“…Such a concept holds the potential for advancing existing schemes of optical detection based on CD, [18,19] since other parameters can come into play, namely, the high Q factor of the DOs, the large nearfield amplification M, and the low mode volume (V) of plasmonic nanoantennas. [20][21][22][23] NH), as fully 3D nanostructures with chiral shape, exhibit a very large optical activity, even under normal incidence conditions. [24] Indeed, in our recent works we described how ordered arrays of 3D NHs can build up a chiral metacrystal, with resulting chiroptical response ruled out by out-ofplane and in-plane lattice parameters, [25] and how they can work as biomolecule sensing systems.…”