Bio-inspired Janus gold nanoclusters with lipid and amino acid functional capping ligands: micro-voltammetry and in situ electron transfer in a biogenic environment

Molecular self-assembly is a topic attracting intense scientific interest. Various strategies have been developed for construction of molecular aggregates with rationally designed properties, geometries, and dimensions that promise to provide solutions to both theoretical and practical problems in areas such as drug delivery, medical diagnostics, and biosensors, to name but a few. In this respect, gold nanoparticles covered with self-assembled monolayers presenting nanoscale surface patterns—typically patched, striped or Janus-like domains—represent an emerging field. These systems are particularly intriguing for use in bio-nanotechnology applications, as presence of such monolayers with three-dimensional (3D) morphology provides nanoparticles with surface-dependent properties that, in turn, affect their biological behavior. Comprehensive understanding of the physicochemical interactions occurring at the interface between these versatile nanomaterials and biological systems is therefore crucial to fully exploit their potential. This review aims to explore the current state of development of such patterned, self-assembled monolayer-protected gold nanoparticles, through step-by-step analysis of their conceptual design, synthetic procedures, predicted and determined surface characteristics, interactions with and performance in biological environments, and experimental and computational methods currently employed for their investigation.

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“…( 2014 ); e Bourone et al. ( 2016 ), Sarangi and Patnaik ( 2014 ), f Guarino et al. ( 2012 ), Liu et al.…”

Section: Characterization Of the Structure Of Mixed Sams On Nanopartimentioning

confidence: 99%

“…These approaches have been used to characterize amphiphilic Janus NPs ranging from 3.5 to 15 nm, using infrared reflection–absorption spectroscopy (IRRAS) (Bourone et al. 2016 ; Sarangi and Patnaik 2014 ).…”

Section: Characterization Of the Structure Of Mixed Sams On Nanopartimentioning

confidence: 99%

Gold nanoparticles with patterned surface monolayers for nanomedicine: current perspectives

et al. 2017

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“…22,23 incidence of the IR beam. 24 Based on these measurements, they were able to show that the probed AuNPs were Janus-like. However, the IRRAS setup used by Patnaik et al is limited to the characterization of Janus AuNPs smaller than approximately 10 nm in diameter, as for bigger AuNPs the reflectivity of the gold core in the mid-infrared range would impede the detection of the bottom ligand.…”

Section: ■ Introductionmentioning

confidence: 94%

Directed Self-Assembly and Infrared Reflection Absorption Spectroscopy Analysis of Amphiphilic and Zwitterionic Janus Gold Nanoparticles

et al. 2016

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Here, we report an approach to use infrared reflection absorption spectroscopy (IRRAS) for the unambiguous proof of the presence as well as the spatial distribution of organic ligands on the Janus gold nanoparticle (AuNP) surface. For this purpose we synthesized amphiphilic and zwitterionic Janus AuNPs and immobilized these on pretreated gold surfaces by directed self-assembly, exploiting hydrophilic/hydrophobic or electrostatic interactions, respectively. Thus, we obtained macroscopic two-dimensional arrays of Janus AuNPs exhibiting a specific orientation. These arrays were investigated by IRRAS, and the obtained spectra revealed only peaks of the ligands facing the IR beam, while the ligands facing the gold substrate were not detected due to reflection of the IR beam on the AuNP cores. Thus, we describe a straightforward spectroscopic procedure to prove the Janus character of zwitterionic and amphiphilic AuNPs in the size range of 10-15 nm.

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“…[16,17] For instance, electrohydrodynamic (EHD) cojetting allows for rapid fabrication of particles with complex architectures. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Compared to conventional electrospraying, EHD cojetting involves extrusion of two or more polymer solutions through a nozzle under a laminar flow regime ( Figure S1, Supporting Information). Upon application of a DC voltage, the droplet becomes distorted and forms a Taylor cone, from which a high-speed jet is produced.…”

Section: Doi: 101002/smtd201800408mentioning

confidence: 99%

“…A number of methods exist for the fabrication of particles with complex architectures which may be used to mimic naturally occurring intricate structures . For instance, electrohydrodynamic (EHD) cojetting allows for rapid fabrication of particles with complex architectures . Compared to conventional electrospraying, EHD cojetting involves extrusion of two or more polymer solutions through a nozzle under a laminar flow regime (Figure S1, Supporting Information).…”

Section: Introductionmentioning

confidence: 99%

Selective Localization of Hierarchically Assembled Particles to Plasma Membranes of Living Cells

et al. 2019

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Particles that preferentially partition to a specific cellular subunit, such as the nucleus, mitochondria, or the cytoskeleton, are of relevance to a number of applications, including drug delivery, genetic manipulation, or self‐assembly. Here, hierarchical assemblies of fully synthetic particles that selectively localize to the plasma membrane of mammalian cells are presented. A multimodal approach is used to create assemblies of polymer‐based carrier particles with amphiphilic gold nanoparticles immobilized on one hemisphere. These assemblies persist in the plasma membrane of cells for several days and undergo rearrangements and clustering, typically considered to be hallmarks of membrane‐bound receptors.

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Bio-inspired Janus gold nanoclusters with lipid and amino acid functional capping ligands: micro-voltammetry and in situ electron transfer in a biogenic environment

Cited by 13 publications

References 73 publications

Gold nanoparticles with patterned surface monolayers for nanomedicine: current perspectives

Gold nanoparticles with patterned surface monolayers for nanomedicine: current perspectives

Directed Self-Assembly and Infrared Reflection Absorption Spectroscopy Analysis of Amphiphilic and Zwitterionic Janus Gold Nanoparticles

Selective Localization of Hierarchically Assembled Particles to Plasma Membranes of Living Cells

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