Bio-organic mechanisms: II. Chemoreception

Ferguson, Lloyd N.

doi:10.1021/ed058p456

Cited by 8 publications

(18 citation statements)

References 13 publications

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“…The two neurotransmitters, acetylcholine (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) and carbachol (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), have similar muscarinic action. The two neurotransmitters, acetylcholine (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) and carbachol (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)…”

Section: Molecular Adaptationmentioning

confidence: 99%

“…5-Fluorocytosine (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) is an analog of cytosine (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) that is commonly used as an antibiotic against bacterial infections. One serious problem in drug design is to develop a therapy that will not harm the patient's tissues but will destroy the infecting cells or bacteria.…”

Section: Molecular Adaptationmentioning

confidence: 99%

“…The solvolysis of acetates (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13) and (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) in CH30H/Et3N showed a marked preference for the molecule having a P-OH group at carbon 5 where the rate of hydrolysis is 300 times faster. The solvolysis of acetates (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13) and (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) in CH30H/Et3N showed a marked preference for the molecule having a P-OH group at carbon 5 where the rate of hydrolysis is 300 times faster.…”

mentioning

confidence: 99%

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Bioorganic Chemistry

Dugas¹

1989

Springer Advanced Texts in Chemistry

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Section: Molecular Adaptationmentioning

confidence: 99%

Section: Molecular Adaptationmentioning

confidence: 99%

mentioning

confidence: 99%

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Bioorganic Chemistry

Dugas¹

1989

Springer Advanced Texts in Chemistry

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“…It has been proposed that these analogs interact with a receptor site as diagrammed in 17 in which X and Y of 1 represent the SHALLENBERGER A-H,B moiety and the Z-phenyl portion is involved in hydrophobic bonding to the receptor (35).…”

Section: Sweetmentioning

confidence: 99%

“…Sweet (78) Sweet (35) Sweet (35) An A-H,B segment can easily be picked out in 21 and 22 which are sweet (37), but the Z fragment would be unusual.…”

mentioning

confidence: 99%

Some SAR studies on the sense of taste

Ferguson

Lang

Morga

et al. 1984

Carlsberg Res. Commun.

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Using the Shallenberger-Kier model as a molecular requirement for the sweet taste, adsorption and spectroscopic measurements on sweet and nonsweel analogs are described. Additional exploratory experiments were made in search of a set of parameters which could be used to predict the taste (sweet or nonsweet) oftrisubstituted benzenes. INTRODUCTIONScientists of diverse disciplines are studying the sense of taste, essentially from three different perspectives. There are those, primarily organic chemists, who seek structure-taste relationships (SAR). A sub-group, "flavor chemists", analyze foods and examine the effects of flavor-enhancers, flavor-inhibitors, and flavor modifiers. A second category of interest is the mechanism of taste stimulation, being explored by biochemists, biophysicists and others. They are probing the mechanism of stimulus-receptor interaction, cell structure of the taste buds, and the triggering process of nerve transmission up to the brain. Thirdly, there are those interested in taste perception, especially psychologists. This includes the measurements of taste quality and intensity, taste preferences, and food flavors.Recent work has shown that for a clearer elucidation of the mechanism of taste stimulation by sweet or bitter substances, studies must be made of (1) structure-activity relationships of the stimulus,'{2) the rate of development (reaction time), intensity, and longevity of response to the stimulus Cpersistance'), (3) the nature of the stimulus-receptor interaction. (4) The influence of biosphere environment, i.e. ionic strength, viscosity, temperature, concentration of stimulus, etc., (5) biochemical factors affecting transduction of the nerve impulses to the brain, e.g. presence of critical enzymes, etc. As organic chemists, we have been particulary interested in the first and third factors above.With respect to the sweet taste, a widely used working hypothesis has been that sweet molecules have a triangular region, A-H, B, y, in which A-H is a proton-donor group, B a proton-acceptor function and y is a lipophilic moiety (46,70).

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Disproportionation of O‐Benzylhydroxylamine Catalyzed by a Ferric Bis‐Picket Fence Porphyrin Complex

McQuarters¹,

Goodrich²,

M.³

et al. 2013

Zeitschrift anorg allge chemie

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Abstract. Hydroxylamine (NH 2 OH) is an important molecule in biology that serves as an intermediate in the nitrogen cycle, and that can also be utilized as a nitric oxide donor in mammals under certain conditions. In light of this, the interaction of NH 2 OH with hemes in proteins and model systems has gained much attention recently. In this study, we use the more stable, oxygen substituted O-benzylhydroxylamine (NH 2 OBn) as a model for NH 2 OH. Here, the reactivity of the ferric bis-picket fence porphyrin complexes [Fe(3,5-Me-BAFP)(ClO 4 )] (1) and [Fe(3,5-Me-BAFP)(PF 6 )] (2) (3,5-Me-BAFP 2-= dianion of tetra(2,6-bis(3,5-dimethylphenoxy)phenyl)porphyrin)) with NH 2 OBn

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Bio-organic mechanisms: II. Chemoreception

Cited by 8 publications

References 13 publications

Bioorganic Chemistry

Bioorganic Chemistry

Some SAR studies on the sense of taste

Disproportionation of O‐Benzylhydroxylamine Catalyzed by a Ferric Bis‐Picket Fence Porphyrin Complex

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