Bioaccumulation of metals in human blood in industrially contaminated area

Jan, F. Akbar; Ishaq, Muhammad; Khan, Shehzad; Shakirullah, Mohammad; Asim, Syed Muhammad; Ahmad, Imtiaz; Mabood, Fazal

doi:10.1016/s1001-0742(10)60616-x

Cited by 27 publications

(16 citation statements)

References 16 publications

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“…S1, Supplementary material). Moreover, heavy metal bioaccumulation in the blood samples were found in the decreasing order of Cr4Zn 4Mn 4Ni 4Pb 4 Cu 4Cd which was detected multi-fold higher than those reported by Jan et al (2011) in Peshawar and Lower Dir in Pakistan, indicating large intake of metals through contaminated foods consumption, which clearly specifies the contribution of the selected food crops, milk and water on the metal composition of the human blood. The mean bioaccumulations of Cd in the adults blood were 0.0177 0.004, 0.017 70.003, 0.0167 0.003, 0.015 70.004 and 0.019 70.003 mg/L, while in the children blood they were 0.016 7 0.004, 0.015 70.004, 0.015 70.004, 0.0157 0.004 and 0.017 7 0.003 mg/L, in the five locations, namely Madyan, Fatehpur, Khwazakhela, Charbagh and Mingora, respectively ( Table 2).…”

Section: Bioaccumulation Of Heavy Metals In Human Bloodmentioning

confidence: 63%

“…After cooling the required samples were digested in 10 ml of HNO 3 and 5 ml of HClO 4 until a transparent solution was obtained. Moreover, the blood samples were extracted using Jan et al (2011) method. Briefly, 3 ml of blood sample was put into a conical flask and then 15 ml of HClO 4 and HNO 3 in the ratio of 1:4 were added.…”

Section: Extraction/digestionmentioning

confidence: 99%

“…The high concentration of Pb in the cattle's milk could be attributed to direct ingestion of fodder particularly water containing high levels of Pb in the area. Moreover, buffalo milk was found to have high concentrations of metals as compared to cow's milk which may be attributed to high fat content in buffalo's milk, which helps in metal retention due to the formation of bioactive (lipophilic) complexes (Jan et al, 2011). Zn concentrations in foodstuffs were also shown variation across the region; however, its highest mean concentration (0.235 mg/kg) was noticed in pulses; while the lowest (0.022 mg/kg) in water (Fig.…”

Section: Levels Of Heavy Metals In Foodstuffsmentioning

confidence: 99%

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Evaluation of toxicological risk of foodstuffs contaminated with heavy metals in Swat, Pakistan

Khan

Lü

et al. 2014

Ecotoxicology and Environmental Safety

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a b s t r a c tThis study aimed to assess the concentrations of heavy metals such as cadmium (Cd), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb) and zinc (Zn) in the available foodstuffs (crops, milk and water), their bioaccumulation in human body and potential human health risks in Swat valley, northern Pakistan. Heavy metal concentrations in foodstuffs and human blood (adults (18-above) and children (1-12 years)) were analyzed using atomic absorption spectrometer. The results revealed high level of Mn in foodstuffs followed by Cr 4Cu 4Zn4Ni 4 Cd 4Pb, which significantly increased the levels of heavy metals in the adult's blood as compared to that of children in the order of Cr 4 Zn4Mn4 Ni 4Pb 4Cu 4Cd. Principal component analysis showed that selected foodstuffs were the possible sources of metal contamination in human blood, while correlation analysis revealed that the concentrations of Cr, Cu, Mn, Ni, Pb and Zn in foodstuffs significantly correlated with that in human blood. Moreover, risk assessments for individual metals via foodstuffs were found within safe limits, except for Cd (HQ 4 1); Whereas, for aggregate multiple metals the risk was calculated as 3.97E þ00 (HI 41), in which water and milk were perceived as the greater contributors (81 percent) to HI; while fruits, grains and vegetables contributed 5 percent each, and pulses 4 percent.

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Section: Bioaccumulation Of Heavy Metals In Human Bloodmentioning

confidence: 63%

Section: Extraction/digestionmentioning

confidence: 99%

Section: Levels Of Heavy Metals In Foodstuffsmentioning

confidence: 99%

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Evaluation of toxicological risk of foodstuffs contaminated with heavy metals in Swat, Pakistan

Khan

Lü

et al. 2014

Ecotoxicology and Environmental Safety

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“…The residual concentrations of heavy metals in cow blood could be an important "direct indicator" of the safety status of cow meat consumed, as well as an "indirect indicator" of the degree of pollution of the environment in which the cow was breed. One of the main problems with metals is their ability to bio-accumulate in plant (Bhatti et al, 2016) and animals (Akbar- Jan et al, 2011;Chowdhury et al, 2011;Lotfy et al, 2013;Abd El-Salam et al, 2013;Li et al, 2015;Ogamba et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Hematotoxicity status of lead and three other heavy metals in cow slaughtered for human consumption in Jos, Nigeria

Nwidu¹,

Ohemu²

2017

J. Toxicol. Environ. Health Sci.

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“…Heavy metals were analyzed by Jan et al (2011) in different food crops, milk and meat, and blood samples collected from different age group subjects such as children (1-12 years), adolescent (12-18 years), adults (18-45 years) and old age (above 45 and 55 years for males and females, respectively) from polluted and relatively less polluted areas. The results revealed that consumption of contaminated food crops, meat and milk have significantly increased concentrations of selected metals in the human blood.…”

Section: Introductionmentioning

confidence: 99%

Remediation of heavy metal contaminated ecosystem: an overview on technology advancement

Singh

Prasad

2014

Int. J. Environ. Sci. Technol.

132

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The issue of heavy metal pollution is very much concerned because of their toxicity for plant, animal and human beings and their lack of biodegradability. Excess concentrations of heavy metals have adverse effects on plant metabolic activities hence affect the food production, quantitatively and qualitatively. Heavy metal when reaches human tissues through various absorption pathways such as direct ingestion, dermal contact, diet through the soil-food chain, inhalation and oral intake may seriously affect their health. Therefore, several management practices are being applied to minimize metal toxicity by attenuating the availability of metal to the plants. Some of the traditional methods are either extremely costly or they are simply applied to isolate contaminated site. The biology-based technology like use of hypermetal accumulator plants occurring naturally or created by transgenic technology, in recent years draws great attention to remediate heavy metal contamination. Recently, applications of nanoparticle for metal remediation are also attracting great research interest due to their exceptional adsorption and mechanical properties and unique electrical property, highly chemical stability, and large specific surface area. Thus, the present review deals with different management approaches to reduce level of metal contamination in soil and finally to the food chain.

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Bioaccumulation of metals in human blood in industrially contaminated area

Cited by 27 publications

References 16 publications

Evaluation of toxicological risk of foodstuffs contaminated with heavy metals in Swat, Pakistan

Evaluation of toxicological risk of foodstuffs contaminated with heavy metals in Swat, Pakistan

Hematotoxicity status of lead and three other heavy metals in cow slaughtered for human consumption in Jos, Nigeria

Remediation of heavy metal contaminated ecosystem: an overview on technology advancement

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