Bioaccumulation, elimination and metabolism in earthworms and microbial indices responses after exposure to decabromodiphenyl ethane in a soil-earthworm-microbe system

Jiang, Lingling; Ling, Siyuan; Fu, Mengru; Peng, Cheng; Zhang, Wei; Lin, Kuangfei; Zhou, Bingsheng

doi:10.1016/j.envpol.2021.117965

Cited by 25 publications

(6 citation statements)

References 57 publications

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“…Previous studies revealed seven metabolites of DBDPE in rats (Wang et al, 2010) and zebrafish (Wang X. et al, 2019). Jiang et al (2021) reported three nona-BDPE, four nonabrominated, three octa-BDPE, and four hepta-BDPE products in earthworms, similar to our results. However, the proportions of different metabolite types varied between the group exposed to 10 μg/L DBDPE and the group co-exposed to 10 μg/L DBDPE + n-TiO 2 , indicating a possibility that the presence of n-TiO 2 could affect the metabolism of DBDPE.…”

Section: N-tio 2 Affected the Bioaccumulation And Biotransformation O...supporting

confidence: 91%

Nano-TiO2 Adsorbed Decabromodiphenyl Ethane and Changed Its Bioavailability, Biotransformation and Biotoxicity in Zebrafish Embryos/Larvae

Wang

Sun

et al. 2022

Front. Environ. Sci.

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Decabromodiphenyl ethane (DBDPE), a novel brominated flame retardant, may co-exist with other pollutants including nanoparticles (NPs) in aquatic environment. Due to structural similarity with decabromodiphenyl ether, DBDPE has been reported to exhibit thyroid disrupting effects and neurotoxicity. This study further evaluated the behavior of DBDPE in aqueous environments along with the bioavailability and toxicity of DBDPE in aquatic organisms in the presence of TiO2 nanoparticles (n-TiO2). When co-existing in an aqueous environment, DBDPE was adsorbed by n-TiO2, potentially facilitating the sedimentation of DBDPE from the aqueous phase. Co-exposure to DBDPE and n-TiO2 significantly increased the uptake of DBDPE by zebrafish (Danio rerio) embryos and altered the composition of metabolites in zebrafish larvae compared to zebrafish exposed to DBDPE alone. The DBDPE-induced increases in heart rate, tail bending frequency, average speed under dark/light stimulation, and thyroid hormone levels in zebrafish embryos/larvae were further enhanced in the presence of n-TiO2. Overall, the results demonstrate that n-TiO2 affected the behavior of DBDPE in the aqueous phase and increased the bioavailability and biotoxicity of DBDPE in zebrafish embryos/larvae. These results could be helpful for understanding the environmental behavior and toxicity of DBDPE.

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Section: N-tio 2 Affected the Bioaccumulation And Biotransformation O...supporting

confidence: 91%

Nano-TiO2 Adsorbed Decabromodiphenyl Ethane and Changed Its Bioavailability, Biotransformation and Biotoxicity in Zebrafish Embryos/Larvae

Wang

Sun

et al. 2022

Front. Environ. Sci.

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“…As a model organism to study potential toxicological risks of environmental pollutants, earthworms are sensitive and prefer to metabolize pollutants by activating detoxification mechanisms . CPY450, CarE, and GST are the main detoxification enzymes that catalyze pollutant metabolism in earthworms . In this study, changes in CYP450, CarE, and GST activities were determined in earthworms after S -FEN and R -FEN exposure.…”

Section: Results and Discussionmentioning

confidence: 97%

“…13 CPY450, CarE, and GST are the main detoxification enzymes that catalyze pollutant metabolism in earthworms. 43 In this study, changes in CYP450, CarE, and GST activities were determined in earthworms after S-FEN and R-FEN exposure. CYP450 is a family of membranebound hemoproteins that play a pivotal role in metabolizing xenobiotics in organisms.…”

Section: Enantioselective Effects On Detoxification Enzyme Activitymentioning

confidence: 99%

Enantiomer-Specific Study of Fenpropathrin in Soil-Earthworm Microcosms: Enantioselective Bioactivity, Bioaccumulation, and Toxicity

