Bio-mimicking nano and micro-structured surface fabrication for antibacterial properties in medical implants

Abstract

Orthopaedic and dental implants have become a staple of the medical industry and with an ageing population and growing culture for active lifestyles, this trend is forecast to continue. In accordance with the increased demand for implants, failure rates, particularly those caused by bacterial infection, need to be reduced. The past two decades have led to developments in antibiotics and antibacterial coatings to reduce revision surgery and death rates caused by infection. The limited effectiveness of these approaches has spurred research into nano-textured surfaces, designed to mimic the bactericidal properties of some animal, plant and insect species, and their topographical features. This review discusses the surface structures of cicada, dragonfly and butterfly wings, shark skin, gecko feet, taro and lotus leaves, emphasising the relationship between nano-structures and high surface contact angles on self-cleaning and bactericidal properties. Comparison of these surfaces shows large variations in structure dimension and configuration, indicating that there is no one particular surface structure that exhibits bactericidal behaviour against all types of microorganisms. Recent bio-mimicking fabrication methods are explored, finding hydrothermal synthesis to be the most commonly used technique, due to its environmentally friendly nature and relative simplicity compared to other methods. In addition, current proposed bactericidal mechanisms between bacteria cells and nano-textured surfaces are presented and discussed. These models could be improved by including additional parameters such as biological cell membrane properties, adhesion forces, bacteria dynamics and nano-structure mechanical properties. This paper lastly reviews the mechanical stability and cytotoxicity of micro and nano-structures and materials. While the future of nano-biomaterials is promising, long-term effects of micro and nano-structures in the body must be established before nano-textures can be used on orthopaedic implant surfaces as way of inhibiting bacterial adhesion.

Self-disinfecting surfaces and infection control

“…Sharks have a special scale micropattern, which consist of a rectangular base embedded in the skin with tiny spines on the surface. The ribbed texture of these scales is responsible for the selfcleaning, anti-biofouling, hydrophobic and drag reducing properties of shark skin [81,82]. Such properties have made of sharkskin one of the most mimicked surfaces, not only in research environment but in industrial area too.…”

Mechanical deformations of a liquid crystal elastomer at director angles between 0° and 90°: Deducing an empirical model encompassing anisotropic nonlinearity

“…A current trend in materials science is to develop soft materials, which can mimic the structure, anisotropy, and functionality of materials and tissues found in nature . Developing such materials would enable and increase the functionality of next‐generation technologies such as soft robotics and biomedical devices .…”

Adhesive Force of Flat Indenters With Brush-Structure

“…Textured surfaces are gaining popularity today due to their special physical properties such as nanotextured surface for improvement of water repellent [1] or bactericidal properties of orthopedic implants [2] or tribological properties in hydrodynamic lubrication [3]. Some of these structure designs try to mimic the "mystical" property of nature.…”