Bio-modified TiO2 nanoparticles with Withania somnifera, Eclipta prostrata and Glycyrrhiza glabra for anticancer and antibacterial applications

Maheswari, Palanisamy Uma; Harish, S.; Navaneethan, M.; Muthamizhchelvan, C.; Ponnusamy, S.; Hayakawa, Y.

doi:10.1016/j.msec.2019.110457

Cited by 44 publications

(17 citation statements)

References 74 publications

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“…A similar pattern of results on the cell cytotoxicity of NPs was reported by Maheswaria et al [26], Murugan et al [27] and Sukirtha et al [28]. In line with previous in vitro studies indicating that the TiO 2 NPs are toxic to the mammalian cells [29], the results of the present study provide evidence of a profound cytotoxic effect of synthesized TiO 2 NPs against the breast cancer MCF-7 cell line in comparison to Vinblastine.…”

Section: Evaluation Of Cytotoxicity and Antibacterial Activities Of Tsupporting

confidence: 92%

Eco-synthesis and characterization of titanium nanoparticles: Testing its cytotoxicity and antibacterial effects

Eisa

Almansour

Alnaim

et al. 2020

Green Processing and Synthesis

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In recent years, green synthesis of nanoparticles has been the cornerstone of development of nanotechnology and its applications, as it emphasizes on promoting environmental sustainability. The aim of the present study was to investigate the potential health benefits of the green-synthesized titanium nanoparticles (TiO2NPs). TiO2NPs were synthesized using titanium(iv) isopropoxide and lupin bean extract. The synthesized particles were characterized to assess the average particle size by dynamic light scattering, and X-ray diffraction method was used to study the crystalline nature. The average particle size recorded was 9.227 nm with a polydispersity index (PDI) of 0.382. The morphology of the particles was assessed by scanning electron microscope and transmission electron microscopy which showed varied shapes of the nanoparticles, uniform spherical and crystallite rod shaped. Further, the cytotoxic efficacy of the nanoparticles was assessed against the breast cancer (MCF-7) cell line using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidefor (MTT) assay. The antibacterial activity of the nanoparticles was evaluated against clinical pathogens via the disc diffusion assay. The key findings showed that the TiO2NPs exhibited potent cytotoxicity against the MCF-7 cell line with an IC50 of 41.1 µg. It also showed profound antibacterial activity. Thus, the synthesized nanoparticles could have potential biomedical applications owing to their therapeutic efficacy.

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Section: Evaluation Of Cytotoxicity and Antibacterial Activities Of Tsupporting

confidence: 92%

Eco-synthesis and characterization of titanium nanoparticles: Testing its cytotoxicity and antibacterial effects

Eisa

Almansour

Alnaim

et al. 2020

Green Processing and Synthesis

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“…This crystallographic form of TiO2NTs has been reported as a highly organized structure that favours the nucleation of hydroxyapatite, the inorganic component of bone tissue, supporting the osseointegration process [7,[26][27][28][29][30]. Although the electrochemical anodization is a useful approach to improve the biocompatibility and osteogenesis, as it provides an appropriate microenvironment for the fixation of bone cells, previous studies have demonstrated the great advantages of TiO2 surface functionalized with biocompatible and bioactive molecules [7,[31][32][33][34]. This procedure has been shown to reduce the postoperative infection and improve the biocompatibility and osseointegration of the implant [7].…”

Section: Resultsmentioning

confidence: 94%

The Deposition of a Lectin from <em>Oreochromis niloticus</em> on the Surface of Titanium Dioxide Nanotubes Improve the Cell Adhesion, Proliferation, and Osteogenic Activity of Osteoblast-like Cells

Anjos¹,

Silva²,

Souza³

et al. 2021

Preprint

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Titanium and its alloys are used biomaterials for medical and dental applications, due to their mechanical and physical properties. The surface modifications of titanium with bioactive molecules can increase the osseointegration by improving the interface between the bone and implant. Titanium dioxide nanotubes (TiO2NTs) have excellent bioactivity inducing cell adhesion, spreading, growth and differentiation. In this work, TiO2NTs were functionalized with a lectin from the plasma of the fish Oreochromis niloticus aiming to favour the adhesion and proliferation of osteoblast-like cells, improving its biocompatibility. The TiO2NTs were obtained by anodization of titanium and annealed at 400 °C for 3 h. The resulting TiO2NTs were characterized by high-resolution scanning electron microscopy. The successfully incorporation of OniL on the surface of TiO2NTs by spin coating was demonstrated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIE) and attenuated total reflection-Fourier transform infrared spectrum (ATR-FTIR). Our results showed that TiO2-NTs were successfully synthesized in a regular and well-distributed way. The functionalization of TiO2-NTs with OniL favoured adhesion, proliferation, and the osteogenic activity of osteoblast-like cells, suggesting its use to improve the quality and biocompatibility of titanium-based biomaterials.

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“…A wide variety of NPs were proven to be effective against a number of oral cancer cell lines, including human Caucasian dysplastic oral keratinocytes (DOK) [ 205 , 207 ], mouth epidermoid carcinoma (KB) [ 203 , 208 , 209 , 210 , 211 , 212 ], murine AT-84 oral squamous carcinoma cells [ 213 ], oral squamous cancer cell lines of Asian origin (ORL-48 and ORL-115) [ 214 ], human oral squamous cell carcinoma lines (PE/CA-PJ15 [ 215 ], OEC-M1 [ 216 ], HSC2 [ 217 ], YD-9 [ 218 ], SAS [ 219 , 220 ], HSC4 [ 1 , 220 ], KOSC [ 220 ], HSC3 [ 204 , 221 , 222 ], HSC-3-M3 [ 7 ], Ca9-22 [ 223 ], CAL 27 [ 222 , 223 , 224 , 225 , 226 , 227 ], SCC131 [ 228 ], SCC4 [ 222 , 228 ], VB6 [ 229 ], and H357 [ 229 , 230 , 231 ]), human tongue carcinoma cell lines (SCC-9 [ 232 , 233 , 234 ], SCC-25 [ 224 , 230 , 233 , 235 ], SCC-15 […”

Section: Head Neck and Oral Cancermentioning

confidence: 99%

Nanoparticles in Dentistry: A Comprehensive Review

2021

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In recent years, nanoparticles (NPs) have been receiving more attention in dentistry. Their advantageous physicochemical and biological properties can improve the diagnosis, prevention, and treatment of numerous oral diseases, including dental caries, periodontal diseases, pulp and periapical lesions, oral candidiasis, denture stomatitis, hyposalivation, and head, neck, and oral cancer. NPs can also enhance the mechanical and microbiological properties of dental prostheses and implants and can be used to improve drug delivery through the oral mucosa. This paper reviewed studies from 2015 to 2020 and summarized the potential applications of different types of NPs in the many fields of dentistry.

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Bio-modified TiO2 nanoparticles with Withania somnifera, Eclipta prostrata and Glycyrrhiza glabra for anticancer and antibacterial applications

Cited by 44 publications

References 74 publications

Eco-synthesis and characterization of titanium nanoparticles: Testing its cytotoxicity and antibacterial effects

Eco-synthesis and characterization of titanium nanoparticles: Testing its cytotoxicity and antibacterial effects

The Deposition of a Lectin from <em>Oreochromis niloticus</em> on the Surface of Titanium Dioxide Nanotubes Improve the Cell Adhesion, Proliferation, and Osteogenic Activity of Osteoblast-like Cells

Nanoparticles in Dentistry: A Comprehensive Review

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