Bioaccessibility of individual phenolic compounds in extra virgin argan oil after simulated gastrointestinal process

Rueda‐Robles, Ascensión; Cantarero, Samuel; Seiquer, Isabel; Cabrera–Vique, Carmen; Herrera, Manuela

doi:10.1016/j.lwt.2016.09.028

Cited by 21 publications

(13 citation statements)

References 33 publications

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“…The UPLC-ESI-MS/MS method was used to identify the different phenolic compounds [5] Treatment of the sample. A liquid-liquid extraction with final concentration was performed.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Determination of Polyphenolic Compounds by Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry and Antioxidant Capacity of Spanish Subtropical Fruits

Muñoz¹,

Álvarez²,

Oliveras‐López³

et al. 2018

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In an analysis of the seven types of subtropical fruits most consumed and produced in southern Spain, UPLC-ESI-MS/MS was used to quantify 14 phenolic species: five hydroxycinnamic acids, seven hydroxybenzoic acids and two flavonoids (quercetin and naringenin). In each case, in addition, antioxidant capacity was determined by FRAP, ABTS and DPPH. Of these fruits, carambola (or starfruit) presented the highest levels of phenolic compounds, cherimoya (custard apple) and kiwi were the richest in non-flavonoid phenolic compounds and papaya had the highest levels of the flavonoids studied.Higher mean values were recorded in home-grown fruits than in imported varieties by ABTS and DPPH methods. Persimmon's antioxidant capacity was well above that of the other fruits, according to our analyses.

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“…The UPLC-ESI-MS/MS method was used to identify the different phenolic compounds [5] Treatment of the sample. A liquid-liquid extraction with final concentration was performed.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Determination of Polyphenolic Compounds by Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry and Antioxidant Capacity of Spanish Subtropical Fruits

Muñoz¹,

Álvarez²,

Oliveras‐López³

et al. 2018

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“…In addition, coupled to cell line models enable studies of antioxidant cell markers and intestinal absorption, elucidating the potential impact of these compounds on human health (Borges, Cabrera-Vique, & Seiquer, 2015;Soler et al, 2010). Previously, our research group has applied successfully Caco-2 cell lines as a model to study absorption and metabolism in small intestine of minerals and trace elements, products of Maillard reaction and phenolic compounds from various foodstuff, including EVOO (Mesías, Seiquer, & Navarro, 2009;Rueda, Cantarero, Seiquer, Cabrera-Vique, & Olalla, 2017;Ruiz-Roca, Navarro, & Seiquer, 2008;Seiquer, Rueda, Olalla, & CabreraVique, 2015).…”

Section: Introductionmentioning

confidence: 99%

Study of the antioxidant potential of Arbequina extra virgin olive oils from Brazil and Spain applying combined models of simulated digestion and cell culture markers

Borges

Pereira

Cabrera–Vique

et al. 2017

Journal of Functional Foods

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a b s t r a c tA physiological approach to assessing the antioxidant potential of Arbequina EVOO from different zones of Brazil and Spain was performed, applying a combined model of simulated digestion and cell cultures, using the Caco-2 cell line. Our results showed an increasing of total phenolic content (TPC) and antioxidant properties promoted by the in vitro digestion. Preincubating Caco-2 cells with bioaccessible fractions of oils counteracted the cytotoxic effect promoted by an oxidising agent (t-BOOH), preserving cell viability and reducing the generation of reactive oxygen species (ROS). The protective effect on ROS production was associated with the antioxidant activity (DPPH assay), but no relation with the TPC of the digested samples was found. Differences in the parameters evaluated were observed among the samples, which were related to climatic characteristics of the production zones. It was concluded that transformations during the digestive process are important for establishing the antioxidant potential of the oils.

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“…A great amount of polyphenols might be transformed by mild alkaline conditions in the small intestine into other structures with completely different bioaccessibility, bioavailability and biological activity, and chemical properties (Rueda et al, ). The general nutritional qualities of olive and argan oils are likely to be identical, but argan oil fatty acid composition is much more homogenous and its nutritional value is less fluctuant.…”

Section: Discussionmentioning

confidence: 99%

“…Beside high antioxidant and monounsaturated fatty acid and polyunsaturated fatty acid content (45% and 35%, respectively), argan oil has many beneficial compounds such as polyphenols, phytosterols, and tocopherols (Cherki et al, ; Khallouki et al, ). Polyphenols such as caffeic acid, oleic acid, linoleic acid, oleuropein, vanillic acid, tyrosol, ferulic acid, syringic acid, p‐hydroxybenzoic acid, 3,4‐dihydroxybenzoic acid, catechol, resorcinol, and 4‐hydroxybenzyl have been also identified in virgin argan oil (Marfil et al, ; Rueda, Cantarero, Seiquer, Cabrera‐Vique, & Olalla, ). Caffeic acid has been proved to inhibit the murine macrophages‐mediated low‐density lipoprotein oxidation (Nardini et al, ).…”

Section: Introductionmentioning

confidence: 99%

The impact of argan oil on plasma lipids in humans: Systematic review and meta‐analysis of randomized controlled trials

Ursoniu

Sahebkar

Şerban

et al. 2017

Phytotherapy Research

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The study aims to investigate the effect of argan oil on plasma lipid concentrations through a systematic review of the literature and a meta-analysis of available randomized controlled trials. Randomized controlled trials that investigated the impact of at least 2 weeks of supplementation with argan oil on plasma/serum concentrations of at least 1 of the main lipid parameters were eligible for inclusion. Effect size was expressed as the weighted mean difference (WMD) and 95% confidence interval (95% CI). Meta-analysis of data from 5 eligible trials with 292 participants showed a significant reduction in plasma concentrations of total cholesterol (WMD: -16.85 mg/dl, 95% CI [-25.10, -8.60], p < .001), low-density lipoprotein cholesterol (WMD: -11.67 mg/dl, 95% CI [-17.32, -6.01], p < .001), and triglycerides (WMD: -13.69 mg/dl, 95% CI [-25.80, -1.58], p = .027) after supplementation with argan oil compared with control treatment, and plasma concentrations of high-density lipoprotein cholesterol (WMD: 4.14 mg/dl, 95% CI [0.86, 7.41], p = .013) were found to be increased. Argan oil supplementation reduces total cholesterol, low-density lipoprotein cholesterol, and triglycerides and increases high-density lipoprotein cholesterol levels. Additionally, larger clinical trials are needed to assess the impact of argan oil supplementation on other indices of cardiometabolic risk and on the risk of cardiovascular outcomes.

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Bioaccessibility of individual phenolic compounds in extra virgin argan oil after simulated gastrointestinal process

Cited by 21 publications

References 33 publications

Determination of Polyphenolic Compounds by Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry and Antioxidant Capacity of Spanish Subtropical Fruits

Determination of Polyphenolic Compounds by Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry and Antioxidant Capacity of Spanish Subtropical Fruits

Study of the antioxidant potential of Arbequina extra virgin olive oils from Brazil and Spain applying combined models of simulated digestion and cell culture markers

The impact of argan oil on plasma lipids in humans: Systematic review and meta‐analysis of randomized controlled trials

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