Bio-functionalized zinc oxide nanoparticles: Potential toxicity impact on freshwater fish Cyprinus carpio

Rajkumar, Krishnasamy Sekar; Palaniyappan, Sivagaami; Ramkumar, Arunachalam; Anbazhagan, Murugadas; Veeran, Srinivasan; Sridhar, Arun; Kumar, P. Senthil; Ramasamy, Thirumurugan

doi:10.1016/j.chemosphere.2021.133220

Cited by 31 publications

(9 citation statements)

References 90 publications

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“…In previous research, an association was found between the increase in trace elements and the increase in food intake, but tissue distribution is not the same for all the minerals. For example, the liver and kidneys are normally the tissues where these increases are higher [ 43 , 44 , 45 , 46 ]. These findings are consistent with the results obtained in the present study; in this case, when food intake was increased, Zn tended to be the mineral where tissue deposits increased more, followed by Cu, whereas no significant changes were found in Mn ( Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…In chickens supplemented with zinc sulfate or zinc oxide nanoparticles, no liver increases in the gene expression of SOD, CAT, GST, GPx and NQO1 have been found [ 45 ]. However, it has been reported that exposing fish to Zn oxide nanoparticles increased SOD, CAT, GST and GPx activity [ 46 ]. Other authors found no changes in SOD and GPx after supplementation with Zn, Cu, Se and Mn supplied by subcutaneous injection to dairy cows [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Sánchez-González

Moreno

Aranda

et al. 2022

Biology

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Our aim was to examine whether vanadium (IV) corrects alterations in zinc, copper and manganese homeostasis, observed in streptozotocin-induced hyperglycemic rats, and whether such changes are related to divalent metal transporter 1 (DMT1) mRNA expression, and antioxidant and proinflammatory parameters. Four groups of Wistar rats were examined: control; hyperglycemic (H); hyperglycemic treated with 1 mg V/day (HV); and hyperglycemic treated with 3 mg V/day (HVH). Vanadium was supplied in drinking water as bis(maltolato)oxovanadium(IV) for five weeks. Zinc, copper and manganese were measured in food, excreta, serum and tissues. DMT1 mRNA expression was quantified in the liver. Hyperglycemic rats showed increased Zn and Cu absorption and content in the liver, serum, kidneys and femurs; DMT1 expression also increased (p < 0.05 in all cases). HV rats showed no changes compared to H rats other than decreased DMT1 expression (p < 0.05). In the HVH group, decreased absorption and tissular content of studied elements (p < 0.05 in all cases) and DMT1 expression compared to H (p < 0.05) were observed. Liver zinc, copper and manganese content correlated positively with glutathione peroxidase activity and negatively with catalase activity (p < 0.05 in both cases). In conclusion, treatment with 3 mg V/d reverted the alterations in zinc and copper homeostasis caused by hyperglycemia, possibly facilitated by decreased DMT1 expression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Sánchez-González

Moreno

Aranda

et al. 2022

Biology

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“…Numerous studies link ZnO-NPs’ cytotoxic effects to oxidative stress development and the increase of ROS levels in the cells, which disrupts the cellular redox balance and can seriously harm biological macromolecules and cause genetic instability [ 63 , 64 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

Zinc Oxide Nanoparticles (ZnO-NPs) Suppress Fertility by Activating Autophagy, Apoptosis, and Oxidative Stress in the Developing Oocytes of Female Zebrafish

et al. 2022

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In vertebrates, the core mechanisms that control gametogenesis are largely multiple, complex, successive, and orchestrated by intrinsic and extrinsic factors. However, age, health status, and hormonal activity are important factors for good fertility; other intangible intracellular molecular mechanisms that manage oocyte development are still unclear. The present study was designed to elucidate the ultrastructure changes in the ovary in response to its exposure to zinc oxide nanoparticles (ZnO-NPs) and to explore the role of autophagy and apoptosis during egg maturation and ovulation on the fertility of female zebrafish. In our study, ZnO-NPs could induce cytotoxicity in the maturing oocyte by activating autophagy and apoptosis in a caspase-dependent manner and could induce oxidative stress by generating reactive oxygen species (ROS) that elevated the mutated ovarian tP53 protein. Simultaneously, necroptosis developed, mimicking the features of apoptosis and necrosis. Collectively, ZnO-NPs created a suitable necrotic environment that led to follicular developmental retardation that altered oocyte ovulation and reduced fecundity of female zebrafish.

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“…Other previous studies declared that ZnO-NPs inhibit the hatchability, and normal growth, and induce morphological malformations and neurodevelopmental abnormalities in the zebrafish embryos [ 11 , 12 ] along with hematotoxicity [ 13 ], nephrotoxicity [ 14 ], reproductive toxicity [ 15 ], and immunomodulation [ 16 ] in the adult fishes. In fact, the liver is a key metabolic organ responsible for many vital functions including energy metabolism and detoxification of various environmental pollutants [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Dunaliella salina Microalga Restores the Metabolic Equilibrium and Ameliorates the Hepatic Inflammatory Response Induced by Zinc Oxide Nanoparticles (ZnO-NPs) in Male Zebrafish

Mawed

Centoducati

Farag

et al. 2022

Biology

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Microalgae are rich in bioactive compounds including pigments, proteins, lipids, polyunsaturated fatty acids, carbohydrates, and vitamins. Due to their non-toxic and nutritious characteristics, these are suggested as important food for many aquatic animals. Dunaliella salina is a well-known microalga that accumulates valuable amounts of carotenoids. We investigated whether it could restore the metabolic equilibrium and mitigate the hepatic inflammation induced by zinc oxide nanoparticles (ZnO-NPs) using male zebrafish which were exposed to 1/5th 96 h-LC50 for 4 weeks, followed by dietary supplementation with D. salina at two concentrations (15% and 30%) for 2 weeks. Collectively, ZnO-NPs affected fish appetite, whole body composition, hepatic glycogen and lipid contents, intestinal bacterial and Aeromonas counts, as well as hepatic tumor necrosis factor- α (TNF-α). In addition, the mRNA expression of genes related to gluconeogenesis (pck1, gys2, and g6pc3), lipogenesis (srepf1, acaca, fasn, and cd36), and inflammatory response (tnf-α, tnf-β, nf-kb2) were modulated. D. salina reduced the body burden of zinc residues, restored the fish appetite and normal liver architecture, and mitigated the toxic impacts of ZnO-NPs on whole-body composition, intestinal bacteria, energy metabolism, and hepatic inflammatory markers. Our results revealed that the administration of D. salina might be effective in neutralizing the hepatotoxic effects of ZnO-NPs in the zebrafish model.

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Bio-functionalized zinc oxide nanoparticles: Potential toxicity impact on freshwater fish Cyprinus carpio

Cited by 31 publications

References 90 publications

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Zinc Oxide Nanoparticles (ZnO-NPs) Suppress Fertility by Activating Autophagy, Apoptosis, and Oxidative Stress in the Developing Oocytes of Female Zebrafish

Dunaliella salina Microalga Restores the Metabolic Equilibrium and Ameliorates the Hepatic Inflammatory Response Induced by Zinc Oxide Nanoparticles (ZnO-NPs) in Male Zebrafish

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