Bio-Pulsed Stimulation Effectively Improves the Production of Avian Mesenchymal Stem Cell-Derived Extracellular Vesicles That Enhance the Bioactivity of Skin Fibroblasts and Hair Follicle Cells

Shieh, Ju-Sheng; Chin, Yu Tang; Chiu, Hsien‐Chung; Hsieh, Ya-Yu; Cheng, Hui-Rong; Gu, Hui

doi:10.3390/ijms232315010

Cited by 7 publications

(2 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 56 Polygonum multiflorum Thunb extract, which is bio-pulsed reagents, could improve production of chicken embryonic mesenchymal stem cell EVs, and thus enhance the proliferation of human DPCs in vitro, increase expression of follicle activity-related genes IGF-1 and RAC1, cell proliferative genes PNCA and CCND1, and decrease the expression of apoptosis genes TP53 and CASP2 in DPCs. 57 A case report shows that human placenta mesenchymal stem cell EVs could have an effect on permanent chemotherapy-induced alopecia. 58 …”

Section: The Progress Of Exosomes Applied In Hair Growthmentioning

confidence: 99%

The Roles of Exosomes in Regulating Hair Follicle Growth

Cheng,

Ma,

Chen

et al. 2024

CCID

View full text Add to dashboard Cite

Section: The Progress Of Exosomes Applied In Hair Growthmentioning

confidence: 99%

The Roles of Exosomes in Regulating Hair Follicle Growth

Cheng,

Ma,

Chen

et al. 2024

CCID

View full text Add to dashboard Cite

“…Another approach is to pretreat exosome-producing cells to alter exosome properties. Several studies have shown that the pretreatment of MSCs with drugs, cytokines, and physical factors can enhance the effect of MSCs and their exosomes in promoting tissue regeneration [71,[200][201][202][203][204][205][206][207]. The pretreatment method is technically more straightforward, safer, and more universal than genetically engineered exosomes.…”

Section: Engineered Exosomesmentioning

confidence: 99%

Exosomes and Their Bioengineering Strategies in the Cutaneous Wound Healing and Related Complications: Current Knowledge and Future Perspectives

Yang¹,

Waheed²,

Shekh³

et al. 2023

Int. J. Biol. Sci.

View full text Add to dashboard Cite

Exosomes, as therapeutically relevant cell-secreted extracellular vesicles, have attracted enormous interest because they participate in intercellular communication and facilitate wound healing. Stem cell-derived exosomes exhibit similar biological effects to source cells with the exception of low immunogenicity and no tumorigenicity, as well as superior efficacy in promoting wound healing. Exosomes accelerate wound healing by promoting angiogenesis and cell proliferation, as well as balancing inflammatory responses. Particularly, when exosomes are genetically modified or used in combination with materials, they can exhibit better comprehensive therapeutic properties, such as enriching active ingredients, targeted delivery, and physiological barrier to penetration, which are not available in traditional single products. Besides, exosomes have also been considered for diagnostic and therapeutic uses related to wounds, such as repairing complex wounds, enhancing graft success, treating related complications, and serving as diagnostic biomarkers. However, their clinical applications still face challenges, as reliable commercial products are not yet available. This review will focus on recent research advances that describe the characteristics and isolation of exosomes, introduce the sources of exosomes suitable for wound repair and related complications, illustrate the value of engineered exosomes and their development directions in the future, and provide evidence for the potential therapeutic application of exosomes in wound healing, as well as discuss potential risks, challenges, and solutions for future applications.

show abstract

Clinical applications of exosomes in cosmetic dermatology

Bai,

Truong,

Pathak

et al. 2024

Skin Health and Disease

View full text Add to dashboard Cite

IntroductionExosomes are extracellular vesicles that transport bioactive substances during normal and abnormal cellular physiological processes. The unique properties of exosomes can be exploited for use as biomarkers and targeted drug delivery vehicles, and are, for this reason, gaining increasing attention in the field of dermatology. This review aims to synthesise the existing evidence supporting exosomes in regenerative and cosmetic dermatology.MethodA comprehensive PubMed search for the period of 2010–2023 was performed using the MeSH terms "exosome" and "skin.” The initial search yielded 246 studies, which were then refined to 178 studies following title and abstract screening. Studies were confined to human or animal studies published in English that evaluated the use of exosomes in medical/cosmetic dermatology. A subsequent full‐text review based on these criteria yielded 34 studies, which were then reviewed.ResultsExosomes can be derived from a variety of biological sources and show potential application in wound healing, scar prophylaxis, photodamage prevention, skin regeneration, improved grafting success, hair loss mitigation, and as biomarkers and drug carriers.ConclusionExosomes are gaining traction in regenerative and cosmetic dermatology. However, their widespread clinical application is hindered by cost, a complex isolation process, lack of uniform protocols, limited assessment of infective potential, and a paucity of clinical evidence. Further research in this area is needed, especially by way of clinical studies evaluating the efficacy of exosome‐based treatments on human skin.

show abstract

Bio-Pulsed Stimulation Effectively Improves the Production of Avian Mesenchymal Stem Cell-Derived Extracellular Vesicles That Enhance the Bioactivity of Skin Fibroblasts and Hair Follicle Cells

Cited by 7 publications

References 67 publications

The Roles of Exosomes in Regulating Hair Follicle Growth

The Roles of Exosomes in Regulating Hair Follicle Growth

Exosomes and Their Bioengineering Strategies in the Cutaneous Wound Healing and Related Complications: Current Knowledge and Future Perspectives

Clinical applications of exosomes in cosmetic dermatology

Contact Info

Product

Resources

About