Bio-orthogonally crosslinked catechol–chitosan hydrogel for effective hemostasis and wound healing

Li, Hang; Zhou, Xujie; Luo, Lei; Ding, Qiang; Tang, Shunqing

doi:10.1016/j.carbpol.2021.119039

Cited by 66 publications

(34 citation statements)

References 45 publications

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“…15 Chitosan usually acts as a cross-linker with aldehydes and diisocyanate functional biopolymers to prepare hydrogels. 3 Many chemical modified methods have been taken on chitosanbased hydrogels to improve their hemostasis and adhesion performance, including catechol [16][17][18][19][20][21][22][23] and pyrogallol [24][25][26] decoration, amino 27 and aldehyde 28 modification, photoactive methacrylate 17,[29][30][31][32][33] and o-nitrobenzyl 34 functionalization, etc. For example, Peng et al 35 fabricated a polyethyleneimine/polyacrylic acid/quaternized chitosan (PEI/PAA/QCS) powder through a freeze drying-grinding procedure with ultrafast self-gelling and wet adhesive properties (Fig.…”

Section: Chitosanmentioning

confidence: 99%

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

Mao

et al. 2022

J. Mater. Chem. B

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Section: Chitosanmentioning

confidence: 99%

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

Mao

et al. 2022

J. Mater. Chem. B

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“…Polyethylene glycol (PEG) is a tunable macromolecular compound with multiple functional groups. Li et al attached catechol-modified chitosan to PEG to form hydrogels with stronger mechanical properties (Li et al, 2022). The material preparation method is shown in Table 1.…”

Section: Chitosan-based Materials For Hemostasis 41 Hydrogelsmentioning

confidence: 99%

Application of chitosan-based materials in surgical or postoperative hemostasis

et al. 2022

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Uncontrolled bleeding from trauma or surgery remains an important factor affecting the survival and prognosis of surgical patients. Failure to timeously stop bleeding will not only prolong the operative time but also threaten the patient’s life. Timely hemostasis after bleeding has become the most concerned event for surgeons. At present, the most commonly used hemostasis methods in the operating room include ligation of blood vessels, electrocautery, and gauze compression to stop bleeding. However, These hemostatic methods do great harm to surrounding tissues while achieving hemostasis. Based on tissue engineering repair strategies, the use of natural polymer materials as hemostatic agents has achieved clinical success. Gelatin sponge and cellulose gauze have been used clinically with good results. However, gelatin sponges are very expensive and place enormous financial pressure on patients. Therefore, there is an urgent need for new hemostatic materials for surgical hemostasis. Chitosan is a natural polysaccharide with biocompatibility and biodegradability, which plays an important role in tissue engineering and regenerative medicine. Chitosan gauze has been proven to have good hemostatic effects. The positive charge on the surface of chitosan can adsorb red blood cells and platelets at the bleeding site to form platelet thrombosis. However, chitosan is not easily soluble in water and has poor adsorption, which makes it a weak local hemostatic agent. Therefore, it is important to improve chitosan-based hemostatic material such that it l has an excellent hemostatic effect. In this review, we introduce the physiological coagulation process and discuss the physicochemical properties of chitosan and its role in hemostasis. Furthermore, we discuss the advantages and disadvantages of chitosan-based hemostatic materials. Finally, we summarize and discuss chitosan-based hemostatic materials.

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“…On days 1, 5, 10, and 15, three rats were randomly killed and skin tissues were collected for further analysis. 46 Wound healin grate %…”

Section: Wound Healing In the Bodymentioning

confidence: 99%

N‐2‐hydroxypropyl trimethyl ammonium chloride chitosan‐glycerol complex temperature‐sensitive hydrogel for wound dressing

Wang

Yan

Jin

et al. 2022

J of Applied Polymer Sci

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With the development of the times, it becomes difficult or even impossible for traditional wound dressings to meet people's needs for high-quality wound repair and management. Therefore, there is an urgent need for new biomedical dressings that can accelerate wound healing in clinical practice. In this study, N-2-hydroxypropyl trimethylammonium chloride chitosan (N-2-HACC), a derivative of chitosan, was used as raw material to sprepare N-2-HACC temperature sensitive hydrogel. The structure, thermal stability and water content of N-2-HACC temperature sensitive hydrogel were analyzed by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and differential scanning calorimetry. The safety of N-2-HACC temperature sensitive hydrogel was evaluated by in vitro cell assay and in vitro degradation assay, and the effect of N-2-HACC temperature sensitive hydrogel on wound healing was evaluated by wound healing experiment in SD rats. The results show that N-2-HACC hydrogel, as a wound dressing, has the characteristics of good biocompatibility, good biodegradation, non-toxic, antiinflammatory and so on. It plays a barrier role in the process of wound healing, provides a moist environment for the wound and accelerates wound healing. Therefore, N-2-HACC hydrogel has a broad application prospect in promoting wound healing as a wound dressing.

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Bio-orthogonally crosslinked catechol–chitosan hydrogel for effective hemostasis and wound healing

Cited by 66 publications

References 45 publications

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

Application of chitosan-based materials in surgical or postoperative hemostasis

N‐2‐hydroxypropyl trimethyl ammonium chloride chitosan‐glycerol complex temperature‐sensitive hydrogel for wound dressing

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