Bioabsorbable polymer optical waveguides for deep-tissue photomedicine

Nizamoğlu, Sedat; Gather, Malte C.; Humar, Matjaž; Choi, Myunghwan; Kim, Seonghoon; Kim, Ki Su; Hahn, Sei Kwang; Scarcelli, Giuliano; Randolph, Mark A.; Redmond, Robert W.; Yun, Seok Hyun

doi:10.1038/ncomms10374

Cited by 183 publications

(189 citation statements)

References 36 publications

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“…Several bioresorbable optical components have been developed, such as microlens arrays [2], diffraction gratings [3], reflective plates [1], photonic crystals [4], waveguides [5,6] and optical fibers [7,8].…”

Section: Introductionmentioning

confidence: 99%

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Sieno

Boetti

Mora

et al. 2017

Journal of Biophotonics

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In the last years bioresorbable materials are gaining increasing interest for building implantable optical components for medical devices. In this work we show the fabrication of bioresorbable optical fibers designed for diffuse optics applications, featuring large core diameter (up to 200 mm) and numerical aperture (0.17) to maximize the collection efficiency of diffused light. We demonstrate the suitability of bioresorbable fibers for timedomain diffuse optical spectroscopy firstly checking the intrinsic performances of the setup by acquiring the instrument response function. We then validate on phantoms the use of bioresorbable fibers by applying the MEDPHOT protocol to assess the performance of the system in measuring optical properties (namely, absorption and scattering coefficients) of homogeneous media. Further, we show an ex-vivo validation on a chicken breast by measuring the absorption and scattering spectra in the 500-1100 nm range using interstitially inserted bioresorbable fibers. This work represents a step toward a new way to look inside the body using optical fibers that can be implanted in patients. These fibers could be useful either for diagnostic (e. g. for monitoring the evolution after surgical interventions) or treatment (e. g. photodynamic therapy) purposes. Picture: Microscopy image of the 100 mm core bioresorbable fiber.

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Section: Introductionmentioning

confidence: 99%

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Sieno

Boetti

Mora

et al. 2017

Journal of Biophotonics

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“…Planar waveguides were fabricated from PLA and PLGA by first press melting a material to form a transparent film and then using laser cutting to make arbitrary shapes [136]. The waveguides were connected to a conventional optical fiber (Fig.…”

Section: Biodegradable Synthetic Polymer Waveguidesmentioning

confidence: 99%

Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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“…However, traditional silica fibers are not only non-degradable, but also fragile and brittle in nature, thus presenting a significant limitation as an implantable device[2]. Waveguides made from single traditional materials, such as poly(ethylene glycol) (PEG)[3], silk[4], agarose gel[5], and poly(L-lactic acid) (PLA)[6] have also been reported. However, due to the lack of an intrinsic cladding layer, single material waveguides tend to have high loss, resulting from significant interaction of the guided optical wave with surrounding medium (such as tissues in vivo ).…”

Section: Introductionmentioning

confidence: 99%

Flexible biodegradable citrate-based polymeric step-index optical fiber

et al. 2017

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Implanting fiber optical waveguides into tissue or organs for light delivery and collection is among the most effective ways to overcome the issue of tissue turbidity, a long-standing obstacle for biomedical optical technologies. Here, we report a citrate-based material platform with engineerable opto-mechano-biological properties and demonstrate a new type of biodegradable, biocompatible, and low-loss step-index optical fiber for organ-scale light delivery and collection. By leveraging the rich designability and processibility of citrate-based biodegradable polymers, two exemplary biodegradable elastomers with a fine refractive index difference and yet matched mechanical properties and biodegradation profiles were developed. Furthermore, we developed a two-step fabrication method to fabricate flexible and low-loss (0.4 db/cm) optical fibers, and performed systematic characterizations to study optical, spectroscopic, mechanical, and biodegradable properties. In addition, we demonstrated the proof of concept of image transmission through the citrate-based polymeric optical fibers and conducted in vivo deep tissue light delivery and fluorescence sensing in a Sprague-Dawley (SD) rat, laying the groundwork for realizing future implantable devices for long-term implantation where deep-tissue light delivery, sensing and imaging are desired, such as cell, tissue, and scaffold imaging in regenerative medicine and in vivo optogenetic stimulation.

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Bioabsorbable polymer optical waveguides for deep-tissue photomedicine

Cited by 183 publications

References 36 publications

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Toward biomaterial-based implantable photonic devices

Flexible biodegradable citrate-based polymeric step-index optical fiber

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