Bioaccumulation of heavy metals in different components of two Lake Ecosystem

Tirkey, Amiya; Shrivastava, Priyanka; Saxena, A.

doi:10.12944/cwe.7.2.15

Cited by 20 publications

(11 citation statements)

References 2 publications

(1 reference statement)

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“…17 Amara et al showed that due to cadmium exposure the antioxidant enzyme activity reduced in rat hippocampus and cortex. 18 The mechanism of toxic and neurotoxic effects of cadmium could be due to oxidative stress, 19 free radicals generation, mitochondria membrane depolarization 20 and of reactive oxygen species (ROS) generation, 9 altering genes expression and eventually inducing apoptosis. 21 ROS is a regulator of cell death.…”

Section: Introductionmentioning

confidence: 99%

Effects of cadmium on Bcl-2/Bax expression ratio in rat cortex brain and hippocampus

2017

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To investigate the underlying mechanism of neurotoxicity of cadmium, we examined the effects of intraperitoneal injection of cadmium on messenger RNA (mRNA) expression of Bcl-2 (B-cell lymphoma 2) and Bax (Bcl2-associated x) genes and caspase-3/7 activation in rat hippocampus and frontal cortex. Twenty-eight male Wistar rats weighing 200-250 g were randomly divided into four groups. Control group received saline and three other groups received cadmium at doses of 1, 2 and 4 mg/kg (body weight) for 15 successive days. One day after the last injection, the hippocampus and frontal cortex were dissected and removed and then the expression of Bcl-2 and Bax genes was evaluated using real-time polymerase chain reaction and apoptotic studies was done using caspase-3/7 activation assay. Cadmium reduced the mRNA level of Bcl-2 in the control group at doses of 1 ( p < 0.01), 2 and 4 mg/kg ( p < 0.001) in rat hippocampus and cortex cells. The mRNA level of Bax increased significantly compared to the control group at the doses of 1 ( p < 0.05), 2 and 4 mg/kg ( p < 0.001) in rat hippocampus. The mRNA level of Bax was increased significantly compared to the control group at the doses of 2 and 4 mg/kg ( p < 0.001) in rat cortex cells. Cadmium increased caspase-3/7 activity at doses of 1, 2 and 4 mg/kg in rat hippocampus. Caspase-3/7 activity was increased significantly at dose of 4 mg/kg in rat cortex. This decreased Bcl-2/Bax mRNA ratio induces cell apoptosis. Apoptotic effect of cadmium may be through the mitochondrial pathway by the activation of caspase-3/7.

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Section: Introductionmentioning

confidence: 99%

Effects of cadmium on Bcl-2/Bax expression ratio in rat cortex brain and hippocampus

2017

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“…are essential micronutrients for higher animals and plant growth but their high concentration may cause health problem 3,4 hence lot of work has been carried out to assess heavy metal bioaccumulation in different vegetables and plants 5,6,7,8,9,10,11,12 which show that heavy metals are non-biodegradable and persistent environmental contaminants which are deposited on the surfaces and then absorbed into the tissues of vegetables. Plants take up heavy metals by absorbing them from contaminated soil.…”

Section: Introductionmentioning

confidence: 99%

Bioaccumulation of Heavy Metal Toxicity in the Vegetables of Mahalgaon, Nagpur, Maharashtra (India)

Mahakalkar¹,

Gupta²,

Nandeshwar³

2013

Curr World Environ

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Mahalgaon is a village in Kamptee Taluka, Nagpur district of Maharashtra state, India. Most of the village formers from this village are engaged in vegetable cultivation and the village serves as one of the main supplier of vegetables required in the Nagpur market. All the fields and farms of this region are irrigated by the Nag river water which is highly polluted by urban waste and heavy metals. The purpose of this study was to study the bioaccumulation of heavy metals i.e. Cu, Mn, Fe, Zn, Ni and Pb in Water, Soil and Vegetables irrigated by Nag River water and to evaluate the level of bioaccumulation of the metals by the different vegetables. For this study five farms were selected in the Mahalgaon region. Each farm was situated near the bank of Nag River. The sampling was carried out according to grab method as given in APHA for the sampling of water, soil and vegetables. The concentration of heavy metals (Cu, Mn, Fe, Zn, Ni, Pb) were analyzed using Atomic Absorption Spectrophotometer (AAS). It was found that in water the concentration of Iron and zinc was highest whereas conc. of Nickel and lead was lowest. The concentration of Fe and Zn in the soil samples was very high compared to the WHO/FAO maximum permissive limits while the concentrations of Cu and Mn were slightly above the permissible limits. The concentration of Pb and Ni were below the detection limits in soil. On the other hand in all the vegetables, the concentration of heavy metals was higher than the WHO/FAO permissible limits. the soil-plant transfer factor of different heavy metals shows the following order-TFZn> TF Fe >TF Cu >TF Ni >TF Mn >TF Pb .

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“…With the increase of these parameters, the concentration of ions of Cu(II) decreases in addition to the Cu toxicity to aquatic systems. High doses may also cause anaemia, liver and kidney damage, stomach and intestinal irritation [Tirkey et al, 2012]. Copper ions (Cu 2+ ) are toxic to most life forms.…”

Section: +mentioning

confidence: 99%