Bio-heterogeneous Cu(0)NC@PHA for n-aryl/alkylation at room temperature

Aza‐Michael Reaction: A Decade Later – Is the Research Over?

“…This phenomenon is easy explained by high abundance of copper in nature and by simplicity of preparation of Cu bearing nanoparticles with wide range of state of oxidation of copper such as Cu(0), Cu(I) and Cu(II). The aza-Michael reactions with various copper nanocatalysts are studied in several [123][124][125][126][127][128] The most rich collection of β-amino esters and nitriles 63 is prepared from primary and secondary aliphatic and aromatic amines has been presented very recently (Scheme 38). [125] Nanocrystalline copper(II) oxide also efficiently catalyzes the conjugate addition of both aliphatic and aromatic amines to acrylonitrile 1 in water under ultrasonic vibration to produce βamino propanenitriles in moderate yields.…”

“…The aza-Michael reactions with various copper nanocatalysts are studied in several [123][124][125][126][127][128] The most rich collection of β-amino esters and nitriles 63 is prepared from primary and secondary aliphatic and aromatic amines has been presented very recently (Scheme 38). [125] Nanocrystalline copper(II) oxide also efficiently catalyzes the conjugate addition of both aliphatic and aromatic amines to acrylonitrile 1 in water under ultrasonic vibration to produce βamino propanenitriles in moderate yields. [123] Magnetite-bearing nanoparticles (MNPs) a type of alternative support or catalyst-supported material, have been explored extensively in aza-Michael reaction for the last ten years.…”

“…This phenomenon is easy explained by high abundance of copper in nature and by simplicity of preparation of Cu bearing nanoparticles with wide range of state of oxidation of copper such as Cu(0), Cu(I) and Cu(II). The aza‐Michael reactions with various copper nanocatalysts are studied in several works [123–128] . The most rich collection of β‐amino esters and nitriles 63 is prepared from primary and secondary aliphatic and aromatic amines has been presented very recently (Scheme 38).…”

“…The most rich collection of β‐amino esters and nitriles 63 is prepared from primary and secondary aliphatic and aromatic amines has been presented very recently (Scheme 38). [125] …”