Bioaccumulation of PCB Congeners by Diporeia spp.: Kinetics and Factors Affecting Bioavailability

Landrum, Peter F.; Tigue, Elizabeth A.; Driscoll, Susan Kane; Gossiaux, Duane C.; Hoof, Patricia L. Van; Gedeon, Michelle L.; Adler, Matthew Clark

doi:10.1016/s0380-1330(01)70627-2

Cited by 24 publications

(23 citation statements)

References 17 publications

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“…2). An analogous inverse dependence of bioaccumulation on gammarid size was observed for PCBs and DDTs and was explained in terms of faster uptake kinetics and higher feeding rates of smaller specimens, as well as their selective feeding on smaller and more contaminated detrital particles (Landrum et al 2001;Viganò et al 2007). The biota to sediment accumulation factors (BSAF) showed deviations from simple partitioning and also evident changes along the River Po.…”

Section: Resultssupporting

confidence: 53%

Polybrominated Diphenyl Ethers (PBDEs) in Gammarids, Caddisflies, and Bed Sediments of the Lowland River Po

Viganò

Roscioli

Erratico

et al. 2008

Bull Environ Contam Toxicol

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Polybrominated diphenyl ethers (PBDEs) were investigated in sediments and invertebrates (gammarids and caddisflies) collected in the River Po, upstream and downstream from a polluted tributary. Besides a diffuse contamination by penta-BDE technical mixture, the river sediments identified the tributary as an important source to the main river of decabromodiphenyl ether (BDE-209), which peaked to 64 microg/g (OC) in the downstream stretch. At 10 km downstream from the tributary, a higher bioavailability was evident than at 22 km, and small gammarids accumulated at two/three times the levels of PBDEs found in large gammarids. The congener profiles of sediments and invertebrates were dominated by BDE-47, BDE-99 and BDE-209.

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Section: Resultssupporting

confidence: 53%

Polybrominated Diphenyl Ethers (PBDEs) in Gammarids, Caddisflies, and Bed Sediments of the Lowland River Po

Viganò

Roscioli

Erratico

et al. 2008

Bull Environ Contam Toxicol

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“…However, the uptake and values in the second 4‐d study were elevated by approximately a factor of two over the rate constants derived from the other test exposures. While elevated concentrations might have occurred if the animals were smaller, which leads to more rapid uptake as observed for PCB congeners in Diporeia [25], there was no observed difference in organism weight among the experiments. Despite the scatter in both the uptake and elimination coefficients, the elimination rate constant did track directly with the estimated uptake coefficient, which leads to a relatively constant estimate for the bioconcentration factor (BCF).…”

Section: Resultsmentioning

confidence: 99%

Time‐dependent toxicity of dichlorodiphenyldichloroethylene to Hyalella azteca

Landrum

Steevens

Chen

et al. 2005

Enviro Toxic and Chemistry

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Temporal effects on body residues of dichlorodiphenyldichloroethylene (DDE) associated with mortality in the freshwater amphipod Hyalella azteca were evaluated. Toxicokinetics and body residues were determined from water-only exposures that varied from 4 to 28 d, and DDE concentrations ranging from 0.0013 to 0.045 micromol L(-1). Uptake and elimination parameters were not affected significantly by the various temporal and concentration treatments. Uptake rate coefficients ranged from 134.3 to 586.7 ml g(-1) h(-1), and elimination rate coefficients ranged from 0.0011 to 0.0249 h(-1). Toxicity metric values included body residue for 50% mortality at a fixed sample time (LR50) and mean lethal residue to produce 50% mortality from individual exposure concentrations (MLR50) for live organisms and dead organisms. A twofold increase occurred in the MLR50 values calculated using live organisms compared to MLR50 values using dead organisms. Toxicity and kinetic data were fit to a damage assessment model that allows for the time course for toxicokinetics and damage repair, demonstrating the time-dependence of body residues to toxicity. The DDE appeared to act through a nonpolar narcosis mode of action for both acute and chronic mortality in H. azteca. Furthermore, the temporal trend in the toxic response using body residue as the dose metric is steep and found to be similar to another chlorinated hydrocarbon, pentachlorobenzene, but was more potent than that found for polycyclic aromatic hydrocarbons (PAHs).

