Bio-synthesis, characterization and antibacterial studies of ZnO nanoparticles

Aswathy, B.; Vishnudasan, Dalia; Manoj, P K

doi:10.3139/146.111972

Cited by 1 publication

(1 citation statement)

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“…Figure shows the FTIR patterns of the product. Both ZnO-TQ0255 and ZnO-ibuprofen demonstrate new absorption peaks compared with the reported IR absorption peaks of ZnO. , In the IR spectra of ZnO-TQ0255, the wide peak at 3384 cm –1 is the stretching vibration peak of −OH, and the quadrupled peaks at 1597, 1553, 1507, and 1464 cm –1 are attributed to the skeleton vibration absorption peak of the benzene group in TQ0255. The absorption peak of 1385 cm –1 is attributed to the C–H in-plane bending vibration.…”

Section: Resultsmentioning

confidence: 99%

Ibuprofen-Loaded ZnO Nanoparticle/Polyacrylonitrile Nanofibers for Dual-Stimulus Sustained Release of Drugs

Chao

Zhang

Cheng

et al. 2023

ACS Appl. Nano Mater.

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Based on the opportunities of ibuprofen administration innovation and challenges associated with the construction of transdermal drug delivery systems using medicated nanoparticles and electrospun nanofiber membranes, we developed a transdermal drug delivery system comprising ibuprofen-loaded ZnO nanoparticles/polyacrylonitrile electrospun nanofiber membranes (ZnO-ibuprofen/PAN), which was dual-stimulus responsive, wherein both pH and temperature triggered drug release. ZnO-ibuprofen nanoparticles with high drug loading capacity (17.7%) were prepared at room temperature by a one-step method involving 4,4′-((4-(4H-1,2,4-triazol-4-yl) phenyl) azanediyl)dibenzoic acid, Zn(NO3)2·6H2O, and ibuprofen, following which electrospinning was conducted to generate the ZnO-ibuprofen/PAN nanofibers. The transdermal drug release behavior of the ZnO-ibuprofen/PAN electrospun nanofiber membranes in the normal (pH = 7.4, 37 °C) and inflammatory (pH = 6.5, 42 °C) tissue environment exhibited increased drug release rate at higher ambient temperatures and decreased pH following 24 h of drug release. The cumulative drug release rate of ZnO-ibuprofen/PAN electrospun fibers through porcine skin under inflammatory conditions reached 71.35% ± 2.96% after 24 h, thereby demonstrating their favorable transdermal permeation behavior. The cytotoxicity assays revealed that the nanofibers possessed excellent biocompatibility. Thus, the dual stimulus-responsive ZnO-ibuprofen/PAN can be an effective transdermal drug delivery carrier.

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Section: Resultsmentioning

confidence: 99%