Bioaccumulation of perfluoroalkyl substances in marine echinoderms: Results of laboratory-scale experiments with Holothuria tubulosa Gmelin, 1791

Martín, Julia; Hidalgo, F.; García-Córcoles, María Teresa; Ibáñez-Yuste, Alejandro José; Alonso, Esteban; Vı́lchez, J.L.; Zafra-Gómez, Alberto

doi:10.1016/j.chemosphere.2018.10.037

Cited by 33 publications

(20 citation statements)

References 79 publications

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“…Higher levels of accumulation were noted in the small intestine compared to colon tissues. In vivo exposure studies conducted in the past have also demonstrated a significant amount of PFOA, as well as the accumulation of other PFAS compounds in intestinal tissues compared to other organs [ 37 , 39 , 40 ]. The current study is in line with the studies conducted in the past.…”

Section: Discussionmentioning

confidence: 99%

“…To explore the epigenetic mechanisms that can cause gene expression changes in the small intestine and colon tissues exposed to PFOA, we specifically studied the mRNA expression changes of genes involved in DNA methylation mechanisms. Various studies published recently indicate a number of mechanisms by which epigenetic changes regulate intestinal development [ 46 ] and cause various intestinal disorders [ 40 , 48 ], thus providing the opportunities to identify new epigenetic biomarkers as treatment targets.…”

Section: Discussionmentioning

confidence: 99%

“…These evaluations suggest that direct environmental and occupational exposure to PFOA can possibly lead to epigenetic alterations in the intestinal tissues. These methylation anomalies can be of potential significance in the development of human pathologies as is evident from previous studies in animal models, which showed their association with inflammatory bowel disease (IBD) [ 45 ], compromised intestinal development [ 46 ], intestinal adenomas [ 47 ], colorectal cancer [ 40 ], intestinal inflammation [ 48 ], and inflammatory bowel disease including Crohn’s disease [ 49 , 50 ]. The epigenetic changes can also lead to overexpression and inhibition of various TJ genes which can promote tumorigenic and metastatic properties of gastric cancer cells [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…The increased bioaccumulation potential of PFASs in the intestine compared to gonads was also found in other organisms such as Holothuria tubulosa . Accumulation in intestinal tissue was dependent on the perfluoroalkyl chain lengths, thus PFOA and perfluorooctane sulfonate (PFOS) were found to have higher bioaccumulation potential than shorter-chain compounds [ 40 ]. It has been reported that PFOA levels in serum were positively correlated to ulcerative colitis in humans [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…The changes in the DNA methylation patterns were also found to be linked with alteration of disease-related genes in inflammatory bowel disease (IBD) and inhibition of various tumor suppressor genes in cancers [ 45 ]. Various studies published recently indicate the number of mechanisms by which epigenetic changes regulate intestinal development [ 46 ] and cause various intestinal disorders such as intestinal adenomas [ 47 ], colorectal cancer [ 40 ], intestinal inflammation [ 48 ], and inflammatory bowel disease including Crohn’s disease [ 49 , 50 ]. The role of epigenetics in the regulation of tight junction genes is also evident from the literature.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Perfluorooctanoic Acid on the Epigenetic and Tight Junction Genes of the Mouse Intestine

Rashid

Ahmad

Irudayaraj

2020

Toxics

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Perfluorooctanoic acid (PFOA) has been implicated in various toxicities including neurotoxicity, genotoxicity, nephrotoxicity, epigenetic toxicity, immunotoxicity, reproductive toxicity, and hepatotoxicity. However, information on the accumulation of PFOA in the intestine and its toxic effects on intestinal epigenetics and tight junction (TJ) genes is sparse. CD1 mice were dosed with PFOA (1, 5, 10, or 20 mg/kg/day) for 10 days, and its accumulation and induced alterations in the expression of epigenetic and tight junction genes in the small intestine and colon were evaluated using LC–MS and qPCR techniques. PFOA reduced the expression levels of DNA methyltransferases (Dnmt1, Dnmt3a, Dnmt3b) primarily in the small intestine whereas, in the colon, a decrease was observed only at high concentrations. Moreover, ten-eleven translocation genes (Tet2 and Tet3) expression was dysregulated in the small intestine, whereas in the colon Tets remained unaffected. The tight junction genes Claudins (Cldn), Occludin (Ocln), and Tight Junction Protein (Tjp) were also heavily altered in the small intestine. TJs responded differently across the gut, in proportion to PFOA dosing. Our study reveals that PFOA triggers DNA methylation changes and alters the expression of genes essential for maintaining the physical barrier of intestine, with more profound effects in the small intestine compared to the colon.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of Perfluorooctanoic Acid on the Epigenetic and Tight Junction Genes of the Mouse Intestine

