Bio-inspired Biomaterials and their Drug Delivery Perspectives - A Review

Villalba‐Rodríguez, Angel M.; Parra‐Saldívar, Roberto; Ahmed, Ishtiaq; Karthik, Kumaragurubaran; Malik, Yashpal Singh; Dhama, Kuldeep; Iqbal, Hafiz M.N.

doi:10.2174/1389200218666170925113132

Cited by 7 publications

(8 citation statements)

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“…Then, the relationship between D1 and D2 can be transformed from Equation (6) to Equation 7: Table 2 shows little difference between D1/D2 of films G, GA, and GC, which means to catch up to the significant variation of D1, D2 should alter at the same rate with D1 of each film, respectively. The reason for causing a significant difference between D1 of films G, GA, and GC was assumed to be the different electronical interaction of the emulsifier composition in previous studies.…”

Section: Two-layer Structure Of Filmmentioning

confidence: 99%

“…Different ingredients of food can permeate the film leading to more kinds of molecular interactions, thus further complicating the microscopic release mechanism of active substances. However, interactions such as swelling led by moisture is sometimes beneficial, which, for instance, acts as a trigger for controlled release [6]. Therefore, more studies are needed to understand the microscopic mechanism of active substance release through bio-based film.…”

Section: Introductionmentioning

confidence: 99%

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Diffusion Mechanism of Cinnamon Essential Oils Release from Calcium Alginate Based Controlled Release Films in Contact with Food Simulating Solvent

Chen

Yao

et al. 2020

Materials

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Calcium alginate based controlled release films with moderate mechanical properties were fabricated in this paper. The diffusion mechanism of these films contacting food simulating solvent (FSS) was explored in some detail. With the increase of glycerol content, the diffusion coefficient (D) values of cinnamon essential oils (CEOs) diffusing to ethanol first increased slowly (0.3–0.6 mL), then vigorously (0.6–0.9 mL), and then mildly (0.9–1.2 mL). The D values of the CEOs diffused to water are all in the order of magnitude of 10−10 cm2/s. The D values of CEOs diffused from films EG3 and EGC1 to aqueous ethanol altered enormously at a small moisture percentage (w = 0.3), then continuously varied vigorously, and at last altered mildly in the range of w = 0.3–1. All the results above indicate that, considering the FSS, the diffusion ability of molecules is jointly determined by the size and distribution of free volume in the system (polymer + diffusive substance + solvents), the intermolecular interaction, and the partition coefficient of the solvents. In addition, several pairs of D values, such as DEG and DGA, are very close to each other, indicating that different kinds of interactions between different groups may have the same effect on the diffusion ability of molecules. The correlation between D1 and D2 indicates that polymeric emulsifier chains also exist in the polymer-rich layer. All the findings and analysis could provide the theoretical basis and data support for further molecular dynamic simulation and could guide the design of controlled release food packaging for food protection.

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Section: Two-layer Structure Of Filmmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diffusion Mechanism of Cinnamon Essential Oils Release from Calcium Alginate Based Controlled Release Films in Contact with Food Simulating Solvent

Chen

Yao

et al. 2020

Materials

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“…However, the main drawback of covalent bonding is the requirement for the treatment of the alloy surface with methacryloxypropyltrimethoxysilane [ 8 ] or bis(ethylene glycol) linkers [ 10 ] so as to enable the subsequent attachment of antibiotics (ATB). In contrast to the low level of efficiency of poly (methyl methacrylate) (PMMA) antibiotic carriers, which have been used in the field of orthopedics for almost 40 years [ 2 , 11 ], biodegradable and resorbable materials enjoy the advantages of the controlled release of antibiotics, broad compatibility with a range of antimicrobial agents, and the dispensing of the need for follow-up surgery for the removal of non-biodegradable carriers [ 12 , 13 , 14 , 15 , 16 , 17 ]. The application of biomaterials in the treatment of implant-associated osteomyelitis was recently comprehensively reviewed by Inzana et al [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Vancomycin-Loaded Collagen/Hydroxyapatite Layers Electrospun on 3D Printed Titanium Implants Prevent Bone Destruction Associated with S. epidermidis Infection and Enhance Osseointegration

