Bio-oriented synthesis of ibuprofen derivatives for enhancement efficacy in post-operative and chronic inflammatory pain models

Abstract

Post-operative and chronic inflammatory activity of ibuprofen derivatives in pain in vivo models.

Muscle relaxant and antipyretic effects of pentacyclic triterpenes isolated from the roots of Diospyros lotus L

“…Increased body temperature further progress the disease status by increasing tissue catabolism, and dehydration [ 12 , 19 ]. Antipyretic drugs inhibit the expression of cyclooxygenase 2 (COX-2) enzyme, thus the synthesis of prostaglandin is stopped, as a result the elevated body temperature is lowered [ [20] , [21] , [22] , [23] ]. Although synthetic antipyretic drugs selectively inhibit COX-2, however, they have also shown toxic effects on several organs (glomeruli, brain cortex, heart, and hepatic cells).…”