Bioaccumulation and toxicity effects of flubendiamide in zebrafish (Danio rerio)

Abstract

As a diamide insecticide, ubendiamide is widely used and has many adverse effects on environmental organisms. In this study, bioaccumulation and toxicity effects of ubendiamide in zebra sh (Danio rerio) were studied. Speci cally, the results showed that the concentrations of ubendiamide increased in the early stage and achieved steady stages at 14 days and the bioconcentration factors (BCFs) of ubendiamide in zebra sh were 1.125 -2.011. Furthermore, ubendiamide had no signi cant effects on the growth phenotypes of zebra sh. However, zebra sh hepatic somatic index (HSI) of zebra sh had changed signi cantly with exposure. Histopathological analysis showed that exposure to ubendiamide could cause structural damage to liver tissue of zebra sh. Further physiological and biochemical analysis showed that ubendiamide could signi cantly change the activity of CAT and the contents of MDA and GSH in liver of zebra sh. In particular, exposure to ubendiamide could also cause signi cant changes in the mRNA expression levels of cell apoptosis-related genes involving p53, puma, caspase-3, caspase-9, apaf-1 and bax in liver of zebra sh. In general, these results indicated that exposure to ubendiamide could induce liver damage by inducing oxidative stress and apoptosis in liver of zebra sh.The results of this study will help to further comprehensively evaluate the safety of ubendiamide to aquatic organisms.

Evaluation of the Two Typical Diamide Insecticide-Induced Oxidative Damages and the Molecular Mechanism Underlying Their Toxicity in Triticum aestivum

“…As the first developed diamide insecticide, flubendiamide with broad spectrum and persistent inhibition effects has attracted much more attention on the development of the diamide insecticide industry . Although the usage of flubendiamide has been restricted on many crops due to the high toxicity to aquatic organisms and serious threat to the aquatic environment, it still has widespread applications in lepidopteran pest control at present, especially for larvae. − As the first and the most pervasive anthranilic diamide insecticide, chlorantraniliprole possesses strong permeability and powerful systemicity, especially for resistance to rain erosion. In addition, chlorantraniliprole displays high selectivity against target pests and low toxicity to mammals; therefore, it has also been widely used for lepidopteran management in agriculture and forestry to improve yield reductions. , In addition, chlorantraniliprole has been extensively used in rice planting due to its efficient protection against rice leaf folders and stem borers …”

Design, Synthesis, and Insecticidal Activities of Novel N‐Pyridylpyrazole Amide Derivatives Containing a Maleimide

“…[6] Due to its toxicity to aquatic organisms, it was later banned. [7] Unlike flubendiamide, chlorantraniliprole (CHL) was an anthranilic diamide insecticide developed by DuPont. [8,9] CHL has efficient larvicidal activities against lepidopteran pests such as Mythimna separata (M. separata), Plutella xylostella (P. xylostella), and Spodoptera frugiperda.…”

“…Flubendiamide, discovered and developed by Nihon Nohyaku and Bayer, was the first synthetic phthalic acid diamide insecticide [6] . Due to its toxicity to aquatic organisms, it was later banned [7] . Unlike flubendiamide, chlorantraniliprole ( CHL ) was an anthranilic diamide insecticide developed by DuPont [8,9] .…”