et al. 2021

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The aim of the study was to develop an orthopedic implant coating in the form of vancomycin-loaded collagen/hydroxyapatite layers (COLHA+V) that combine the ability to prevent bone infection with the ability to promote enhanced osseointegration. The ability to prevent bone infection was investigated employing a rat model that simulated the clinically relevant implant-related introduction of bacterial contamination to the bone during a surgical procedure using a clinical isolate of Staphylococcus epidermidis. The ability to enhance osseointegration was investigated employing a model of a minipig with terminated growth. Six weeks following implantation, the infected rat femurs treated with the implants without vancomycin (COLHA+S. epidermidis) exhibited the obvious destruction of cortical bone as evinced via a cortical bone porosity of up to 20% greater than that of the infected rat femurs treated with the implants containing vancomycin (COLHA+V+S. epidermidis) (3%) and the non-infected rat femurs (COLHA+V) (2%). The alteration of the bone structure of the infected COLHA+S. epidermidis group was further demonstrated by a 3% decrease in the average Ca/P molar ratio of the bone mineral. Finally, the determination of the concentration of vancomycin released into the blood stream indicated a negligible systemic load. Six months following implantation in the pigs, the quantified ratio of new bone indicated an improvement in osseointegration, with a two-fold bone ingrowth on the COLHA (47%) and COLHA+V (52%) compared to the control implants without a COLHA layer (27%). Therefore, it can be concluded that COLHA+V layers are able to significantly prevent the destruction of bone structure related to bacterial infection with a minimal systemic load and, simultaneously, enhance the rate of osseointegration.

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“…Another important issue in drug delivery is to maintain continuous and sustained release . An ideal case is nearly zero-order constant release, which can only be realized in the so-called single-file diffusion (SFD) condition.…”

Section: Introductionmentioning

confidence: 99%

“…22 Another important issue in drug delivery is to maintain continuous and sustained release. 23 An ideal case is nearly zero-order constant release, which can only be realized in the so-called single-file diffusion (SFD) condition. If it is possible to control the channel/pore size precisely to not allow the passage of two or more drug molecules simultaneously through the membrane because of the physical constriction effect, they are released by SFD instead of Fickian diffusion in the freediffusing condition.…”

Section: ■ Introductionmentioning

confidence: 99%

pH-Controlled Drug Release by Diffusion through Silica Nanochannel Membranes

Zhao

2018

ACS Appl. Mater. Interfaces

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We report in this work the fabrication of a flow-through silica nanochannel membrane (SNM) for controlled drug release applications. The ultrathin SNM consists of parallel nanochannels with a uniform diameter of ∼2.3 nm and a density of 4 × 10 cm, which provide simultaneously high permeability and size selectivity toward small molecules. The track-etched porous polyethylene terephthalate film premodified with silane on its surface was used to support the ultrathin SNM via irreversible covalent bond formation, thus offering mechanical strength, flexibility, and stability to the ultrathin SNM for continuous and long-term use. Alkylamines were subsequently grafted onto the SNM surface to modulate the "on" and "off" state of nanochannels by medium pH for controlled drug release. Thiamphenicol glycinate hydrochloride (TPG), an intestinal drug, was studied as a model to permeate through an ultrathin SNM in both simulated gastric fluid (pH = 1.2) and simulated intestinal fluid (pH = 7.5). The release in the latter case was 178 times faster than that in the former. Moreover, a nearly zero-order constant release of TPG via single-file diffusion was achieved up to 24 h, demonstrating the feasibility of sustained and continuous release of small-molecule drugs in a pH-controlled manner.

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Bio-inspired Biomaterials and their Drug Delivery Perspectives - A Review

Cited by 7 publications

References 0 publications

Diffusion Mechanism of Cinnamon Essential Oils Release from Calcium Alginate Based Controlled Release Films in Contact with Food Simulating Solvent

Diffusion Mechanism of Cinnamon Essential Oils Release from Calcium Alginate Based Controlled Release Films in Contact with Food Simulating Solvent

Vancomycin-Loaded Collagen/Hydroxyapatite Layers Electrospun on 3D Printed Titanium Implants Prevent Bone Destruction Associated with S. epidermidis Infection and Enhance Osseointegration

pH-Controlled Drug Release by Diffusion through Silica Nanochannel Membranes

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