Bio-inspired calcium silicate–gelatin bone grafts for load-bearing applications

Ding, Shinn-Jyh; Wei, Chung-Kai; Lai, Meng-Heng

doi:10.1039/c1jm11171j

Cited by 22 publications

(25 citation statements)

References 52 publications

(55 reference statements)

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“…A). The hydration reaction of the cement resulted in a CSH gel and calcium hydroxide that may transform into calcite . The lower Si/Ca ratio was in the precursor, the higher the CSH/CaCO 3 and β‐Ca 2 SiO 4 contents were in the cement, which also indicated a greater crystallinity.…”

Section: Resultsmentioning

confidence: 99%

Composition‐dependent protein secretion and integrin level of osteoblastic cell on calcium silicate cements

Shie

Chang

Ding

2013

J Biomedical Materials Res

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The purpose of this study was to investigate the responses of the human osteosarcoma cell line MG63 to calcium silicate cements with different Si/Ca molar ratios and different surface roughness. In particular, the study evaluated integrin subunit levels, phosphor-focal adhesion kinase (pFAK) levels and protein production at the cell attachment stage. The results indicated that the surface roughness (variations within a factor of 10) of the cements did not play a prominent role in cell attachment and proliferation, but the effect of composition was highlighted. Increased pFAK and total integrin levels and promoted cell attachment and cell cycle progression were observed upon an increase in cement Si content. Cement with a higher Si content was beneficial for collagen Type I (COL I) adsorption, COL I secretion, and αlibβ3 subintegrin expression, whereas cement with a higher Ca content increased fibronectin (FN) adsorption, FN secretion, and enhanced αvβ1 subintegrin levels. These results establish composition-dependent differences in integrin binding as a mechanism regulating cellular responses to biomaterial surfaces.

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Section: Resultsmentioning

confidence: 99%

Composition‐dependent protein secretion and integrin level of osteoblastic cell on calcium silicate cements

Shie

Chang

Ding

2013

J Biomedical Materials Res

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“…Calcium silicate-gelatin composites were reported to have fatigue life ranging from 10 3 –10 5 at a 30 MPa load (Ding, Wei et al 2011). Additionally, 13–93 bioactive glass scaffolds made by robotic deposition were reported to have fatigue lives ranging from 10 4 –10 6 at loads from 10–30 MPa (Liu, Rahaman et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Compressive fatigue and fracture toughness behavior of injectable, settable bone cements

Harmata

Uppuganti

Granke

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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Bone grafts used to repair weight-bearing tibial plateau fractures often experience cyclic loading, and there is a need for bone graft substitutes that prevent failure of fixation and subsequent morbidity. However, the specific mechanical properties required for resorbable grafts to optimize structural compatibility with native bone have yet to be established. While quasi-static tests are utilized to assess weight-bearing ability, compressive strength alone is a poor indicator of in vivo performance. In the present study, we investigated the effects of interfacial bonding on material properties under conditions that re-capitulate the cyclic loading associated with weight-bearing fractures. Dynamic compressive fatigue properties of polyurethane (PUR) composites made with either unmodified (U-) or polycaprolactone surface-modified (PCL-) 45S5 bioactive glass (BG) particles were compared to a commercially available calcium sulfate and phosphate-based (CaS/P) bone cement at physiologically relevant stresses (5–30 MPa). Fatigue resistance of PCL-BG/polymer composite was superior to that of U-BG and CaS/P at higher stress levels for each of fatigue failure criteria, related to modulus, creep, and maximum displacement, and was comparable to human trabecular bone. Steady state creep and damage accumulation occurred during the fatigue life of the PCL-BG/PUR and CaS/P cement, whereas creep of U-BG/PUR primarily occurred at a low number of loading cycles. From crack propagation testing, fracture toughness or resistance to crack growth was significantly higher for the PCL-BG composite than for the other materials. Finally, the fatigue and fracture toughness properties were intermediate between those of trabecular and cortical bone. These findings highlight the potential of PCL-BG/polyurethane composites as weight-bearing bone grafts.

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“…The measurement of the porosity was conducted by using a liquid displacement technique (Ding et al 2011b). In this method, ethanol was used as the displacement liquid because water was the setting liquid.…”

Section: Porositymentioning

confidence: 99%

Physicochemical properties of radiopaque dicalcium silicate cement as a root‐end filling material in an acidic environment

Ding

2012

Int Endodontic J

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Bio-inspired calcium silicate–gelatin bone grafts for load-bearing applications

Cited by 22 publications

References 52 publications

Composition‐dependent protein secretion and integrin level of osteoblastic cell on calcium silicate cements

Composition‐dependent protein secretion and integrin level of osteoblastic cell on calcium silicate cements

Compressive fatigue and fracture toughness behavior of injectable, settable bone cements

Physicochemical properties of radiopaque dicalcium silicate cement as a root‐end filling material in an acidic environment

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