Bioaccumulation of silver and its effects on biochemical parameters and histological alterations in an Indian major carp Labeo rohita

Shobana, Chellappan; Rangasamy, Basuvannan; Hemalatha, Devan; Ramesh, Mathan

doi:10.1016/j.enceco.2020.10.006

Cited by 11 publications

(5 citation statements)

References 52 publications

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“…Silver residues were highly detected in the liver, and the current findings indicate a primitive role of the liver in the detoxification of silver and AgNP-induced liver cell injury. Similar results were observed in Clarias gariepinus and Indian major carp Labeo rohita , in which AgNPs were highly detected in the liver even after 15 days of recovery [ 121 , 122 ].…”

Section: Discussionsupporting

confidence: 78%

“…Such variations may depend on species-specific differences or variable experimental conditions. For instance, 15 days of exposure to silver led to its considerable accumulation in the liver of C. gariepinus [ 121 , 122 ]. Treatment of the freshwater rainbow trout with AgNPs resulted in the accumulation of great quantities of silver in the liver, intestine, muscles, and gills [ 124 ].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Quercetin Nanoparticles on Hepatic and Intestinal Enzymes and Stress-Related Genes in Nile Tilapia Fish Exposed to Silver Nanoparticles

et al. 2023

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Recently, nanotechnology has become an important research field involved in the improvement of animals’ productivity, including aquaculture. In this field, silver nanoparticles (AgNPs) have gained interest as antibacterial, antiviral, and antifungal agents. On the other hand, their extensive use in other fields increased natural water pollution causing hazardous effects on aquatic organisms. Quercetin is a natural polyphenolic compound of many plants and vegetables, and it acts as a potent antioxidant and therapeutic agent in biological systems. The current study investigated the potential mitigative effect of quercetin nanoparticles (QNPs) against AgNPs-induced toxicity in Nile tilapia via investigating liver function markers, hepatic antioxidant status, apoptosis, and bioaccumulation of silver residues in hepatic tissue in addition to the whole-body chemical composition, hormonal assay, intestinal enzymes activity, and gut microbiota. Fish were grouped into: control fish, fish exposed to 1.98 mg L−1 AgNPs, fish that received 400 mg L−1 QNPs, and fish that received QNPs and AgNPs at the same concentrations. All groups were exposed for 60 days. The moisture and ash contents of the AgNP group were significantly higher than those of the other groups. In contrast, the crude lipid and protein decreased in the whole body. AgNPs significantly increased serum levels of ALT, AST, total cholesterol, and triglycerides and decreased glycogen and growth hormone (*** p < 0.001). The liver and intestinal enzymes’ activities were significantly inhibited (*** p < 0.001), while the oxidative damage liver enzymes, intestinal bacterial and Aeromonas counts, and Ag residues in the liver were significantly increased (*** p < 0.001, and * p < 0.05). AgNPs also significantly upregulated the expression of hepatic Hsp70, caspase3, and p53 genes (* p < 0.05). These findings indicate the oxidative and hepatotoxic effects of AgNPs. QNPs enhanced and restored physiological parameters and health status under normal conditions and after exposure to AgNPs.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Effect of Quercetin Nanoparticles on Hepatic and Intestinal Enzymes and Stress-Related Genes in Nile Tilapia Fish Exposed to Silver Nanoparticles

et al. 2023

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“…Notably, ALT is primarily domiciled in the liver, making it the most sensitive marker of liver damage [ 35 , 36 ]. Even though AST is found in the liver, kidney, and cardiac and skeletal muscles, determining its levels coupled to ALT is vital in diagnosing cell damage [ 37 ]. We observed no significant alterations in ALT and AST enzyme levels in experimental rats treated with the aqueous shoot extract of Y. alpina, and the measured levels were comparable to those of control group rats.…”

Section: Discussionmentioning

confidence: 99%

“…The liver and kidney are prone to drug- or toxicant-induced cell damage due to their fundamental roles in metabolism and excretion [ 35 , 37 ]. The spleen is the principal organ of the lymphatic system, which plays an essential role in producing and manipulating crucial immunity elements.…”

