Bio-fabrication of titanium oxide nanoparticles from Ochradenus arabicus to obliterate biofilms of drug-resistant Staphylococcus aureus and Pseudomonas aeruginosa isolated from diabetic foot infections

Zubair, Mohammad; Husain, Fohad Mabood; Qais, Faizan Abul; Alam, Pravej; Ahmad, Iqbal; Albalawi, Thamer; Ahmad, Naushad; Alam, Manawwer; Baig, Mohammad Hassan; Dong, Jae-June; Fatima, Farha; Alsayed, Badr

doi:10.1007/s13204-020-01630-5

Cited by 18 publications

(18 citation statements)

References 49 publications

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“…The nanoparticles were synthesized leaves extract of O. arabicus that inhibited the biolms of drug-resistant P. aeruginosa and S. aureus isolated from diabetic foot infections of the human subjects with diabetic foot ulcers. 19 Similarly, another study has found that biofabricated porous titanium dioxide nanoparticles synthesized using root extract of Withania somnifera exhibited a broadspectrum antibiolm activity against P. aeruginosa, E. coli, methicillin-resistant S. aureus, S. marcescens, L. monocytogenes, and C. albicans. 46 A study has found that surfaces coated with zinc oxide nanoparticles and ZnO/Ag nanocomposites selectively inhibited the biolms of E. coli, S. aureus, and C. albicans.…”

Section: Microscopic Analysis Of Biolms Inhibition On Glass Surface Usingmentioning

confidence: 96%

“…The major one is variations in phytochemical profile as it is influenced by seasonal or climate variations that may not remain precise enough to obtain reproducible results. 19 Additionally, there is also risk associated that overexploitation of natural resources may cause ecological imbalance of natural bioresources such as microbes and plants.…”

Section: Introductionmentioning

confidence: 99%

“… 20 Moreover, there also some findings on the antibiofilm activity of titanium nanoparticles. 19,21 To the best of our knowledge, very limited reports are available on the broad-spectrum antibiofilm activity of titanium nanoparticles. Most of the previous findings do not considered the impact of nanoparticles on the biofilm's architecture.…”

Section: Introductionmentioning

confidence: 99%

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Effective inhibition and eradication of pathogenic biofilms by titanium dioxide nanoparticles synthesized using Carum copticum extract

et al. 2021

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Section: Microscopic Analysis Of Biolms Inhibition On Glass Surface Usingmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effective inhibition and eradication of pathogenic biofilms by titanium dioxide nanoparticles synthesized using Carum copticum extract

et al. 2021

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“…TiO 2 -NPs biosynthesized using Ochradenus arabicus leaf extract were able to reduce biofilm formation of MDR strains of P. aeruginosa and MRSA isolated from foot ulcers by 22–70% and caused inhibition of exopolymeric substance production even at concentrations lower than MIC via increased ROS generation [ 340 ]. The TiO 2 NPs (3.4–7.6 nm) showed remarkable antibacterial activity against MDR pathogens and their effectiveness decreased in the following order: MRSA > E. coli > P. aeruginosa .…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

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Microbial infections caused by a variety of drug-resistant microorganisms are more common, but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic administration capable of acting against these resistant infectious pathogens. Formulation innovations of existing drugs are gaining prominence, while the application of nanotechnologies is a useful alternative for improving/increasing the effect of existing antimicrobial drugs. Nanomaterials represent one of the possible strategies to address this unfortunate situation. This review aims to summarize the most current results of nanoformulations of antibiotics and antibacterial active nanomaterials. Nanoformulations of antimicrobial peptides, synergistic combinations of antimicrobial-active agents with nitric oxide donors or combinations of small organic molecules or polymers with metals, metal oxides or metalloids are discussed as well. The mechanisms of actions of selected nanoformulations, including systems with magnetic, photothermal or photodynamic effects, are briefly described.

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“…Also, significant damage (51-63 percent) to the preformed biofilms of all tested strains was observed. Moreover, the treatment of bacterial cells with TiO 2 NPs leads to increased ROS production which could be the possible reason for biofilm inhibition (Zubair et al, 2021).…”

Section: Titanium Dioxide Nanoparticlesmentioning

confidence: 99%

Phyto-fabricated Nanoparticles and Their Anti-biofilm Activity: Progress and Current Status

Das

Ghosh

Nayak

2021

Front. Nanotechnol.

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Biofilm is the self-synthesized, mucus-like extracellular polymeric matrix that acts as a key virulence factor in various pathogenic microorganisms, thereby posing a serious threat to human health. It has been estimated that around 80% of hospital-acquired infections are associated with biofilms which are found to be present on both biotic and abiotic surfaces. Antibiotics, the current mainstream treatment strategy for biofilms are often found to be futile in the eradication of these complex structures, and to date, there is no effective therapeutic strategy established against biofilm infections. In this regard, nanotechnology can provide a potential platform for the alleviation of this problem owing to its unique size-dependent properties. Accordingly, various novel strategies are being developed for the synthesis of different types of nanoparticles. Bio-nanotechnology is a division of nanotechnology which is gaining significant attention due to its ability to synthesize nanoparticles of various compositions and sizes using biotic sources. It utilizes the rich biodiversity of various biological components which are biocompatible for the synthesis of nanoparticles. Additionally, the biogenic nanoparticles are eco-friendly, cost-effective, and relatively less toxic when compared to chemically or physically synthesized alternatives. Biogenic synthesis of nanoparticles is a bottom-top methodology in which the nanoparticles are formed due to the presence of biological components (plant extract and microbial enzymes) which act as stabilizing and reducing agents. These biosynthesized nanoparticles exhibit anti-biofilm activity via various mechanisms such as ROS production, inhibiting quorum sensing, inhibiting EPS production, etc. This review will provide an insight into the application of various biogenic sources for nanoparticle synthesis. Furthermore, we have highlighted the potential of phytosynthesized nanoparticles as a promising antibiofilm agent as well as elucidated their antibacterial and antibiofilm mechanism.

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Bio-fabrication of titanium oxide nanoparticles from Ochradenus arabicus to obliterate biofilms of drug-resistant Staphylococcus aureus and Pseudomonas aeruginosa isolated from diabetic foot infections

Cited by 18 publications

References 49 publications

Effective inhibition and eradication of pathogenic biofilms by titanium dioxide nanoparticles synthesized using Carum copticum extract

Effective inhibition and eradication of pathogenic biofilms by titanium dioxide nanoparticles synthesized using Carum copticum extract

Advances in Nanostructures for Antimicrobial Therapy

Phyto-fabricated Nanoparticles and Their Anti-biofilm Activity: Progress and Current Status

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