Bio-conjugated nanoarchitectonics with dual-labeled nanoparticles for a colorimetric and fluorescent dual-mode serological lateral flow immunoassay sensor in detection of SARS-CoV-2 in clinical samples

Kim, Sang Ki; Lee, Jong Uk; Jeon, Myeong Jin; Kim, Soo-Kyung; Hwang, Sang-Hyun; Hong, Min Eui; Sim, Sang Jun

doi:10.1039/d3ra04373h

Cited by 8 publications

(3 citation statements)

References 49 publications

(63 reference statements)

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“…In addition to this, trends such as the development of equipment-free signal readout for semi-quantitative and quantitative analysis have been gaining attention due to its indispensable increased usability and accessibility within paper-based sensors, especially the LFA system [133]. As an example, the conventional qualitative detection output of yes/no has been transformed into measurements based on color distance, counts of area color changes, text readout displays, and other technologies [134][135][136]. In detail, this concise review on the trend of transformation was put together based on a review paper by a group of researchers on papers published from 2020 to 2023 [137].…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in Lateral Flow Assays for Viral Protein Detection with Nanomaterial-Based Optical Sensors

Kim,

Haizan,

Ahn

et al. 2024

Biosensors

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Controlling the progression of contagious diseases is crucial for public health management, emphasizing the importance of early viral infection diagnosis. In response, lateral flow assays (LFAs) have been successfully utilized in point-of-care (POC) testing, emerging as a viable alternative to more traditional diagnostic methods. Recent advancements in virus detection have primarily leveraged methods such as reverse transcription–polymerase chain reaction (RT-PCR), reverse transcription–loop-mediated isothermal amplification (RT-LAMP), and the enzyme-linked immunosorbent assay (ELISA). Despite their proven effectiveness, these conventional techniques are often expensive, require specialized expertise, and consume a significant amount of time. In contrast, LFAs utilize nanomaterial-based optical sensing technologies, including colorimetric, fluorescence, and surface-enhanced Raman scattering (SERS), offering quick, straightforward analyses with minimal training and infrastructure requirements for detecting viral proteins in biological samples. This review describes the composition and mechanism of and recent advancements in LFAs for viral protein detection, categorizing them into colorimetric, fluorescent, and SERS-based techniques. Despite significant progress, developing a simple, stable, highly sensitive, and selective LFA system remains a formidable challenge. Nevertheless, an advanced LFA system promises not only to enhance clinical diagnostics but also to extend its utility to environmental monitoring and beyond, demonstrating its potential to revolutionize both healthcare and environmental safety.

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Section: Discussionmentioning

confidence: 99%

Recent Advances in Lateral Flow Assays for Viral Protein Detection with Nanomaterial-Based Optical Sensors

Kim,

Haizan,

Ahn

et al. 2024

Biosensors

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Section: Rapid Detection Methodsmentioning

confidence: 99%

Rapid assays of SARS-CoV-2 virus and noble biosensors by nanomaterials

Liu,

Li,

Hang

et al. 2024

Nano Convergence

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The COVID-19 outbreak caused by SARS-CoV-2 in late 2019 has spread rapidly across the world to form a global epidemic of respiratory infectious diseases. Increased investigations on diagnostic tools are currently implemented to assist rapid identification of the virus because mass and rapid diagnosis might be the best way to prevent the outbreak of the virus. This critical review discusses the detection principles, fabrication techniques, and applications on the rapid detection of SARS-CoV-2 with three categories: rapid nuclear acid augmentation test, rapid immunoassay test and biosensors. Special efforts were put on enhancement of nanomaterials on biosensors for rapid, sensitive, and low-cost diagnostics of SARS-CoV-2 virus. Future developments are suggested regarding potential candidates in hospitals, clinics and laboratories for control and prevention of large-scale epidemic. Graphical Abstract

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“…In basic fields, nanoarchitectonics can be applied to material synthesis [135][136][137][138][139][140][141], microstructure control [142][143][144][145][146][147][148][149], the elucidation of physical phenomena [150][151][152][153][154][155], and basic life science research [156][157][158][159][160][161]. In the applicationoriented fields, there are reports of applications in catalysis [162][163][164][165][166][167], sensors [168][169][170][171][172], devices [173][174][175][176][177][178], energy generation [179][180][181][182]…”

Section: Introductionmentioning

confidence: 99%

Confined Space Nanoarchitectonics for Dynamic Functions and Molecular Machines

Ariga

2024

Micromachines

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Nanotechnology has advanced the techniques for elucidating phenomena at the atomic, molecular, and nano-level. As a post nanotechnology concept, nanoarchitectonics has emerged to create functional materials from unit structures. Consider the material function when nanoarchitectonics enables the design of materials whose internal structure is controlled at the nanometer level. Material function is determined by two elements. These are the functional unit that forms the core of the function and the environment (matrix) that surrounds it. This review paper discusses the nanoarchitectonics of confined space, which is a field for controlling functional materials and molecular machines. The first few sections introduce some of the various dynamic functions in confined spaces, considering molecular space, materials space, and biospace. In the latter two sections, examples of research on the behavior of molecular machines, such as molecular motors, in confined spaces are discussed. In particular, surface space and internal nanospace are taken up as typical examples of confined space. What these examples show is that not only the central functional unit, but also the surrounding spatial configuration is necessary for higher functional expression. Nanoarchitectonics will play important roles in the architecture of such a total system.

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Bio-conjugated nanoarchitectonics with dual-labeled nanoparticles for a colorimetric and fluorescent dual-mode serological lateral flow immunoassay sensor in detection of SARS-CoV-2 in clinical samples

Abstract: A colorimetric-fluorescent dual-mode lateral flow immunoassay sensor incorporating metal-enhanced fluorescence (MEF) for the rapid and sensitive serological detection of SARS-CoV-2 IgG was developed.

Cited by 8 publications

References 49 publications

Recent Advances in Lateral Flow Assays for Viral Protein Detection with Nanomaterial-Based Optical Sensors

Recent Advances in Lateral Flow Assays for Viral Protein Detection with Nanomaterial-Based Optical Sensors

Rapid assays of SARS-CoV-2 virus and noble biosensors by nanomaterials

Confined Space Nanoarchitectonics for Dynamic Functions and Molecular Machines

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