Bio-therapeutic Potential and Cytotoxicity Assessment of Pectin-Mediated Synthesized Nanostructured Cerium Oxide

Patil, Sandeep; Paradeshi, Jayasinh S.; Chaudhari, Prapti; Mishra, Satyendra; Chaudhari, Bhushan L.

doi:10.1007/s12010-016-2121-9

Cited by 66 publications

(34 citation statements)

References 51 publications

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“…Of the 17 evaluated studies of CeNP antimicrobial activity ( Table 1 ), seven used the principle of green chemistry with extracts of plants, fruits, and fungi [ 13 , 14 , 17 , 20 – 23 ]. The green synthesis route is considered important because it is nontoxic and of low cost and decreases the use of substances that are harmful to human health and the environment [ 14 , 22 ].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial Activity of Cerium Oxide Nanoparticles on Opportunistic Microorganisms: A Systematic Review

Farias

Santos

Sampaio

2018

BioMed Research International

116

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An evaluation of studies of biologically active nanoparticles provides guidance for the synthesis of nanoparticles with the goal of developing new antibiotics/antifungals to combat microbial resistance. This review article focuses on the physicochemical properties of cerium oxide nanoparticles (CeNPs) with antimicrobial activity. Method. This systematic review followed the Guidelines for Transparent Reporting of Systematic Reviews and Meta-Analyses. Results. Studies have confirmed the antimicrobial activity of CeNPs (synthesized by different routes) using nitrate or chloride salt precursors and having sizes less than 54 nm. Conclusion. Due to the lack of standardization in studies with respect to the bacteria and CeNP concentrations assayed, comparisons between studies to determine more effective routes of synthesis are difficult. The mechanism of CeNP action likely occurs through oxidative stress of components in the cell membrane of the microorganism. During this process, a valence change occurs on the CeNP surface in which an electron is gained and Ce4+ is converted to Ce3+.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial Activity of Cerium Oxide Nanoparticles on Opportunistic Microorganisms: A Systematic Review

Farias

Santos

Sampaio

2018

BioMed Research International

116

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“…These alternative procedures include plant‐mediated, fungus‐mediated, nutrient‐mediated, and biopolymer‐mediated synthesis . For example, Patil et al synthesized CeO 2 nanoparticles in presence of pectin, extracted from Indian red pomelo fruit peels, that acts as a reducing agent during the reaction . The obtained cerium oxide nanoparticles have a diameter ≤ 40 nm, with good antioxidant activity …”

Section: Inorganic Nano‐antioxidants For Biomedical Applicationsmentioning

confidence: 99%

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Martinelli

Pucci

Battaglini

et al. 2019

Adv Healthcare Materials

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Many central nervous system (CNS) diseases are still incurable and only symptomatic treatments are available. Oxidative stress is suggested to be a common hallmark, being able to cause and exacerbate the neuronal cell dysfunctions at the basis of these pathologies, such as mitochondrial impairments, accumulation of misfolded proteins, cell membrane damages, and apoptosis induction. Several antioxidant compounds are tested as potential countermeasures for CNS disorders, but their efficacy is often hindered by the loss of antioxidant properties due to enzymatic degradation, low bioavailability, poor water solubility, and insufficient blood–brain barrier crossing efficiency. To overcome the limitations of antioxidant molecules, exploitation of nanostructures, either for their delivery or with inherent antioxidant properties, is proposed. In this review, after a brief discussion concerning the role of the blood–brain barrier in the CNS and the involvement of oxidative stress in some neurodegenerative diseases, the most interesting research concerning the use of nano‐antioxidants is introduced and discussed, focusing on the synthesis procedures, functionalization strategies, in vitro and in vivo tests, and on recent clinical trials.

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“… Cerium nitrate hexahydrate and Olea europaea leaf extract Water Green synthesis [ 61 ] 13. Cerium nitrate solution, pectin and ammonia solution Water Bio polymer mediated synthesis [ 68 ] …”

Section: Synthesis Of Nanoceriamentioning

confidence: 99%

“…Polymer-mediated synthesis approach has also been taken by some researchers to synthesize nanoceria [ 64 – 67 ]. For example, Patil et al [ 68 ] used cerium nitrate, pectin, and ammonia solution as precursors to synthesize nanoceria. The synthesized nanoparticles were spherical having an average particle size of ≤ 40 nm.…”

Section: Synthesis Of Nanoceriamentioning

confidence: 99%

Synthesis and biomedical applications of nanoceria, a redox active nanoparticle

2019

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Background Nanoceria has recently received much attention, because of its widespread biomedical applications, including antibacterial, antioxidant and anticancer activity, drug/gene delivery systems, anti-diabetic property, and tissue engineering. Main body Nanoceria exhibits excellent antibacterial activity against both Gram-positive and Gram-negative bacteria via the generation of reactive oxygen species (ROS). In healthy cells, it acts as an antioxidant by scavenging ROS (at physiological pH). Thus, it protects them, while in cancer cells (under low pH environment) it acts as pro-oxidant by generating ROS and kills them. Nanoceria has also been effectively used as a carrier for targeted drug and gene delivery in vitro and in vivo models. Besides, nanoceria can also act as an antidiabetic agent and confer protection towards diabetes-associated organ pathophysiology via decreasing the ROS level in diabetic subjects. Nanoceria also possesses excellent potential in the field of tissue engineering. In this review, firstly, we have discussed the different methods used for the synthesis of nanoceria as these are very important to control the size, shape and Ce 3+ /Ce 4+ ratio of the particles upon which the physical, chemical, and biological properties depend. Secondly, we have extensively reviewed the different biomedical applications of nanoceria with probable mechanisms based on the literature reports. Conclusion The outcome of this review will improve the understanding about the different synthetic procedures and biomedical applications of nanoceria, which should, in turn, lead to the design of novel clinical interventions associated with various health disorders. Graphical abstract

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Bio-therapeutic Potential and Cytotoxicity Assessment of Pectin-Mediated Synthesized Nanostructured Cerium Oxide

Cited by 66 publications

References 51 publications

Antimicrobial Activity of Cerium Oxide Nanoparticles on Opportunistic Microorganisms: A Systematic Review

Antimicrobial Activity of Cerium Oxide Nanoparticles on Opportunistic Microorganisms: A Systematic Review

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Synthesis and biomedical applications of nanoceria, a redox active nanoparticle

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