Bio-stimuli-responsive multi-scale hyaluronic acid nanoparticles for deepened tumor penetration and enhanced therapy

Huo, Mengmeng; Li, Wenyan; Chaudhuri, Arka; Fan, Yuchao; Han, Xiaochen; Yang, Chen; Wu, Zhenghong; Qi, Xiaole

doi:10.1016/j.carbpol.2017.05.017

Cited by 30 publications

(16 citation statements)

References 43 publications

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“…Gelatin, a most extensively used natural polymer, is the substrate of MMP-2 (Akkoc et al, 2017), and degradation of gelatin nanoparticles by MMP-2 is applied in design of MMP-2 sensitive-size tunable nanovehicles. The surface-carrying strategy is tethering ultrasmall nanoparticles to the periphery of large nanoparticles to form a nanocomplex with raspberrylike structure Ruan et al, 2015a;Huo M. et al, 2017). Gelatin nanoparticles with size of about 150-200 nm (Madkhali et al, 2019), and surface-carrying strategy, is applied to link small nanovehicles, for example, gold nanoparticles, quantum dots, and dendrimers to the surface of gelatin nanoparticles.…”

Section: Matrix Metalloproteinases-2 Triggered Size Reductionmentioning

confidence: 99%

“…The HA/PAMAM nanosystems with a large scale of about 197 nm were stable during systematic circulation, and once reaching the tumor site, they were degraded by the highly expressed hyaluronidase. PAMAM dendrimers with a small size of 5.77 nm and positive charge were released (Huo M. et al, 2017). A small-sized dendrigraft-L-lysine dendrimer conjugated with DOX and indocyanine were wrapped into nitric oxide (NO) donor-modified hyaluronic acid nanoparticles, and the multistage-responsive nanoparticles could be rapidly degraded from approximately 330 nm to smaller sizes, most of which were at 35-60 nm after incubation with hyaluronidase (Hu et al, 2018c).…”

Section: Hyaluronidasementioning

confidence: 99%

“…Although larger nanoparticles with diameters of approximately 100-150 nm possess the advantages of passive tumor targeting via the EPR effect, improved pharmacokinetics profile, and prolonged blood circulation, they are inferior in deep diffusion in tumors due to huge distribution obstacle (Hu et al, 2018c;Yang et al, 2019). On the contrary, ultrasmall size nanoparticles of below 20 nm (Huo M. et al, 2017) or 10 nm (Yang et al, 2019) exhibit relatively higher penetration capability and interstitial transport. However, ultrasmall nanodrugs are rapidly eliminated from circulating blood through renal filtration, resulting in ineffective tumor accumulation (Hu et al, 2018a).…”

Section: Introductionmentioning

confidence: 99%

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Tumor-Microenvironment- Responsive Size-Shrinkable Drug-Delivery Nanosystems for Deepened Penetration Into Tumors

Cheng

et al. 2020

Front. Mol. Biosci.

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Over the years, the manipulation and clinical application of drug-delivery nanosystems for cancer diseases have attracted a rapid growth of academic research interests, and some nanodrugs have been approved for clinic application. Although encouraging achievements have been made, the potency of nanomedicines in cancer treatment is far from satisfaction, and one significant reason is the inefficient penetration of nanoparticles into solid tumors. Particle size is one of the most significant features that influence diffusion ability of the drug-delivery system in tumors. Size-shrinkable drug-delivery nanosystems possess a size-switchable property that can achieve passive targeting via the enhanced permeability and retention (EPR) effect and transform into ultrasmall particles in tumors for deep penetration into tumors. The tumor microenvironment is characterized by acidic pH, hypoxia, upregulated levels of enzymes, and a redox environment. In this review, we summarize and analyze the current research progresses and challenges in tumor microenvironment responsive size-shrinkable drug-delivery nanosystems. We further expect to present some meaningful proposals and enlightenments on promoting deep penetration into tumors of nanoparticles.

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Section: Matrix Metalloproteinases-2 Triggered Size Reductionmentioning

confidence: 99%

Section: Hyaluronidasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tumor-Microenvironment- Responsive Size-Shrinkable Drug-Delivery Nanosystems for Deepened Penetration Into Tumors

Cheng

et al. 2020

Front. Mol. Biosci.