Zhang

Yang

Shi

et al. 2022

J. Agric. Food Chem.

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In this study, the enantiomer-specific bioactivity, bioaccumulation, and toxicity of fenpropathrin (FEN) enantiomers were investigated in soil-earthworm microcosms. The bioactivity order was S-FEN > rac-FEN > R-FEN for Spodoptera litura and Conogethes punctiferalis. Moreover, S-FEN was 12.0 and 32.2 times more toxic than rac-FEN and R-FEN to earthworms, respectively. S-FEN degraded faster than R-FEN with the enrichment of R-FEN in the soil environment. Furthermore, the peak-shaped accumulation curves for FEN enantiomers were observed, and R-FEN was preferentially bioaccumulated by earthworms. As compared to R-FEN, S-FEN induced greater changes in the activities of detoxification enzymes, antioxidant enzymes, and malondialdehyde content, which suggested that earthworms exhibited enantioselective defense responses to S-FEN and R-FEN. Integrated biomarker response results indicated that S-FEN exhibited higher toxic effects on earthworms than R-FEN. Finally, molecular simulation revealed that the greater interaction forces between S-FEN and sodium channel protein could be the primary reason for the enantioselective bioactivity and toxicity of FEN enantiomers. This study comprehensively highlights the enantiomer-specific bioactivity, bioaccumulation, toxicity, and mechanism of FEN in soil-earthworm microcosms at the enantiomer level. Our findings will contribute to a better risk assessment of FEN in the soil ecosystem.

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“…32,33 Meanwhile, earthworms exposed to 5−100 mg kg −1 DBDPE suffered from tissue damage and apoptosis. 34,35 However, the bioaccumulation interplay and combined toxicity of MPs and DBDPE remain unclear. This study hypothesized that ABS-MPs affect the DBDPE bioaccumulation by earthworms, and both the adsorption of DBDPE on ABS-MPs and the adverse effects of ABS-MPs on the physiological status of earthworms involve the mechanisms.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Earthworm ( Eisinia fetida ) is a model organism for the ecotoxicological risks assessments in the terrestrial system. , Previous studies indicated that MPs, such as polyester, polyethylene terephthalate, polyethylene, and polystyrene, had adverse effects on earthworm egestion rate, growth, and oxidative response, especially MPs with concentrations higher than 0.5% (w/w) and sizes smaller than 0.1 μm. , Meanwhile, earthworms exposed to 5–100 mg kg –1 DBDPE suffered from tissue damage and apoptosis. , However, the bioaccumulation interplay and combined toxicity of MPs and DBDPE remain unclear. This study hypothesized that ABS-MPs affect the DBDPE bioaccumulation by earthworms, and both the adsorption of DBDPE on ABS-MPs and the adverse effects of ABS-MPs on the physiological status of earthworms involve the mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Insight into Bioaccumulation of Decabromodiphenyl Ethane in Eisenia fetida Increased by Microplastics

Fu,

Tan,

Zhou

et al. 2023

Environ. Sci. Technol.

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The rise of electronics inevitably induced the co-pollution of novel brominated flame retardants (NBFRs) and microplastics (MPs). However, studies on how they interact to influence their bioavailability are scarce. Here, we explored the influence mechanism of acrylonitrile butadiene styrene (ABS)-MPs on the bioaccumulation of decabromodiphenyl ethane (DBDPE) in soil-earthworm microcosms. The influence exhibited a temporal pattern characterized by short-term inhibition and long-term promotion. After 28 days of exposure, DBDPE bioaccumulation in a co-exposure (10 mg kg–1 DBDPE accompanied by 1000 mg kg–1 ABS-MPs) was 2.61 times higher than that in a separate exposure. The adsorption process in the soil, intestines, and mucus introduced DBDPE-carried MPs, which had a higher concentration of DBDPE than the surrounding soil and directly affected the bioavailability of DBDPE. MP-pre-exposure (100, 1000, and 10000 mg kg–1) reduced epidermal soundness, mucus secretion, and worm cast production. This eventually promoted the contact between earthworm and soil particles and enhanced the DBDPE of earthworm tissue by 6%–61% in the next DBDPE-postexposure period, confirming that MPs increased DBDPE bioaccumulation indirectly by impairing the earthworm health. This study indicates that MPs promoted DBDPE bioaccumulation via adsorption and self-toxicity, providing new insight into the combined risk of MPs and NBFRs.

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Bioaccumulation, elimination and metabolism in earthworms and microbial indices responses after exposure to decabromodiphenyl ethane in a soil-earthworm-microbe system

Cited by 25 publications

References 57 publications

Nano-TiO2 Adsorbed Decabromodiphenyl Ethane and Changed Its Bioavailability, Biotransformation and Biotoxicity in Zebrafish Embryos/Larvae

Nano-TiO2 Adsorbed Decabromodiphenyl Ethane and Changed Its Bioavailability, Biotransformation and Biotoxicity in Zebrafish Embryos/Larvae

Enantiomer-Specific Study of Fenpropathrin in Soil-Earthworm Microcosms: Enantioselective Bioactivity, Bioaccumulation, and Toxicity

Insight into Bioaccumulation of Decabromodiphenyl Ethane in Eisenia fetida Increased by Microplastics

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