Rashid

Ahmad

Irudayaraj

2020

Toxics

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Uptake, Tissue Distribution, and Elimination of 8:2 Polyfluoroalkyl Phosphate Diesters in Mytilus galloprovincialis

Cui

Tan

Chen

et al. 2021

Enviro Toxic and Chemistry

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Although the distribution of 8:2 polyfluoroalkyl phosphate diester (8:2 diPAP) in aquatic environments has been reported, details on its uptake, tissue specificity, and elimination in bivalve mollusks remain to be clarified. The present study is the first report on the accumulation and elimination of 8:2 diPAP in mussels (Mytilus galloprovincialis). The tissue-specific accumulation and depuration of 8:2 diPAP and its metabolites were investigated via semistatic seawater exposure (8:2 diPAP at a nominal concentration of 10 μg/L), through water-borne exposure with static daily renewal over a 72-h exposure period and a 360-h depuration period. The digestive gland was found to be the target organ where accumulation and biotransformation primarily occur. The bioaccumulation factor values (mL/g dry wt) in different organs were in the following order: digestive gland (1249) > adductor muscle (315) > gills (289) > gonad (82.9) > mantle (33.0). Moreover, the distribution of 8:2 diPAP among tissues may be related to the total protein content. The 8:2 diPAP tended to be excreted in feces. The compounds 8:2 fluorotelomer carboxylic acid, 8:2 fluorotelomer unsaturated carboxylic acid, 7:3 fluorotelomer carboxylic acid, perfluorooctanoic acid, and perfluoroheptanoic acid were detected and quantified as phase I metabolites, and the concentration of all phase I metabolites relative to the 8:2 diPAP concentration (72 h) was 0.304 mol%. A phase II metabolite, 8:2 fluorotelomer alcohol conjugated with sulfate, was detected but not quantitated in the digestive gland. A biotransformation pathway of 8:2 diPAP in M. galloprovincialis was proposed on the basis of the results obtained in the present study and previous studies. These findings improve our understanding of the accumulation of perfluorocarboxylic acids in bivalve mollusks.

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FluoroMatch 2.0—making automated and comprehensive non-targeted PFAS annotation a reality

et al. 2021

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Because of the pervasiveness, persistence, and toxicity of per-and polyfluoroalkyl substances (PFAS), there is growing concern over PFAS contamination, exposures, and health effects. The diversity of potential PFAS is astounding, with nearly 10,000 PFAS catalogued in databases to date (and growing). The ability to detect the thousands of known PFAS, and discover previously uncatalogued PFAS, is necessary to understand the scope of PFAS contamination and to identify appropriate remediation and regulatory solutions. Current non-targeted methods for PFAS analysis require manual curation and are time-consuming, prone to error, and not comprehensive. FluoroMatch Flow 2.0 is the first software to cover all steps of data processing for PFAS discovery in liquid chromatography-high-resolution tandem mass spectrometry samples. These steps include feature detection, feature blank filtering, exact mass matching to catalogued PFAS, mass defect filtering, homologous series detection, retention time pattern analysis, class-based MS/MS screening, fragment screening, and predicted MS/MS from SMILES structures. In addition, a comprehensive confidence level criterion is implemented to help users understand annotation certainty and integrate various layers of evidence to reduce overreporting. Applying the software to aqueous film forming foam analysis, we discovered over one thousand likely PFAS including previously unreported species. Furthermore, we were able to filter out 96% of features which were likely not PFAS. FluoroMatch Flow 2 increased coverage of likely PFAS by over tenfold compared to the previous release. This software will enable researchers to better characterize PFAS in the environment and in biological systems.

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Bioaccumulation of perfluoroalkyl substances in marine echinoderms: Results of laboratory-scale experiments with Holothuria tubulosa Gmelin, 1791

Cited by 33 publications

References 79 publications

Effect of Perfluorooctanoic Acid on the Epigenetic and Tight Junction Genes of the Mouse Intestine

Effect of Perfluorooctanoic Acid on the Epigenetic and Tight Junction Genes of the Mouse Intestine

Uptake, Tissue Distribution, and Elimination of 8:2 Polyfluoroalkyl Phosphate Diesters in Mytilus galloprovincialis

FluoroMatch 2.0—making automated and comprehensive non-targeted PFAS annotation a reality

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