Bio-guided study of the antinociceptive, anti-inflammatory, and free-radical scavenging capacity of the leaves of Rhus virens Lindh. ex A. Gray and its possible mechanism of antinociception

Vargas-Ruiz, Rodrigo; Montiel-Ruiz, Rosa Mariana; Zamilpa, Alejandro; González-Cortazar, Manasés; Herrera-Ruíz, Maribel; Molina-Cabrera, Jaqueline; Juárez-Aragón, María Cruz; Flores‐Murrieta, Francisco J.

doi:10.1016/j.jep.2022.115756

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…The richness of these extracts in flavonoids explains their effects since they can inhibit the production of hyperalgesia mediators such as those mentioned above and others as nitric oxide and calcium, which interfere with release of neurotransmitters that stimulate pain and inflammation (Zare et al, 2018). Our results are in accordance with those found by Vargas-Ruiz et al, (2022) who confirms that the administration of aqueous, methanolic and hexanolic extracts of Rhus virens prior to the injection of formalin resulted in a decrease of the licking time in both phases of the formalin test.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of Antinociceptive Activity, Antioxidant Properties and Total Phenolic Content of the Ethanolic Extracts of Rhus Pentaphylla Leaves and Fruits From Morocco

2023

THE JAPS

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The aims of study were to investigate the analgesic, antioxidant activities of Rhus pentaphylla ethanolic extracts (leaves and fruits). Three animal models were used to evaluate the possible analgesic effect such as, hot plate, writhing and formalin tests. The antioxidant activity of both extracts were evaluated using DPPH and FRAP tests. Total phenolic compounds, condensed tannins and flavonoids were also estimated. Our findings demonstrates that ethanolic extracts of Rhus pentaphylla possess an analgesic remarkable effect of leaves followed by fruits in all experimental models, in hot plate assay time of latency was increased significantly (p≤0.001) in treated groups at all doses in comparison to the negative control. In writhing test, treated animals by both extracts at all pharmacological doses demonstrates notable reduction (p≤0.001) of writhing numbers. Concerning formalin test, administration of Rhus pentaphylla extracts reduce significantly (p≤0.001) licking time in both phases indicates a possible central and peripheral mechanisms respectively. Moreover, leaves extract possess an important antioxidant capacity (IC50= 47,20 ± 0,23 µg/ml; IC50= 64,10 ± 0,73 µg/ml for DPPH and FRAP assays respectively) than fruits extract (IC= 55,24 ± 0,26 µg/ml; IC50= 75,30 ± 1,01 µg/ml). This last recorded activity due to the amount of total polyphenols in leaves (13,25 ± 0,01 mg GAE/g DW) as compared to the fruits (12,97 ± 0,26 mg GAE/g DW).

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Section: Discussionsupporting

confidence: 90%

Evaluation of Antinociceptive Activity, Antioxidant Properties and Total Phenolic Content of the Ethanolic Extracts of Rhus Pentaphylla Leaves and Fruits From Morocco

2023

THE JAPS

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“…), a blocker of K + ATP channels. The doses and treatment schedules utilized to explore the mechanisms of action were taken from previous reports [23][24][25][26]. After applying the pretreatments and β-caryophyllene oxide, the anti-nociceptive activity was evaluated and compared to that found with β-caryophyllene oxide alone.…”

Section: Evaluation Of the Mechanism Of Action Of β-Caryophyllene Oxidementioning

confidence: 99%

Synergistic Antinociceptive Effect of β-Caryophyllene Oxide in Combination with Paracetamol, and the Corresponding Gastroprotective Activity

Espinosa-Juárez,

Arrieta,

Briones-Aranda

et al. 2024

Biomedicines

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Pain is the most frequent symptom of disease. In treating pain, a lower incidence of adverse effects is found for paracetamol versus other non-steroidal anti-inflammatory drugs. Nevertheless, paracetamol can trigger side effects when taken regularly. Combined therapy is a common way of lowering the dose of a drug and thus of reducing adverse reactions. Since β-caryophyllene oxide (a natural bicyclic sesquiterpene) is known to produce an analgesic effect, this study aimed to determine the anti-nociceptive and gastroprotective activity of administering the combination of paracetamol plus β-caryophyllene oxide to CD1 mice. Anti-nociception was evaluated with the formalin model and gastroprotection with the model of ethanol-induced gastric lesions. According to the isobolographic analysis, the anti-nociceptive interaction of paracetamol and β-caryophyllene oxide was synergistic. Various pain-related pathways were explored for their possible participation in the mechanism of action of the anti-nociceptive effect of β-caryophyllene oxide, finding that NO, opioid receptors, serotonin receptors, and K+ATP channels are not involved. The combined treatment showed gastroprotective activity against ethanol-induced gastric damage. Hence, the synergistic anti-nociceptive effect of combining paracetamol with β-caryophyllene oxide could be advantageous for the management of inflammatory pain, and the gastroprotective activity should help to protect against the adverse effects of chronic use.

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Bio-guided study of the antinociceptive, anti-inflammatory, and free-radical scavenging capacity of the leaves of Rhus virens Lindh. ex A. Gray and its possible mechanism of antinociception

Cited by 2 publications

References 39 publications

Evaluation of Antinociceptive Activity, Antioxidant Properties and Total Phenolic Content of the Ethanolic Extracts of Rhus Pentaphylla Leaves and Fruits From Morocco

Evaluation of Antinociceptive Activity, Antioxidant Properties and Total Phenolic Content of the Ethanolic Extracts of Rhus Pentaphylla Leaves and Fruits From Morocco

Synergistic Antinociceptive Effect of β-Caryophyllene Oxide in Combination with Paracetamol, and the Corresponding Gastroprotective Activity

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