Bioaccumulation and biochemical response in South American native species exposed to zinc: Boosted regression trees as novel tool for biomarkers selection

Bertrand, Lidwina; Ramón, Adriana Noemí; Monferrán, Magdalena V.; Amé, María Valeria

doi:10.1016/j.ecolind.2016.03.048

Cited by 23 publications

(12 citation statements)

References 61 publications

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“…Despite the fact that in the last years there was an increase of the use of IBR indices both in plant and animals in laboratory experiments (Bertrand et al, 2016b(Bertrand et al, , 2017 or field studies (Santos et al, 2016), few of them are applied for defining processes or modes of toxicity. For example, for mussels IBR indices were developed for inmunotoxical (Auffret et al, 2006) and lysosomal biomarkers (Izagirre and Marigomez, 2009) to evaluate contaminated sites.…”

Section: Integrated Biomarker Responsementioning

confidence: 99%

An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid

Iturburu

Bertrand

Mendieta

et al. 2018

Ecological Indicators

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Integrated Biomarkers Response (IBR) index have been developed as a practical and robust tool to assess the susceptibility to pollutants using multiple biomarker responses. Neonicotinoid insecticides are nowadays one of the most sold pesticides worldwide. Nevertheless, imidacloprid (IMI) sub-lethal effects such as oxidative stress (OS) on fishes are scarcely studied. Hence, the aims of this work were: (1) to evaluate exposure-and damage biomarkers related to OS in the freshwater fish Australoheros facetus exposed to IMI and (2) to apply the IBR index to achieve a comprehensive understanding of OS in the fish. The results of the present study showed that all the biomarkers presented different responses in the three monitored tissues: liver, brain and gills. Results for an initial battery of 19 biomarkers were obtained and for the IBR index only those with significant differences have been considered. The biomarkers that had the most important weight on the IBR index were SOD activity in brain and gills, H 2 O 2 concentration in liver, and carbonyl groups concentration in gills in fishes exposed to 100 and 1000 μg L −1 IMI. This index allowed affirming that a short term exposure to environmentally relevant concentrations of IMI (≥10 μg L −1) produces OS in A. facetus. However, a more deep understanding of some biomarkers response is necessary to improve the index and for finally apply it in field studies.

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Section: Integrated Biomarker Responsementioning

confidence: 99%

An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid

Iturburu

Bertrand

Mendieta

et al. 2018

Ecological Indicators

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“…The aim of this analysis is to determine those effect biomarkers with higher capacity to explain or predict the exposure concentrations of CPF. Boosted regression trees (BRT) have been fitted according to procedure described by Bertrand et al (2016a). Briefly, the model was constructed with the GBM packages (Ridgeway, 2013) in R (version 0.98.953), using the code described by Elith et al (2008) including those biomarkers with significant differences to control condition.…”

Section: Boosted Regression Trees and Integrated Biomarkers Responsementioning

confidence: 99%

“…Nevertheless, the calculation of IBR needs a previous selection of biological responses to be considered. The use of boosted regression trees (BRTs) is a valid tool to select those biomarkers to be used in IBR (Bertrand et al, 2016a). Therefore, biomarkers from the three plant sectors with a significant variation respect to control condition were used to fit a BRT model.…”

Section: Boosted Regression Trees (Brt) and Integrated Biomarkers Resmentioning

confidence: 99%

Can a low concentration of an organophosphate insecticide cause negative effects on an aquatic macrophyte? Exposure of Potamogeton pusillus at environmentally relevant chlorpyrifos concentrations

Bertrand

Marino

Monferrán

et al. 2017

Environmental and Experimental Botany

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The contamination of the aquatic environments with organophosphorus pesticides may affect non-target organisms. The aim of this study was to evaluate the toxic effects of the insecticide chlorpyrifos (CPF) at environmental concentrations on the freshwater macrophyte Potamogeton pusillus belonging to a genus of worldwide distribution. For this purpose, individuals were exposed from 3.5 to 94.5 ng of CPF L À1 for 96 h. A battery of biochemical responses including bioaccumulation, defense and damage biomarkers were measured in leaf, stem and root. Even when CPF was not detected in the macrophyte tissues, our results showed that this insecticide promotes oxidative stress and biomolecule damages in P. pusillus after acute exposure. Significant response of biomarkers was observed from the lowest tested concentration (3.5 ng CPF L À1). Oxidative stress was evidenced by increased lipid peroxidation and antioxidant enzymatic activation, including changes in superoxide dismutase, guaiacol peroxidase and glutathione peroxidase activities, especially in leaf. Also, a significant decrease in chlorophyll a and b contents was observed mainly in leaf. Finally, with some selected biomarkers, an Integrated Biomarker Response index was calculated showing a dose-response relationship with CPF exposure. Previous studies reported that herbicides and organophosphorus pesticides are responsible for several effects on photosynthetic systems but at higher exposure concentrations than the tested in this study. These results draw attention to the need for more studies in toxic effects of insecticides on aquatic macrophytes, at low concentrations and different biological levels, since the protection guidelines would not be preserving these species.

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“…org). Previous studies reported Potamogeton capacity to evidence pollutants exposure under laboratory conditions (Bertrand et al, 2016(Bertrand et al, , 2017Costa et al, 2018;Monferr an et al, 2009). In a similar way, others authors described the usefulness of Potamogeton in passive monitoring programs, showing to be useful as a biological indicator while evaluating environmental deterioration (Demirezen and Aksoy, 2004;Harguinteguy et al, 2016;Munteanu and Munteanu, 2007).…”

Section: Introductionmentioning

confidence: 72%

Usefulness of a freshwater macrophyte (Potamogeton pusillus) for an environmental risk assessment in a multi-source contaminated basin.

et al. 2019

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Bioaccumulation and biochemical response in South American native species exposed to zinc: Boosted regression trees as novel tool for biomarkers selection

Cited by 23 publications

References 61 publications

An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid

An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid

Can a low concentration of an organophosphate insecticide cause negative effects on an aquatic macrophyte? Exposure of Potamogeton pusillus at environmentally relevant chlorpyrifos concentrations

Usefulness of a freshwater macrophyte (Potamogeton pusillus) for an environmental risk assessment in a multi-source contaminated basin.

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