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“…After arrival to the laboratory, organisms were allowed to acclimate for 48 h at 4ЊC before the start of the experiment. On the basis of reports describing the total body burdens of PCBs in Diporeia (Wong et al 2004) and a biota sediment accumulation factor of 1 (Landrum et al , 2001Kukkonen et al 2004), we exposed Diporeia to a mixture of eight PCB congeners (2-chlorobiphenyl, 2.3-dichlorobiphenyl, 2.4.5-trichlorobiphenyl, 2.2 .4.4 -tetrachlorobipheyl, 2.2 .3 .4.6.-pentachlorobiphenyl, 2.2 .4.4 .5.6 -hexachlorobiphenyl, 2.2 .3.3 .4.4 .6-heptachlorobiphenyl, and 2.2 .3.3 .4.5 .6.6 -octachlorobiphenyl) purchased from ChemService (West Chester, PA). The sediment for this experiment was collected from Lake Michigan and sterilized by autoclaving it.…”

Section: Pcb Exposurementioning

confidence: 99%

“…PCBs are known to elicit a myriad of toxic effects ranging from immunosuppression to cancer (Silkworth and Antrim 1985;Aznar et al 2005). Lipidrich Diporeia would be an ideal target for lipophilic-PCB mediated toxicity, which could potentially increase the susceptibility of Diporeia to secondary stressors (e.g., pathogens; Landrum et al , 2001. Furthermore, Diporeia are not only likely to be exposed to lipophilic contaminants but also highly sensitive to their effects (Gossiaux et al 1993;Landrum and Nalepa 1998;Ralston-Hooper et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Elucidating Causes ofDiporeiaDecline in the Great Lakes via Metabolomics: Physiological Responses after Exposure to Different Stressors

Maity¹,

Jannasch²,

Adamec³

et al. 2013

Physiological and Biochemical Zoology

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The benthic macroinvertebrate Diporeia spp. have been extirpated from many areas of the Laurentian Great Lakes, but the mechanisms underlying such declines are not fully understood. Diporeia declines coinciding with the invasion of exotic dreissenid mussels (zebra and quagga) have led to the hypothesis that Diporeia declines are a result of decreased food availability from increasing competition with dreissenids for diatoms. There is additional evidence that Diporeia are negatively affected when in close proximity to dreissenids, probably because of exposure to toxins present in the mussels' pseudofeces. Diporeia are also known to be sensitive to anthropogenic contaminants (such as polychlorinated biphenyls [PCBs]) present in Great Lakes sediments. To better understand the physiological responses of Diporeia to diverse stressors, we conducted three 28-d experiments evaluating changes in the metabolomes of Diporeia (1) fed diatoms (Cyclotella meneghiniana) versus starved, (2) exposed (from Lake Michigan and Cayuga Lake) to quagga mussels (Dreissena bugensis), and (3) exposed to sediments contaminated with PCBs. The metabolomes of samples were examined using both two-dimensional gas and liquid chromatography coupled with mass spectrometry. Each stressor elicited a unique metabolome response characterized by enhanced citric acid cycle, fatty acid biosynthesis, and protein metabolism in diatom-fed Diporeia; impaired glycolysis, protein catabolism, and folate metabolism in Diporeia from Lake Michigan irrespective of quagga mussel exposure, suggesting lake-specific adaptation mechanisms; and altered cysteine and phospholipid metabolism during PCB exposure. Subsequent comparisons of these stressor-specific metabolic responses with metabolomes of a feral Diporeia population would help identify stressors affecting Diporeia populations throughout the Great Lakes.

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Bioaccumulation of PCB Congeners by Diporeia spp.: Kinetics and Factors Affecting Bioavailability

Cited by 24 publications

References 17 publications

Polybrominated Diphenyl Ethers (PBDEs) in Gammarids, Caddisflies, and Bed Sediments of the Lowland River Po

Polybrominated Diphenyl Ethers (PBDEs) in Gammarids, Caddisflies, and Bed Sediments of the Lowland River Po

Time‐dependent toxicity of dichlorodiphenyldichloroethylene to Hyalella azteca

Elucidating Causes ofDiporeiaDecline in the Great Lakes via Metabolomics: Physiological Responses after Exposure to Different Stressors

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