Bioaccumulation and in vivo formation of titanium dioxide nanoparticles in edible mussels

Gallocchio, Federica; Biancotto, Giancarlo; Moressa, Alessandra; Pascoli, Francesco; Pretto, Tobia; Toffan, Anna; Arcangeli, Giuseppe; Montesi, Francesco; Peters, Ruud; Ricci, Antonia

doi:10.1016/j.foodchem.2020.126841

Cited by 16 publications

(18 citation statements)

References 35 publications

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“…106 Specific metal cytotoxicity is evident from abundant in vitro and animal studies, e.g., TiO2 NPs produce upregulation of miR-29b-3p reinforcing apoptosis, imbalance in the Th1/Th2 cells, small intestine physical(ileum) barrier structural changes in a dose-dependent manner, and epigenetic changes. [107][108][109][110][111][112]55 Food sources of TiO2 NPs are substantial 107 , concentrations in food reportedly range from 3 to 2400 mg kg -1 with particle sizes between 30 to 410 nm.…”

Section: Discussionmentioning

confidence: 99%

Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem portal

Calderón‐Garcidueñas

González-Maciel

Reynoso-Robles

et al. 2020

Environmental Research

143

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Fine particulate air pollution (PM2.5) exposures are linked with Alzheimer's and Parkinson's diseases. AD and PD neuropathological hallmarks are documented in children and young adults exposed lifelong to Metropolitan Mexico City air pollution; together with high frontal metal concentrations (especially iron)-rich nanoparticles (NP), matching air pollution combustion and friction-derived particles. Here, we identify aberrant hyperphosphorylated tau, ɑ synuclein and TDP-43 in the brainstem of 186 Mexico City 27.29±11.8y old residents. Critically, substantia nigrae (SN) pathology seen in mitochondria, endoplasmic reticulum and neuromelanin (NM) is co-associated with the abundant presence of exogenous, Fe-, Al-and Ti-rich NPs.The SN exhibits early and progressive neurovascular unit damage and mitochondria and NM exogenous engineered Ti-rich nanorods, also identified in neuroenteric neurons. Such reactive, cytotoxic and magnetic NPs may act as catalysts for reactive oxygen species formation, altered cell signaling, and protein misfolding, aggregation and fibril formation. Hence, pervasive, airborne and environmental, metal-rich and magnetic nanoparticles may be a common denominator for quadruple misfolded protein neurodegenerative pathologies affecting urbanites from earliest childhood. The substantia nigrae is a very early target and the gastrointestinal tract (and the neuroenteric system) likely key brainstem portals. The ultimate neural damage and neuropathology (Alzheimer's, Parkinson's and TDP-43 pathology included) could depend on NP characteristics and the differential access and targets achieved via their portals of entry,thus where you live, what air pollutants you are exposed to, what you are inhaling and swallowing from the air you breath, what you eat, how you travel, and your occupational longlife history are key. Control of NP sources becomes critical.

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Section: Discussionmentioning

confidence: 99%

Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem portal

Calderón‐Garcidueñas

González-Maciel

Reynoso-Robles

et al. 2020

Environmental Research

143

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“…In relation to ecotoxicity studies in aquatic environments, the uptake of Ag 198,202 and Au 198 nanoparticles by Daphnia magna was studied by analysing the haemolymph of the daphnids, 202 as well as whole organisms after alkaline digestion with TMAH. 198 In the case of mussels, Gallochio et al 203 suggested the in vivo formation of TiO 2 nanoparticles after their exposure to both ionic and particulate titanium. Zebra fish 204,205 and trout 54 have also been used as target species for ecotoxicological studies with Ag, Au, TiO 2 and CeO 2 nanoparticles.…”

Section: Scenario 22: In Vitro In Vivo and Ex Vivo (Eco)toxicological Testsmentioning

confidence: 99%

Analytical applications of single particle inductively coupled plasma mass spectrometry: a comprehensive and critical review

et al. 2021

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“…The disposal of NMs leads to emissions to the environment, thereby increasing the potential for exposure of living organisms, including humans [ 7 ]. In particular, aquatic ecosystems, such as the marine environment, might be potential sinks for NMs, where the interaction with a variety of persistent organic pollutants (POPs) in the environment has recently aroused further concern [ 6 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…There is evidence that urban runoff waters and superficial waters are contaminated with TiO 2 NPs [ 7 , 17 ]. Furthermore, TiO 2 NPs are expected to be released in huge amounts in urban and industrial sewage and are estimated to reach a concentration of µg L −1 [ 8 ] in the aquatic environment.…”

Section: Introductionmentioning

confidence: 99%

Effect of TiO2 Nanoparticle on Bioaccumulation of ndl-PCBs in Mediterranean Mussels (Mitilus galloprovincialis)

Gallocchio

Moressa

Pascoli

et al. 2023

Animals

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The interaction of nanomaterials with pollutants in the marine environment might alter bioavailability, as well as toxicity, of both nanomaterials and pollutants, representing a risk, not only for marine organisms, but also for consumers through the marine food chain.The aim of this study was to evaluate the effect of titanium dioxide nanoparticles (TiO2NPs) in terms of bioaccumulation and toxicity on Mediterranean mussels (Mytilus galloprovincialis) exposed to six-indicator non-dioxin-like polychlorinated biphenyls (ndl-PCBs). Mussels were exposed to ndl-PCBs (20 µg/mL) (groups 3–4) or to a combination of ndl-PCBs (20 µg/mL) and TiO2NPs (100 µg/mL) (groups 5–6) for four consecutive days. TiO2NPs was detected in groups 5–6 (3247 ± 567 and 1620 ± 223 µg/kg respectively), but their presence did not affect ndl-PCBs bioaccumulation in mussels. In fact, in groups 3–4, the concentration of ndl-PCBs (ranging from 3818.4 ± 166.0–10,176 ± 664.3 µg/kg and 2712.7 ± 36.1–9498.0 ± 794.1 µg/kg respectively) was not statistically different from that of groups 5–6 (3048.6 ± 24.0–14,635.9 ± 1029.3 and 5726.0 ± 571.0–9931.2 ± 700.3 µg/kg respectively). Histological analyses showed alterations to the structure of the gill tissue with respect to the control groups, with more severe and diffuse dilatation of the central hemolymphatic vessels of the gill lamellae in groups 5–6 (treated with TiO2NPs and ndl-PCBs concurrently) compared to groups 3–4 (ndl-PCBs only). Finally, in mussels submitted to a seven-day depuration process, most TiO2NPs were eliminated, and NPs had a synergistic effect on ndl-PCBs elimination; as a matter of fact, in groups 5–6, the percentage of concentration was statically inferior to the one observed in groups 3–4. In any case, consumers might be exposed to TiO2NPs and ndl-PCBs (both concurrently and separately) if edible mussels, harvested in a contaminated environment, are consumed without a proper depuration process.

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Bioaccumulation and in vivo formation of titanium dioxide nanoparticles in edible mussels

Cited by 16 publications

References 35 publications

Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem portal

Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem portal

Analytical applications of single particle inductively coupled plasma mass spectrometry: a comprehensive and critical review

Effect of TiO2 Nanoparticle on Bioaccumulation of ndl-PCBs in Mediterranean Mussels (Mitilus galloprovincialis)

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