Bio-interfacial magnetic resonance imaging of hyperpolarized contrast agents for metabolic flux interrogation in vivo

Jeong, Gijin; Lee, Jee Wook; Gong, Gyeonghyeon; Ko, Hyeji; Choi, Ikjang; Seo, Hyeonglim; Lee, Youngbok; Millward, Niki Zacharias; Bhattacharya, Pratip K.

doi:10.1016/j.jiec.2016.02.002

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Assessment Of Different Therapeutic Interventions1

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2019

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“…Two other hyperpolarized Krebs cycle imaging probes have been developed, 13 C labeled succinic acid [52] and its hydrophobic analog diethyl succinate [53,54,55]. These compounds have been polarized using both the DNP [56] and PHIP [52] polarization methods.…”

Section: Assessment Of Different Therapeutic Interventionsmentioning

confidence: 99%

Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging

Dutta

Salzillo

Pudakalakatti

et al. 2019

Cells

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Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to normal tissue metabolism, linking changes in target metabolism to therapeutic efficacy. Metabolic imaging by Positron Emission Tomography (PET) employing 2-fluoro-deoxy-glucose ([18F]FDG) has been used as a routine diagnostic tool in the clinic. Recently developed hyperpolarized Magnetic Resonance (HP-MR), which radically increases the sensitivity of conventional MRI, has created a renewed interest in functional and metabolic imaging. The successful translation of this technique to the clinic was achieved recently with measurements of 13C-pyruvate metabolism. Here, we review the potential clinical roles for metabolic imaging with hyperpolarized MRI as applied in assessing therapeutic intervention in different cancer systems.

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