Bio-integrative design of the neural tissue-device interface

Shi, Delin; Dhawan, Vaishnavi; Cui, Xiufang

doi:10.1016/j.copbio.2021.10.003

Cited by 23 publications

(22 citation statements)

References 53 publications

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“…Similar to other thin-film neural probes ( 24 – 28 ), the soft mechanics (modulus, ~3 MPa) and thin geometry (~150 μm) of the microfluidic probe enable adaptation to brain micromotion associated with movement, respiration, and blood flow ( 29 , 30 ). These properties can minimize mechanical irritation or tissue damage during in vivo chronic study ( 28 , 31 ). Active, independent fluid perfusion and collection through four microfluidic channels are controlled through the elastic expansion and recovery of the SBS membrane, resulting in push-pull operation.…”

Section: Resultsmentioning

confidence: 99%

Wireless, battery-free push-pull microsystem for membrane-free neurochemical sampling in freely moving animals

Heck

Zhang

et al. 2022

Sci. Adv.

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Extensive studies in both animals and humans have demonstrated that high molecular weight neurochemicals, such as neuropeptides and other polypeptide neurochemicals, play critical roles in various neurological disorders. Despite many attempts, existing methods are constrained by detecting neuropeptide release in small animal models during behavior tasks, which leaves the molecular mechanisms underlying many neurological and psychological disorders unresolved. Here, we report a wireless, programmable push-pull microsystem for membrane-free neurochemical sampling with cellular spatial resolution in freely moving animals. In vitro studies demonstrate the sampling of various neurochemicals with high recovery (>80%). Open-field tests reveal that the device implantation does not affect the natural behavior of mice. The probe successfully captures the pharmacologically evoked release of neuropeptide Y in freely moving mice. This wireless push-pull microsystem creates opportunities for neuroscientists to understand where, when, and how the release of neuropeptides modulates diverse behavioral outputs of the brain.

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Section: Resultsmentioning

confidence: 99%

Wireless, battery-free push-pull microsystem for membrane-free neurochemical sampling in freely moving animals

Heck

Zhang

et al. 2022

Sci. Adv.

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“…An essential requirement for reference electrodes—non-polarizability—rules out many electrode materials used for other applications, like stainless steel, gold, and platinum. Iridium oxide (IrOx) is one promising alternative to Ag/AgCl due to its biocompatibility, and has been used in sensing, stimulation, and recording studies in vivo ( Li et al., 2009 , 2016 ; Shi et al., 2021 ; Zheng et al., 2021 ). Unlike Ag/AgCl, IrOx is polarizable, although much less so than other electrode materials like platinum ( Li et al., 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Accurate and stable chronic in vivo voltammetry enabled by a replaceable subcutaneous reference electrode

2022

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“…Adapted from the study by Shi et al with Creative Commons license. 1 signal-to-noise ratio along with spatial resolution. 88 Strategies involving tissue engineering incorporate an infrastructural material component which can provide the ideal environment for structural regeneration along with the required signaling cues to support the cellular growth.…”

Section: C Tissue Engineeringmentioning

confidence: 99%