Abstract:Triazole-based acetamides serve as important scaffolds for various pharmacologically active drugs. In the present work, structural hybrids of 1,2,4-triazole and acetamides were furnished by chemically modifying 2-(4-isobutylphenyl) propanoic acid (1). Target compounds 7a–f were produced in considerable yields (70 –76%) by coupling the triazole of compound 1 with different electrophiles under different reaction conditions. These triazole-coupled acetamide derivatives were verified by physiochemical and spectrosc… Show more
“…The exhaustiveness was set to be 8. The main docking calculation was performed via AutoDock Vina [10] . More so, the correlation between the descriptors and the calculated binding affinities were executed using Microsoft Excel and the correlation with R 2 ≥ 0.5 was reported.…”
Section: Experimental Design Materials and Methodsmentioning
“…The exhaustiveness was set to be 8. The main docking calculation was performed via AutoDock Vina [10] . More so, the correlation between the descriptors and the calculated binding affinities were executed using Microsoft Excel and the correlation with R 2 ≥ 0.5 was reported.…”
Section: Experimental Design Materials and Methodsmentioning
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.