Bioaccumulation of decabromodiphenyl ether (BDE209) in earthworms in the presence of lead (Pb)

Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae

“…A recent study reported that exposure of higher levels of Pb to earthworms showed less bioaccumulation of BDE-209 (Zhang et al, 2014). In addition, we observed that co-exposure to Pb alters the profiles of BDE-209 metabolites in zebrafish larvae; these observations are consistent with our recent study (Zhu et al, 2014).…”

Transgenerational endocrine disruption and neurotoxicity in zebrafish larvae after parental exposure to binary mixtures of decabromodiphenyl ether (BDE-209) and lead

“…This contrasting changing trend of BDE-197 and the other congeners indicated that transfer of Pb to 5 dpf larvae accelerated the successive and selective removal of bromine atoms at the meta position from BDE-209 and -207 to BDE-197, but blocked the advanced debromination of BDE-197 to lower brominated congeners (e.g., BDE-100 and -47), which caused the increased accumulation of . Although previous studies demonstrated that acute exposure to Pb inhibited the uptake of BDE-209 in zebrafish larvae (Chen et al, 2016a;Zhu et al, 2014Zhu et al, , 2016 and earthworms Zhang et al, 2014), the observed blockage of bromination towards BDE-47 is consistent with current results. Interestingly, in contrast to the eggs, the concentrations of Pb in the larvae were gradually decreased with increasing concentrations of BDE-209 in the coexposure groups (M1, M10 and M100) and a significant difference was observed between the M10 group and the Pb group (Fig.…”

“…Previous studies have shown that high levels of Pb can inhibit the uptake and debromination kinetics of BDE-209 in earthworms Zhang et al, 2014) and zebrafish larvae (Chen et al, 2016a;Zhu et al, 2014Zhu et al, , 2016. Toxicological actions are also altered under coexposure scenarios via synergistic, inhibitory, or additive interactions.…”

Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae

“…In this regard, Pb may inhibit enzyme activity as studies have reported that Pb can replace Se in the deiodination reaction (Lopez et al, 2000), because deiodinase is a Se-containing enzyme with selenocysteine that comprises the active site of deiodinase (St Germain and Galton, 1997). A recent study also reported that the ability to degrade BDE-209 becomes weaker due to an exposure to a high concentration of Pb, resulting in lowered production of BDE-206 and BDE-208 in earthworms (Zhang et al, 2014).…”

“…These results suggested enhanced bioavailability of metals in the presence of trace levels of organic compounds and that a higher concentration of Pb could inhibit BDE-209 uptake. A recent study in earthworms exposed to higher levels of Pb showed less bioaccumulation of BDE-209 (Zhang et al, 2014). The authors speculated that a greater supply of Pb can destroy skin structure and adversely impact BDE-209 uptake through the skin.…”