Bio-inspired uniform flow microfluidic sensor platform for multi-analyte sensing: a simulation-based outflow and injection study

Gharpure, Pradnya; Veeralingam, Sushmitha; Badhulika, Sushmee

doi:10.1007/s10404-021-02484-1

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…The designs which are developed for multi-analyte sensing commonly include serpentine [5,9] and tentacle [10] based structures. These designs have a high degree of complexity to design and fabricate.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Evaluating the efficiency of simple T shaped microfluidic biosensor for multianalyte detection using computational based simulation

Ganesan¹,

Selvaraj²

2022

Preprint

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A combined model for a multi-analyte sensing microfluidic chip based on velocity, pressure, and concentration profiles are currently required for efficient sensing of multiple biomarkers. In this present study, we have simulated the 2D and 3D pressure-driven microfluidic chip with T shaped design – with three outlets each containing an active sensing surface area - and one inlet for an incompressible and Newtonian fluid. using COMSOL and evaluating the velocity, pressure, and concentration profiles. The velocity, pressure, and concentration are compared and studied for the real time analysis. The optimized model shows a uniform laminar flow profile with a high adsorption of the analyte to the active surface with less time and high sensitivity than the other reported simulated designs. The model also prevents the backflow of the analyte to enhance the performance and reliability of the sensor. The profile gradients are studied for a micro-total analysis system (µTAS) based on time-dependent biosensing. To prove the efficiency of adsorption by the ligand in the proposed design, various labels are studied. Thus velocity, pressure, and concentration profiles help in validating the design of the microfluidic biosensor. Furthermore, customized designs can be developed based on the requirement for microfluidic channel-based sensing applications.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Evaluating the efficiency of simple T shaped microfluidic biosensor for multianalyte detection using computational based simulation

Ganesan¹,

Selvaraj²

2022

Preprint

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show abstract

“…2) was designed to cover the entire electrode surface, so that it is completely wetted by the substrate solution with a liquid layer thickness of 100 μm. The addition of dispatchers to fractionate and stabilise the flow distribution 32 over the electrode proved to be efficient. Similarly, the microcolumns prevented the almost 8 mm wide chamber (100 μm height) from collapsing.…”

Section: Development Of the Integrated Systemmentioning

confidence: 99%

A three-dimensional microfluidic flow cell and system integration for improved electrochemical substrate detection in HRP/TMB-based immunoassays

2023

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WITHDRAWN: Evaluating the efficiency of simple T shaped microfluidic biosensor for multianalyte detection using computational based simulation

2022

Preprint

View full text Add to dashboard Cite

show abstract

Bio-inspired uniform flow microfluidic sensor platform for multi-analyte sensing: a simulation-based outflow and injection study

Cited by 3 publications

References 39 publications

WITHDRAWN: Evaluating the efficiency of simple T shaped microfluidic biosensor for multianalyte detection using computational based simulation

WITHDRAWN: Evaluating the efficiency of simple T shaped microfluidic biosensor for multianalyte detection using computational based simulation

A three-dimensional microfluidic flow cell and system integration for improved electrochemical substrate detection in HRP/TMB-based immunoassays

WITHDRAWN: Evaluating the efficiency of simple T shaped microfluidic biosensor for multianalyte detection using computational based simulation

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