Section: Discussionmentioning

confidence: 99%

“…The spleen is the principal organ of the lymphatic system, which plays an essential role in producing and manipulating crucial immunity elements. Intact drugs, exogenous chemical toxicants, or their metabolites might cause toxicity to these organs (liver, kidney, and spleen) depending on their dose and period of exposure, resulting in characteristic histopathological changes [ 37 ]. Damage to these organs may result in deleterious consequences, including death.…”

Section: Discussionmentioning

confidence: 99%

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Subacute Toxicity Effects of the Aqueous Shoot Extract of Yushania alpina (K. Schum.) W.C.Lin in Sprague Dawley Rats: An Appraisal of Its Safety in Ethnomedicinal Usage

Wanjiru

Maitho

Mbaria

et al. 2022

Journal of Toxicology

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Plant-based medicines have effectively managed several ailments in humans and animals since prehistoric times. However, the pharmacologic efficacy and safety of many plants currently used in traditional medicine have not been explored empirically, which raises serious public health concerns, derailing further research and their integration into the conventional healthcare system. Despite the longstanding ethnomedicinal usage of Yushania alpina shoot extract to treat inflammation, microbial infections, and diarrhoea, among other diseases, there is insufficient scientific data to appraise its toxicity profile and safety. Accordingly, we investigated the subacute toxicity of the aqueous shoot extract of Y. alpina in Sprague Dawley rats (both sexes) for 28 days based on the Organisation for Economic Cooperation and Development guideline 407. In this study, all the experimental rats treated orally with 40 mg/Kg BW, 200 mg/Kg BW, and 1000 mg/Kg BW of the aqueous shoot extract of Y. alpina remained normal, like the control group rats, and did not show any clinical signs of subacute toxicity, and no morbidity or mortality was recorded. Besides, the weekly body weight gains and the haematological and biochemical parameters of experimental rats orally administered with the studied plant extract at the tested doses and in the control group were comparable ( P > 0.05 ). No pathologic alterations in internal organs were observed following necroscopy. Further, the differences in weights of the liver, kidney, and spleen of experimental rats which were subacutely treated with the studied plant extract and the control rats were insignificant ( P > 0.05 ). Moreover, no histopathological changes were observed in tissue sections of the liver, kidney, and spleen obtained from all the experimental rats. Our findings demonstrate that the aqueous shoot extract of Y. alpina may be safe as it does not elicit subacute toxicity in Sprague Dawley rats. Further toxicological and pharmacological studies using other model animals and in clinical setups are encouraged to fully appraise the efficacy and safety of the studied plant extract.

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Ferrous Iron Overload Evokes Thyroidal and Interrenal Activation, Shifts Metabolite Pattern and Reverses Hepatic Ion Transporter Activities in Salinity-Acclimated Air-Breathing Fish (Anabas testudineus) Bloch

Gayathry

Peter

2021

Proc Zool Soc

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Bioaccumulation of silver and its effects on biochemical parameters and histological alterations in an Indian major carp Labeo rohita

Cited by 11 publications

References 52 publications

Effect of Quercetin Nanoparticles on Hepatic and Intestinal Enzymes and Stress-Related Genes in Nile Tilapia Fish Exposed to Silver Nanoparticles

Effect of Quercetin Nanoparticles on Hepatic and Intestinal Enzymes and Stress-Related Genes in Nile Tilapia Fish Exposed to Silver Nanoparticles

Subacute Toxicity Effects of the Aqueous Shoot Extract of Yushania alpina (K. Schum.) W.C.Lin in Sprague Dawley Rats: An Appraisal of Its Safety in Ethnomedicinal Usage

Ferrous Iron Overload Evokes Thyroidal and Interrenal Activation, Shifts Metabolite Pattern and Reverses Hepatic Ion Transporter Activities in Salinity-Acclimated Air-Breathing Fish (Anabas testudineus) Bloch

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