“…This involves the need for the development of low-cost but highly efficient photo-bioreactors, cultivation and harvesting methods, including inexpensive technologies for concentration of dilute microalgae suspensions at harvest. Some promising approaches for cost reduction include the combination of cultivation with wastewater treatment for nutrient supply [115,116], additional use of aquatic biomass for extraction of high-value compounds prior to biogas production [106,115,117], or the integration with advanced cultivation systems such as integrated multi-trophic aquaculture [109]. Further research is necessary to improve the methane production potential and anaerobic conversion of aquatic biomass through selection of appropriate species and optimization of cultivation conditions for high gas yields, and the development of strategies to increase process stability and to avoid inhibition which may be caused for instance, by high protein, lipid, sulphur, polyphenol, halogen, or saline concentrations in some algae or aquatic plants [115,118].…”