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“…Hyaluronic acid (HA) is a polyanionic polysaccharide, which is biocompatible and safe for intravenous administration (Huo et al, 2017;Trujillo-Nolasco et al, 2019;Razavi and Huang, 2020). Besides this, HA has been widely used for the construction of tumor-targeting nanoparticles because it could specifically target CD44 receptors of tumor cells and facilitate cellular uptake (Huo et al, 2017;Cai et al, 2019;Zhang et al, 2020;Rangasami et al, 2021). The copolymer micelle is an amphiphilic molecule, which could self-assembly into a nanoparticle in aqueous solution (Zhang et al, 2016(Zhang et al, , 2017.…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma

Zhou

Dong

Song

et al. 2021

Front. Bioeng. Biotechnol.

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The application of combinational therapy breaks the limitation of monotherapy and achieves better clinical benefit for tumor therapy. Herein, a hyaluronic acid/Pluronic F68-based copolymer-mixed micelle was constructed for targeted delivery of chemotherapeutical agent docetaxel (PHDM) in combination with programmed cell death ligand-1(PD-L1) antibody. When PHDM+anti-PDL1 was injected into the blood system, PHDM could accumulate into tumor sites and target tumor cells via CD44-mediated endocytosis and possess tumor chemotherapy. While anti-PDL1 could target PD-L1 protein expressed on surface of tumor cells to the immune checkpoint blockade characteristic for tumor immunotherapy. This strategy could not only directly kill tumor cells but also improve CD8+ T cell level and facilitate effector cytokines release. In conclusion, the rational-designed PHDM+anti-PDL1 therapy strategy creates a new way for tumor immune-chemotherapy.

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“…A long blood circulation is one of the key factors for higher tumor accumulation [15,16]. Meanwhile, deep tumor penetration and efficient cell internalization are essential for improving efficacy of therapeutic nanoplatforms [17][18][19][20]. To satisfy the above requirements, numerous platforms have focused on incorporating different physiochemical properties, including shape turning [21][22][23][24], size regulation [25][26][27] and surface modification [28][29][30] during fabrication of nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

Soft Mesoporous Organosilica Nanoplatforms Improve Blood Circulation, Tumor Accumulation/Penetration, and Photodynamic Efficacy

et al. 2020

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To date, the ability of nanoplatforms to achieve excellent therapeutic responses is hindered by short blood circulation and limited tumor accumulation/penetration. Herein, a soft mesoporous organosilica nanoplatform modified with hyaluronic acid and cyanine 5.5 are prepared, denoted SMONs-HA-Cy5.5, and comparative studies between SMONs-HA-Cy5.5 (24.2 MPa) and stiff counterparts (79.2 MPa) are conducted. Results indicate that, apart from exhibiting a twofold increase in tumor cellular uptake, the soft nanoplatforms also display a remarkable pharmacokinetic advantage, resulting in considerably improved tumor accumulation. Moreover, SMONs-HA-Cy5.5 exhibits a significantly higher tumor penetration, achieving 30-μm deeper tissue permeability in multicellular spheroids relative to the stiff counterparts. Results further reveal that the soft nanoplatforms have an easier extravasation from the tumor vessels, diffuse farther in the dense extracellular matrix, and reach deeper tumor tissues compared to the stiff ones. Specifically, the soft nanoplatforms generate a 16-fold improvement (43 vs. 2.72 μm) in diffusion distance in tumor parenchyma. Based on the significantly improved blood circulation and tumor accumulation/penetration, a soft therapeutic nanoplatform is constructed by loading photosensitizer chlorin e6 in SMONs-HA-Cy5.5. The resulting nanoplatform exhibits considerably higher therapeutic efficacy on tumors compared to the stiff ones.

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Bio-stimuli-responsive multi-scale hyaluronic acid nanoparticles for deepened tumor penetration and enhanced therapy

Cited by 30 publications

References 43 publications

Tumor-Microenvironment- Responsive Size-Shrinkable Drug-Delivery Nanosystems for Deepened Penetration Into Tumors

Tumor-Microenvironment- Responsive Size-Shrinkable Drug-Delivery Nanosystems for Deepened Penetration Into Tumors

Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma

Soft Mesoporous Organosilica Nanoplatforms Improve Blood Circulation, Tumor Accumulation/Penetration, and Photodynamic Efficacy

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