Bio-inspired wrinkle microstructures for random lasing governed by surface roughness

Gummaluri, Venkata Siva; Radhakrishnan, Gayathri; Vijayan, C.; Murukeshan, Vadakke Matham

doi:10.1364/ol.417148

Cited by 10 publications

(8 citation statements)

References 29 publications

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“…In real tissue samples, biocompatible fluorescent anticancer drugs and organic dyes could be used to generate random lasing [13,14]. The phantom tissue sample was initially investigated for lasing using a standard random lasing experimental setup [33]. 532 nm second harmonic emission from an Nd:YAG laser (VIBRANT 355 II, OPOTEK Inc., Carlsbad, CA, USA) running at 10 Hz repetition rate and 5 ns pulse duration was used as the excitation source.…”

Section: Phantom Tissue Model Of Tumor Polypmentioning

confidence: 99%

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Random Lasing for Bimodal Imaging and Detection of Tumor

Gayathri,

Suchand Sandeep,

Vijayan

et al. 2023

Biosensors

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The interaction of light with biological tissues is an intriguing area of research that has led to the development of numerous techniques and technologies. The randomness inherent in biological tissues can trap light through multiple scattering events and provide optical feedback to generate random lasing emission. The emerging random lasing signals carry sensitive information about the scattering dynamics of the medium, which can help in identifying abnormalities in tissues, while simultaneously functioning as an illumination source for imaging. The early detection and imaging of tumor regions are crucial for the successful treatment of cancer, which is one of the major causes of mortality worldwide. In this paper, a bimodal spectroscopic and imaging system, capable of identifying and imaging tumor polyps as small as 1 mm2, is proposed and illustrated using a phantom sample for the early diagnosis of tumor growth. The far-field imaging capabilities of the developed system can enable non-contact in vivo inspections. The integration of random lasing principles with sensing and imaging modalities has the potential to provide an efficient, minimally invasive, and cost-effective means of early detection and treatment of various diseases, including cancer.

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Section: Phantom Tissue Model Of Tumor Polypmentioning

confidence: 99%

“…Recent research demonstrated how surface corrugations on polymer substrates affect random lasing [33]. Distinct features were observed in the lasing spectra, threshold, and linewidth characteristics with surface roughness variations.…”

Section: Introductionmentioning

confidence: 99%

Random Lasing for Bimodal Imaging and Detection of Tumor

Gayathri,

Suchand Sandeep,

Vijayan

et al. 2023

Biosensors

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“…The structural confinement of disorder plays a crucial role in random lasing emission 19 . Given its sensitive dependence on surface roughness 20 , random lasing provides a distinctive approach for sensing tumor polyps by inspecting the surface variations associated with tumor progression. The random laser-based diagnostic technique is proposed to complement colonoscopy, particularly for identifying smaller and sessile polyps, utilizing their surface variations as a probing parameter.…”

Section: Introductionmentioning

confidence: 99%

Tumour polyp detection using random lasing

Gayathri,

Suchand Sandeep,

Vijayan

et al. 2024

Biomedical Applications of Light Scattering XIV

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Tumors arise from the uncontrolled growth of cells and can be benign or cancerous. The size of the tumor is one of the key factors in assessing its malignancy potential. Generally, larger tumor polyp tends to have higher risk of developing into a cancer. Smaller polyps often start benign but some of it evolve over time to adenomatous or cancerous and extend to other parts of the body. To mitigate this risk, even smaller polyps are usually removed if found during screening. However, the detection of small polyps, especially flat or sessile types, remains a challenge. Advanced techniques are being developed to identify early-stage tumors by studying biomechanical, biochemical, and morphological changes. Tumor progression alters the viscoelasticity, local refractive index, and surface roughness, increasing tissue disorder both structurally and optically. This disorder can localize light through multiple scattering and can be utilized to provide cavity feedback for lasing emission called 'random lasing'. In this work, we simulate a tumor polyp growth in a phantom tissue impregnated with a gain medium and investigate the resulting random lasing emission. We find that the emission properties such as the intensity, lasing threshold, emission wavelength, and linewidth are all influenced by the presence of the polyp and this technique could precisely identify even polyps of size ~ millimeters. Overall, this research showcases the potential of random lasing to investigate disorder-induced changes for early and sensitive detection of tumor and identification of tissue abnormalities.

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“…Nevertheless, due to the random distribution of the scattered particles in a random laser system, the lasing spectrum is varied and unstable. In order to control the random laser emission, scientists have utilized a variety of materials to design random lasers, including semiconductor [5], liquid crystal [6,7], metal nanostructure [8,9], thin film [10], wrinkled graphene oxides [11], waveguide structure [12,13] and even perovskite single crystal [14].…”

Section: Introductionmentioning

confidence: 99%

Stability-Enhanced Emission Based on Biophotonic Crystals in Liquid Crystal Random Lasers

2022

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A new design of a bio-random laser based on a butterfly wing structure and ITO glass is proposed in this article. Firstly, the butterfly wing structure was integrated in a liquid crystal cell made of ITO glass. The integrated liquid crystal cell was injected with liquid crystal and dye to obtain a bio-random laser. A non-biological random laser was obtained with a capillary glass tube, liquid crystal and dye. The excitation spectra and thresholds were recorded to evaluate the performance of the biological and non-biological random lasers. The results show that the excitation performance stability of the bio-random laser is improved and the number of spikes in the spectra is reduced compared with the non-biological random laser. Finally, the equivalent cavity length of the biological and non-biological random lasers was compared and the optical field distribution inside the butterfly wing structure was analyzed. The data show that the improvement of the excitation performance stability of the bio-random laser is related to the localization of the optical field induced by the photonic crystal structure in the butterfly wing.

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Bio-inspired wrinkle microstructures for random lasing governed by surface roughness

Cited by 10 publications

References 29 publications

Random Lasing for Bimodal Imaging and Detection of Tumor

Random Lasing for Bimodal Imaging and Detection of Tumor

Tumour polyp detection using random lasing

Stability-Enhanced Emission Based on Biophotonic Crystals in Liquid Crystal Random Lasers

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