Bioaccumulation and toxicity of polystyrene nanoplastics on marine and terrestrial organisms with possible remediation strategies: A review

Gupta, Charu; Kaushik, Sarthak; Himanshu, -; Jain, Shruti; Dhanwani, Ishika; Mansi,; Garg, Sonali; Paul, Ankush; Pant, Parul; Gupta, Nikesh

doi:10.1016/j.envadv.2022.100227

Cited by 23 publications

(6 citation statements)

References 109 publications

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“…In contrast to digestive or respiratory organs, the ovary is separated by the body cavity and is unlikely to remain in direct contact with the nanoplastics, suggesting an intrinsic uptake route for nanoplastic into the ovary. Previously, it has been shown that nanoparticles with a hydrodynamic size of less than 200 nm are capable of membrane penetration, although this can be influenced by shape and/or surface functional groups of the nanoparticles, , as verified in various organisms at the cellular and individual levels. , Indeed, size-selective bioaccumulation of nanoparticles (<100 nm) in the reproductive organs of the mouse is reportedly associated with increased blood-vessel density during ovulation due to the blood-vessel membrane permeability of nanoplastics . Moreover, the fact that lipids constitute a major proportion of fish egg yolk (in the form of lipid droplets) supports the bioaccumulation of hydrophobic nanoplastics. − Given that Oryzias spp.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the fact that lipids constitute a major proportion of fish egg yolk (in the form of lipid droplets) supports the bioaccumulation of hydrophobic nanoplastics. − Given that Oryzias spp. has a daily ovulation cycle, and considering the high blood-vessel density during ovulation, a synergistic uptake mechanism may be responsible for the strong nanoplastic bioaccumulation in medaka ovaries. In addition, it is arguable that a change in δ 13 C values would be a consequence of alterations in metabolite compositions rather than nanoplastic bioaccumulation.…”

Section: Resultsmentioning

confidence: 99%

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Insights into Tissue-Specific Bioaccumulation of Nanoplastics in Marine Medaka as Revealed by a Stable Carbon Isotopic Approach

Yeo,

Shim,

Kim

et al. 2023

Environ. Sci. Technol. Lett.

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Despite the high bioavailability and potentially extensive presence of nanoplastics in aquatic environments, the biological fate of nanoplastics is largely unknown because of analytical limitations in detection and quantification. Fluorescently labeled nanoplastics are widely used to detect bioaccumulation, but this method is prone to false-positive results due to the leaching of fluorescent dyes. Here we propose a novel stable carbon isotopic approach to detect and quantify nano- and microplastics in a complex organic matrix. Because carbon is the major component of plastics (>87% in polystyrene), it is possible to investigate tissue-specific bioaccumulation of nano- and microplastics in the medaka Oryzias melastigma by quantifying the contribution of plastic particles as an end-member in the composition of stable carbon isotopes in different tissues. In addition to the digestive organs (e.g., the gut and intestines) that are constantly exposed to the water column via ingestion, nanoplastics were shown to selectively bioaccumulate in the gills and ovary, implying a unique mode of action of bioaccumulation based on the physicochemical properties of the nanoparticles. These findings should improve our understanding of the tissue-specific bioaccumulation of nano- and microplastics in aquatic organisms.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Insights into Tissue-Specific Bioaccumulation of Nanoplastics in Marine Medaka as Revealed by a Stable Carbon Isotopic Approach

Yeo,

Shim,

Kim

et al. 2023

Environ. Sci. Technol. Lett.

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“…3 Polystyrene nanoplastics (PSNPs) are a significant representative of nanoplastics that get degraded from widely used disposable plates, tea cups, and so forth and have been extensively studied for their toxicity to all species. 4 Scientific studies have proved that polystyrene nanoplastics (PSNPs) adsorb a wide range of environmental contaminants such as pharmaceuticals (oxytetracycline 5 and ciprofloxacin 6 ), pesticides (fipronil, 7 triadimenol (TRI), myclobutanil (MYC), and hexaconazole (HEX)), 8 POPs (polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and dichlorodiphenyltrichloroethane (DDT) 9 ), and heavy metals (arsenic 10 ). However, the adsorption of these substances depends on various factors such as the characteristics of the plastics (particle size, surface area/volume, surface charge, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, by adsorbing various copollutants on their surfaces, such as heavy metals, organic pollutants, and medicinal chemicals, nanoplastics serve as vectors for the transportation of other copollutants . Polystyrene nanoplastics (PSNPs) are a significant representative of nanoplastics that get degraded from widely used disposable plates, tea cups, and so forth and have been extensively studied for their toxicity to all species . Scientific studies have proved that polystyrene nanoplastics (PSNPs) adsorb a wide range of environmental contaminants such as pharmaceuticals (oxytetracycline and ciprofloxacin), pesticides (fipronil, triadimenol (TRI), myclobutanil (MYC), and hexaconazole (HEX)), POPs (polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and dichlorodiphenyltrichloroethane (DDT)), and heavy metals (arsenic).…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Modification of Esterase-like Activity of Serum Albumin by Nanoplastics and Their Cocontaminants

