Bioaccumulation and toxic effects of nanoparticulate and ionic silver in Saccostrea glomerata (rock oyster)

Abstract

Do w nlo a d e d fro m: h t t p://i n si g h t. c u m b ri a. a c. u k/i d/ e p ri n t/ 4 1 4 8/ U s a g e o f a n y i t e m s f r o m t h e U n i v e r s i t y o f C u m b r i a' s i n s t i t u t i o n a l r e p o s i t o r y 'I n s i g h t' m u s t c o n f o r m t o t h e f o l l o w i n g f a i r u s a g e g u i d e l i n e s. Bioaccumulation and toxic effects of nanoparticulate and ionic silver in Saccostrea glomerata (rock oyster

Cytotoxicity of Metal‐Based Nanoparticles: From Mechanisms and Methods of Evaluation to Pathological Manifestations

“…Metalbased NPs can cause different levels of DNA damage. [140,141] Many approaches to evaluate DNA damage have been developed, including a comet assay, micronucleus assay, and terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) assay. The comet assay can accurately assess DNA repair function and detect teratogenic substances over time.…”

Building the Bridge From Aquatic Nanotoxicology to Safety by Design Silver Nanoparticles

“…A different tissue response towards 20–30 nm Cit-coated AgNPs and bulk Ag forms is reported for Crassostrea virginica with oxidative damage in the gills upon exposure to dissolved Ag and in the digestive glands to AgNPs with consequences on metabolism and reproductive impairments, suggesting a distinct NP effect ( McCarthy et al, 2013 ). More recently, Carrazco-Quevedo et al (2019 ) reported higher dissolution rate of low concentrations of AgNPs NM300K (20 ± 5 nm) (12.5 µgL −1 vs 125 µgL −1 ) in the presence of the rock oyster Saccostrea glomerata , with higher bioaccumulation in the gills, but not the digestive gland and induction of DNA strand breaks and oxidative stress biomarkers (GST, GR, and lipid peroxidation (LPO)). The authors underline the importance of characterizing the bio-nano-interaction of AgNPs in seawater media which are affecting dissolution and aggregation, thus influencing the uptake and bioaccumulation of AgNPs, including aggregates.…”

Comparative study of the sensitivity of two freshwater gastropods, Lymnaea stagnalis and Planorbarius corneus, to silver nanoparticles: bioaccumulation and toxicity

“…There is controversy over the toxic mechanism of AgNPs. As some studies indicated (Gao et al, 2021;Shen et al, 2015;Yan et al, 2021) that the Ag + was a major contributor to AgNP toxicity; however, other studies suggested that the toxicity of AgNPs was attributed to the particles (Bao et al, 2018;Carrazco-Quevedo et al, 2019). Some metal and metal oxide NPs, such as AuNPs and TiO 2 NPs, even if not capable of releasing ions, could also trigger toxic effects by inducing oxidative stress (Arini et al, 2020;Girardello et al, 2016), suggesting a particle-specific effect.…”