker to graft biopolymers onto titanium oxide surfaces.…”

Section: Introductionmentioning

confidence: 99%

A Water-Based Biocoating to Increase the Infection Resistance and Osteoconductivity of Titanium Surfaces

Luo,

Chang,

Chang

et al. 2024

IJMS

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As the population ages, the number of patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) continues to increase. Infections after primary arthroplasty are rare but have high rates of morbidity and mortality, as well as enormous financial implications for healthcare systems. Numerous methods including the use of superhydrophobic coatings, the incorporation of antibacterial agents, and the application of topographical treatments have been developed to reduce bacterial attachment to medical devices. However, most of these methods require complex manufacturing processes. Thus, the main purpose of this study was to apply biocoatings to titanium (Ti) surfaces to increase their infection resistance and osteoconductivity via simple processes, without organic reagents. We modified titanium surfaces with a combination of aminomalononitrile (AMN) and an antibiotic-loaded mesoporous bioactive glass (MBG) and evaluated both the antibacterial effects of the coating layer and its effect on osteoblast proliferation and differentiation. The properties of the modified surface, such as the hydrophilicity, roughness, and surface morphology, were characterized via contact angle measurements, atomic force microscopy, and scanning electron microscopy. The cell proliferation reagent WST-1 assay and the alkaline phosphatase (ALP) assay were used to determine the degrees of adhesion and differentiation, respectively, of the MG-63 osteoblast-like cells on the surface. Antimicrobial activity was evaluated by examining the survival rate and inhibition zone of Escherichia coli (E. coli). The AMN coating layer reduced the water contact angle (WCA) of the titanium surface from 87° ± 2.5° to 53° ± 2.3° and this change was retained even after immersion in deionized water for five weeks, demonstrating the stability of the AMN coating. Compared with nontreated titanium and polydopamine (PDA) coating layers, the AMN surface coating increased MG-63 cell attachment, spreading, and early ALP expression; reduced E. coli adhesion; and increased the percentage of dead bacteria. In addition, the AMN coating served as an adhesion layer for the subsequent deposition of MBG-containing antibiotic nanoparticles. The synergistic effects of the AMN layer and antibiotics released from the MBG resulted in an obvious E. coli inhibition zone that was not observed in the nontreated titanium group.

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Section: Introductionmentioning

confidence: 99%

A Water-Based Biocoating to Increase the Infection Resistance and Osteoconductivity of Titanium Surfaces

Luo,

Chang,

Chang

et al. 2024

IJMS

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“…Titanium alloys are widely used in aerospace, marine, automotive, and biomedical fields because of their high strength, high temperature resistance, corrosion resistance, non-toxicity, and good weldability [ 1 , 2 ]. With the development of the aerospace, marine and automotive industries in recent years, the requirements for excellent mechanical properties, such as a high strength, high toughness and fatigue resistance, are becoming urgent.…”

Section: Introductionmentioning

confidence: 99%

Effect of Microstructure on High-Speed Tensile Mechanical Properties of Ti-1300 Alloy

Zhang

Liu

2023

Materials

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It is usually required that Ti-1300 alloys be able to withstand a greater load under special conditions, such as the controllable collision of a space shuttle and rapid collision of an automobile. Because of a good combination of strength and toughness, Ti-1300 alloys are widely applied in the aerospace industry. However, during the service process, the alloy components inevitably bear extreme loads. This paper uses high-speed tensile technology to systematically study the effects of different strain rates on the deformation of the microstructure and deformation mechanism of Ti-1300 alloys and to clarify a relation between the microstructure and mechanical properties. The results show that no phase transformation occurs during the high-speed tensile process at strain rates of 200 s−1 and 500 s−1. The deformation mechanism is mainly due to dislocation slip. The fracture mode is ductile fracture at the two strain rates, due to the connection between micro-voids promoted by dislocation slip. The ultimate tensile strengths are 1227 MPa and 1368 MPa, the yield strengths are 1050 MPa and 1220 MPa, and the elongations are 11.3% and 10.4%, respectively. The present results provide theoretical guidance for the further application of metastable β titanium alloys in working environments with high strain rates.

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Bioactivation of New Harmonic Titanium Alloy to Improve and Control Cellular Response and Differentiation

Cited by 2 publications

References 47 publications

A Water-Based Biocoating to Increase the Infection Resistance and Osteoconductivity of Titanium Surfaces

A Water-Based Biocoating to Increase the Infection Resistance and Osteoconductivity of Titanium Surfaces

Effect of Microstructure on High-Speed Tensile Mechanical Properties of Ti-1300 Alloy

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