Bio-formulated chitosan nanoparticles enhance disease resistance against rice blast by physiomorphic, transcriptional, and microbiome modulation of rice (Oryza sativa L.)

Hafeez, Rahila; Guo, Junning; Ahmed, Temoor; Jiang, Hubiao; Raza, Mubashar; Shahid, Muhammad; Ibrahim, Ezzeldin; Wang, Yanli; Wang, Jiaoyu; Yan, Chengqi; An, Qianli; White, Jason C.; Li, Bin

doi:10.1016/j.carbpol.2024.122023

Cited by 5 publications

(2 citation statements)

References 98 publications

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“…[ 25 , 26 ]. This antimicrobial effect is attributed to multiple mechanisms, such as AgNPs accumulating on the cell walls of pathogens, leading to structural damage, as well as inducing the production of reactive oxygen species (ROS) [ 27 ]. Furthermore, AgNPs have shown promise for enhancing plant growth [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Suppression of Root Rot Fungal Diseases in Common Beans (Phaseolus vulgaris L.) through the Application of Biologically Synthesized Silver Nanoparticles

Ibrahim,

Ahmad,

Abdo

et al. 2024

Nanomaterials

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The biosynthesis of silver nanoparticles (AgNPs) using plant extracts has become a safe replacement for conventional chemical synthesis methods to fight plant pathogens. In this study, the antifungal activity of biosynthesized AgNPs was evaluated both in vitro and under greenhouse conditions against root rot fungi of common beans (Phaseolus vulgaris L.), including Macrophomina phaseolina, Pythium graminicola, Rhizoctonia solani, and Sclerotium rolfsii. Among the eleven biosynthesized AgNPs, those synthesized using Alhagi graecorum plant extract displayed the highest efficacy in suppressing those fungi. The findings showed that using AgNPs made with A. graecorum at a concentration of 100 μg/mL greatly slowed down the growth of mycelium for R. solani, P. graminicola, S. rolfsii, and M. phaseolina by 92.60%, 94.44%, 75.93%, and 79.63%, respectively. Additionally, the minimum inhibitory concentration (75 μg/mL) of AgNPs synthesized by A. graecorum was very effective against all of these fungi, lowering the pre-emergence damping-off, post-emergence damping-off, and disease percent and severity in vitro and greenhouse conditions. Additionally, the treatment with AgNPs led to increased root length, shoot length, fresh weight, dry weight, and vigor index of bean seedlings compared to the control group. The synthesis of nanoparticles using A. graecorum was confirmed using various physicochemical techniques, including UV spectroscopy, Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS) analysis. Collectively, the findings of this study highlight the potential of AgNPs as an effective and environmentally sustainable approach for controlling root rot fungi in beans.

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Section: Introductionmentioning

confidence: 99%

“…AgNPs can be synthesized using various methods, including physical, chemical, and biological approaches [ 27 , 32 , 33 , 34 ]. However, biological methods are considered safer and more environmentally friendly compared to conventional physical and chemical methods [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Suppression of Root Rot Fungal Diseases in Common Beans (Phaseolus vulgaris L.) through the Application of Biologically Synthesized Silver Nanoparticles

Ibrahim,

Ahmad,

Abdo

et al. 2024

Nanomaterials

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Bioengineered carbohydrate polymers for colon‐specific drug release: Current trends and future prospects

Bhirud,

Bhattacharya,

Prajapati

2024

J Biomedical Materials Res

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The worldwide health burden of colorectal cancer is still substantial, and traditional chemotherapeutic drugs sometimes have poor selectivity, which can result in systemic toxicity and unfavorable side effects. For colon‐specific medication delivery, bioengineered carbohydrate polymers have shown promise as carriers. They may enhance treatment effectiveness while minimizing systemic exposure and associated side effects. The unique properties of these manufactured or naturally occurring biopolymers, such as hyaluronic acid, chitosan, alginate, and pectin, enable targeted medicine release. These qualities can be changed to meet the physiological needs of the colon. In the context of colorectal cancer therapy, this article provides a comprehensive overview of current developments and prospective future directions in the field of bioengineered carbohydrate polymer synthesis for colon‐specific drug delivery. We discuss numerous techniques for achieving colon‐targeted drug release, including enzyme‐sensitive polymers, pH‐responsive devices, and microbiota‐activated processes. To increase tumor selectivity and cellular uptake, we also examine the inclusion of active targeting approaches, such as conjugating specific ligands. Furthermore, we discuss the potential of combination treatment strategies, which use the coadministration of numerous therapeutic medications to target multiple pathways implicated in cancer growth and address drug resistance mechanisms. We address recent biomimetic advances that potentially improve the biocompatibility, cellular uptake, and tumor penetration of carbohydrate polymer‐based nanocarriers. These methods involve protein corona engineering and cell membrane coating. Furthermore, we look at the possibility of intelligent and sensitive systems that may adjust their behaviors in response to certain inputs or feedback loops, allowing for precise and regulated drug distribution.

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Integrative transcriptomic and metabolomic analyses reveals the toxicity and mechanistic insights of bioformulated chitosan nanoparticles against Magnaporthe oryzae

Hafeez,

Guo,

Ahmed

et al. 2024

Chemosphere

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Bio-formulated chitosan nanoparticles enhance disease resistance against rice blast by physiomorphic, transcriptional, and microbiome modulation of rice (Oryza sativa L.)

Cited by 5 publications

References 98 publications

Suppression of Root Rot Fungal Diseases in Common Beans (Phaseolus vulgaris L.) through the Application of Biologically Synthesized Silver Nanoparticles

Suppression of Root Rot Fungal Diseases in Common Beans (Phaseolus vulgaris L.) through the Application of Biologically Synthesized Silver Nanoparticles

Bioengineered carbohydrate polymers for colon‐specific drug release: Current trends and future prospects

Integrative transcriptomic and metabolomic analyses reveals the toxicity and mechanistic insights of bioformulated chitosan nanoparticles against Magnaporthe oryzae

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