Bio-Based Polymers for 3D Printing of Bioscaffolds

Yang, Elisa; Miao, Shida; Zhong, Jing; Zhang, Zhiyong; Mills, David K.; Zhang, Lijie Grace

doi:10.1080/15583724.2018.1484761

Cited by 82 publications

(46 citation statements)

References 125 publications

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“…As the PVA filament is unwound from a coil and fed through the FDM extrusion nozzle, it melts and is extruded onto a base or onto previously printed layers [24, 30]. The high-temperature PVA solidifies immediately due to the temperature difference between the nozzle (190 °C) and the room (23 °C), as well as the cooling effect from the fan.…”

Section: Resultsmentioning

confidence: 99%

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4D anisotropic skeletal muscle tissue constructs fabricated by staircase effect strategy

et al. 2019

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Like the morphology of native tissue fiber arrangement (such as skeletal muscle), unidirectional anisotropic scaffolds are highly desired as a means to guide cell behavior in anisotropic tissue engineering. In contrast, contour-like staircases exhibit directional topographical cues and are judged as an inevitable defect of fused deposition modeling (FDM). In this study, we will translate this staircase defect into an effective bioengineering strategy by integrating FDM with surface coating technique (FCT) to investigate the effect of topographical cues on regulating behaviors of human mesenchymal stem cells (hMSCs) toward skeletal muscle tissues. This integrated approach serves to fabricate shape-specific, multiple dimensional, anisotropic scaffolds using different biomaterials. 2D anisotropic scaffolds, first demonstrated with different polycaprolactone concentrations herein, efficiently direct hMSC alignment, especially when the scaffold is immobilized on a support ring. By surface coating the polymer solution inside FDM-printed sacrificial structures, 3D anisotropic scaffolds with thin wall features are developed and used to regulate seeded hMSCs through a self-established rotating bioreactor. Using layer-by-layer coating, along with a shape memory polymer, smart constructs exhibiting shape fix and recovery processes are prepared, bringing this study into the realm of 4D printing. Immunofluorescence staining and real-time quantitative polymerase chain reaction analysis confirm that the topographical cues created via FCT significantly enhance the expression of myogenic genes, including myoblast differentiation protein-1, desmin, and myosin heavy chain-2. We conclude that there are broad application potentials for this FCT strategy in tissue engineering as many tissues and organs, including skeletal muscle, possess highly organized and anisotropic extracellular matrix components.

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Section: Resultsmentioning

confidence: 99%

“…Fused deposition modeling (FDM) is a sophisticated additive manufacturing technique for fabricating biomedical scaffolds with controlled pore size, morphology, and interconnectivity [23, 24]. Due to the additive nature of this printing process, the thickness of each layer determines the resolution of the printed scaffolds.…”

Section: Introductionmentioning

confidence: 99%

4D anisotropic skeletal muscle tissue constructs fabricated by staircase effect strategy

et al. 2019

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“…Over the past decade, renewable materials have attracted a great deal of attention from researchers as substitutes for petroleum-derived materials. Since scientists and industry developed and optimized the methods of extraction, purification, and modification of renewable raw materials, these materials became increasingly accessible and easier applicable in optical 3D printing [160]. Tabletop 3D SLA/DLP printers were the first printers to be used to make 3D objects from biobased materials.…”

Section: Renewablesmentioning

confidence: 99%

Photopolymerization Mechanisms at a Spatio-temporally Ultra-confined Light

Skliutas¹,

Lebedevaite²,

Kabouraki³

et al. 2020

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Ultrafast laser 3D lithography based on non-linear light-matter interactions, widely known as multi-photon lithography (MPL), offers unrivaled precision rapid prototyping and flexible additive manufacturing options. 3D printing equipment based on MPL are already commercially available, yet there is still no comprehensive understanding of factors determining spatial resolution, accuracy, fabrication throughput, repeatability, and standardized metrology methods for the accurate characterization of the produced 3D objects and their functionalities. The photoexcitation mechanisms, spatial-control or photo-modified volumes, and the variety of processable materials are topics actively investigated. The complexity of the research field is underlined by limited understanding and fragmented knowledge of light-excitation and material response. Research to date has only provided case-specific findings on photoexcitation, chemical modification, and material characterization of the experimental data. In this review, we aim to provide a consistent and comprehensive summary of the existing literature on photopolymerization mechanisms under highly confined spatial and temporal conditions, where, besides the excitation and cross-linking, parameters such as diffusion, temperature accumulation, and the finite amount of monomer molecules start to become of critical importance. Key parameters such as, photoexcitation, polymerization kinetics, and the properties of the additively manufactured materials at the nanoscale in 3D are examined, whereas, the perspectives for future research and as well as emerging applications are outlined.

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“…On the one hand, biodegradable polymers are those susceptible to degradation by biological activity, with the degradation accompanied by a lowering of its molar mass [10]. In contrast, the "bio-based" adjective does not refer to the properties of the polymers, but to the raw material from which they are obtained, being the bio-based polymers derived from renewable resources, including plants, bacteria or algae, among others [11].…”

Section: Bio-based Polymersmentioning

confidence: 99%

Antibacterial Bio-Based Polymers for Cranio-Maxillofacial Regeneration Applications

Martín-del-Campo¹,

Fernadez-Villa²,

Cabrera-Rueda³

et al. 2020

Preprint

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Cranio-maxillofacial structure is a region of particular interest in the field of regenerative medicine due to both its anatomical complexity and the numerous abnormalities affecting this area. However, this anatomical complexity is what makes possible the coexistence of different microbial ecosystems in the oral cavity and the maxillofacial region, contributing to the increased risk of bacterial infections. In this regard, different materials have been used for their application in this field. These materials can be obtained from natural and renewable feedstocks or by synthetic routes with desired mechanical properties, biocompatibility and antimicrobial activity. Hence, in this review, we have focused on bio-based polymers, which by their own nature, by chemical modifications of their structure, or by their combination with other elements, provide a useful antibacterial activity as well as the suitable conditions for cranio-maxillofacial tissue regeneration. This approach has not been reviewed previously, and we have specifically arranged the content of this article according to the resulting material and its corresponding application, reviewing guided bone regeneration membranes; bone cements; and devices and scaffolds for both soft and hard maxillofacial tissue regeneration, including hybrid scaffolds, dental implants, hydrogels and composites.

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Bio-Based Polymers for 3D Printing of Bioscaffolds

Cited by 82 publications

References 125 publications

4D anisotropic skeletal muscle tissue constructs fabricated by staircase effect strategy

4D anisotropic skeletal muscle tissue constructs fabricated by staircase effect strategy

Photopolymerization Mechanisms at a Spatio-temporally Ultra-confined Light

Antibacterial Bio-Based Polymers for Cranio-Maxillofacial Regeneration Applications

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