Rajendran,

Chandrasekaran

2023

ACS Omega

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Nanoplastics and other cocontaminants have raised concerns due to their widespread presence in the environment and their potential to enter the food chain. The harmful effects of these particles depend on various factors, such as nanoparticle size, shape, surface charge, and the nature of the cocontaminants involved. On entering the human body, human serum albumin (HSA) molecules bind and transport these particles in the blood system. The esterase-like activity of HSA, which plays a role in metabolizing drug/toxic compounds, was taken as a representative to portray the effects of these particles on HSA. Polystyrene nanoplastics (PSNPs) with different surface functionalization (plain (PS), amine (PS-NH 2 ), and carboxy (PS-COOH)), different sizes (100 and 500 nm), and PS with cocontaminant metformin hydrochloride (Met-HCl), a widely used antidiabetic drug, were investigated in this study. Fluorescence emission spectra of HSA revealed that PS-NH 2 exhibits a greater effect on protein conformation, smaller NPs have a greater influence on protein structure than larger NPs, and Met-HCl lowers PSNPs' affinity for HSA by coating the surface of the NPs, which may result in direct NP distribution to the drug's target organs and toxicity. Circular dichroism spectra also supported these results in terms of secondary structural changes. Esterase activity of HSA was inhibited by all the particles (except Met-HCl) by competitive inhibition as concluded from constant V max and increasing K m . Greater reduction in enzyme activity was observed for PS-NH 2 among functionalizations and for 100 nm PS among sizes. Furthermore, Met-HCl lowers the inhibitory impact of PSNPs on HSA since the drug binds weakly to HSA, and so they can serve as a vector delivering PSNPs to their target organs, resulting in serious implications.

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“…Independent of their exact chemical composition, synthetic polymer fragments with dimensions smaller than 5 mm are collectively referred to as microplastics, , while even smaller plastic particles with dimensions between 1 and 1000 nm are referred to as nanoplastics . Although the impact of micro- to nanosized plastics on biota are still insufficiently understood, reports of decreased sperm motility, birth defects, intestinal membrane damage, organ toxicity, bioaccumulation, and even death in fish, − zebrafish, , crustaceans, mice, ,, and humans give reasons for concern. Studies investigating human health are limited, but hundreds of microsized plastic particles were detected in stool samples .…”

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confidence: 99%

Nanoplastics Weathering and Polycyclic Aromatic Hydrocarbon Mobilization

Schiferle

Reinhard

2023

ACS Nano

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Despite increasing efforts to recycle plastic materials, large quantities of plastics waste continue to accumulate in the oceans. Persistent mechanical and photochemical degradation of plastics in the oceans yields micro-and nanoscale plastic particles, which represent potential vectors for mobilizing hydrophobic carcinogens in an aqueous milieu. Yet, the fate and potential threats associated with plastics remain largely unexplored. Herein, we apply an accelerated weathering protocol to consumer plastics to characterize the effect of photochemical weathering on the size, morphology, and chemical composition of nanoplastics under defined conditions and validate that the photochemical degradation is consistent with plastics harvested from the Pacific Ocean. Machine learning algorithms trained with accelerated weathering data successfully classify weathered plastics from nature. We demonstrate that photodegradation of poly(ethylene terephthalate) (PET)-containing plastics produces enough CO 2 to induce a mineralization process that results in the deposition of CaCO 3 on nanoplastics. Finally, we determine that despite UV-radiation induced photochemical degradation and mineral deposition, nanoplastics retain their ability to sorb, mobilize, and increase bioaccessibility of polycyclic aromatic hydrocarbons (PAHs) in water and under simulated physiological gastric and intestinal conditions.

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Bioaccumulation and toxicity of polystyrene nanoplastics on marine and terrestrial organisms with possible remediation strategies: A review

Cited by 23 publications

References 109 publications

Insights into Tissue-Specific Bioaccumulation of Nanoplastics in Marine Medaka as Revealed by a Stable Carbon Isotopic Approach

Insights into Tissue-Specific Bioaccumulation of Nanoplastics in Marine Medaka as Revealed by a Stable Carbon Isotopic Approach

Unveiling the Modification of Esterase-like Activity of Serum Albumin by Nanoplastics and Their Cocontaminants

Nanoplastics Weathering and Polycyclic Aromatic Hydrocarbon Mobilization

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