Bio-recognition and detection using liquid crystals

Hussain, Abid; Pina, Ana Sofia; Roque, Ana C. A.

doi:10.1016/j.bios.2009.04.038

Cited by 92 publications

(42 citation statements)

References 35 publications

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“…In general, interfacial interactions between LCs and bio-samples (or sensing targets) are the key to design a biosensor using nematic LCs [2][3][4][5][6][7]. Such an interfacial interaction often causes the re-orientations of LC molecules at the interface.…”

Section: Biosensors Using Nematic Liquid Crystalsmentioning

confidence: 99%

“…such as biotin/antibiotin-IgG, phosphopeptide, DNA, proteins, phospholiqid, bacteria and viruses, human embryonic stem cells, and protein-peptide binding events [6,[8][9][10][11][12][13][14][15]. The thermotropic nematic LC materials are soft condensed materials which have to be sustained in reservoirs and it takes times to sense the biosamples (30 min ~ few hours).…”

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confidence: 99%

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Liquid Crystals for Bio-medical Applications

Lin

2014

Topics in Applied Physics

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Thermotropic nematic LCs can modulate light in phases, amplitudes, and polarizations [1]. Many photonic applications based LCs have developed, such as displays, electro-optical switches, lenses, optical vortex generators, variable optical attenuations, solar cells and so on. Thermotropic nematic LCs have great potential in bio-medical applications. In this session, we mainly introduce two the bio-medical applications based on thermotropic nematic LCs: biosensors and ophthalmic lenses. In biosensors, the key is interfacial interactions between biosamples and LC molecules. We will introduce a LC and polymer complex system, the LC and polymer composite film (LCPCF), whose surface free energy is electrically switchable. LCPCF can help to test the sperm quality and high-density-lipoprotein (HDL). In ophthalmic applications, we will introduce the challenges and requirements for design of ophthalmic lenses. A polarizer-free LC lens with large aperture size is also introduced. Biosensors Using Nematic Liquid CrystalsIn general, interfacial interactions between LCs and bio-samples (or sensing targets) are the key to design a biosensor using nematic LCs [2][3][4][5][6][7]. Such an interfacial interaction often causes the re-orientations of LC molecules at the interface. As a result, optical properties of LC change and the change of the orientation of LC can be read out by observing under a polarizing microscopy. LC can optically amplify the biological binding events and help us to study the biology. The main approach is to immobilize thermotropic nematic LC onto a solid surface as a sensing interface for bio-samples. 5CB is a commonly used a LC material for biosensing. In the literatures, 5CB has been proved for sensing many bio-samples,

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Section: Biosensors Using Nematic Liquid Crystalsmentioning

confidence: 99%

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confidence: 99%

Liquid Crystals for Bio-medical Applications

Lin

2014

Topics in Applied Physics

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“…Immersion of colloid particles into a nematic system disturbs the orientational order and creates topological defects, which enforce fascinating self-assembly phenomena [26,30], with many potential applications [29,33]. This sensitivity to inclusion of small foreign bodies also has promising biomedical applications [40]: for instance, new biological sensors could detect very quickly the presence of microbes, based on the induced change in nematic order [14,15,35].…”

Section: Introductionmentioning

confidence: 99%

Minimizers of the Landau–de Gennes Energy Around a Spherical Colloid Particle

Alama

Bronsard

Lamy

2016

Arch Rational Mech Anal

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“…In optical metrology, birefringent materials have been widely utilized in the design of sensing transducers, particularly in angle, refractive index, spectra, and bio reaction sensors [11][12][13][14][15][16]. The phase delay between two orthogonal polarizations (s-and p-wave) is dependent on the incident angle, birefringence, relative refractive index, and wavelength.…”

Section: Introductionmentioning

confidence: 99%

Design and Characterization of a Birefringent-Type Compact Displacement Sensor for Improving Measurement Sensitivity by a Guided-Wave Beam

Twu

Yan

2017

Applied Sciences

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A compact displacement sensor (CDS) fabricated with the combinations of a birefringent KTP and cylindrical lens is proposed to be applied for optical displacement measurements in a common-path interferometer. To overcome the beam distortion issues of an original laser beam (OLB) in the small radius of the lens, a guided-wave beam (GWB) is proposed to demonstrate that the GWB (having better measurement characteristics than the OLB) is essential to achieve the improved sensitivity of displacement measurements performed by the CDS.

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Bio-recognition and detection using liquid crystals

Cited by 92 publications

References 35 publications

Liquid Crystals for Bio-medical Applications

Liquid Crystals for Bio-medical Applications

Minimizers of the Landau–de Gennes Energy Around a Spherical Colloid Particle

Design and Characterization of a Birefringent-Type Compact Displacement Sensor for Improving Measurement Sensitivity by a Guided-Wave Beam

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