Bio-based nanomaterials for cancer therapy

Li, Yonglu; Zheng, Xiaodong; Chu, Qiang

doi:10.1016/j.nantod.2021.101134

Cited by 65 publications

(46 citation statements)

References 183 publications

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“…Much progress has been made to achieve specific delivery goals regarding selectivity, bioavailability, and guided transport and targeting [44][45][46]. For instance, carbon-based nanomaterials such as graphene oxide, reduced graphene oxide, graphene quantum dots, graphene nanoribbons, silica-based nanocarriers, and inorganic nanoparticles [42,43,47,48] have been used to infiltrate tumors with the aid of cell-penetrating agents, and due to enhanced permeation and retention (EPR) mechanisms, they remain inside them for a more extended period [49][50][51].…”

Section: Introductionmentioning

confidence: 99%

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

et al. 2021

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Nutraceutical formulations based on probiotic microorganisms have gained significant attention over the past decade due to their beneficial properties on human health. Yeasts offer some advantages over other probiotic organisms, such as immunomodulatory properties, anticancer effects and effective suppression of pathogens. However, one of the main challenges for their oral administration is ensuring that cell viability remains high enough for a sustained therapeutic effect while avoiding possible substrate inhibition issues as they transit through the gastrointestinal (GI) tract. Here, we propose addressing these issues using a probiotic yeast encapsulation strategy, Kluyveromyces lactis, based on gelatin hydrogels doubly cross-linked with graphene oxide (GO) and glutaraldehyde to form highly resistant nanocomposite encapsulates. GO was selected here as a reinforcement agent due to its unique properties, including superior solubility and dispersibility in water and other solvents, high biocompatibility, antimicrobial activity, and response to electrical fields in its reduced form. Finally, GO has been reported to enhance the mechanical properties of several materials, including natural and synthetic polymers and ceramics. The synthesized GO-gelatin nanocomposite hydrogels were characterized in morphological, swelling, mechanical, thermal, and rheological properties and their ability to maintain probiotic cell viability. The obtained nanocomposites exhibited larger pore sizes for successful cell entrapment and proliferation, tunable degradation rates, pH-dependent swelling ratio, and higher mechanical stability and integrity in simulated GI media and during bioreactor operation. These results encourage us to consider the application of the obtained nanocomposites to not only formulate high-performance nutraceuticals but to extend it to tissue engineering, bioadhesives, smart coatings, controlled release systems, and bioproduction of highly added value metabolites.

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Section: Introductionmentioning

confidence: 99%

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

et al. 2021

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“…ere have been attempts to synthesise these nanomaterials from biomass for safer reactions. Nanocarriers can be used to encapsulate and protect nucleic acid which has anticancer properties [266].…”

Section: Nanocatalysts In Fine Chemical Synthesismentioning

confidence: 99%

Complex Nanomaterials in Catalysis for Chemically Significant Applications: From Synthesis and Hydrocarbon Processing to Renewable Energy Applications

Chadha

Selvaraj

Ashokan

et al. 2022

Advances in Materials Science and Engineering

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The world is rapidly changing, the resources are getting depleted, and the demand for newer technologies and products is increasing. To keep up with these new advances, highly efficient catalytic routes need to be taken to be sustainable and ensure a drawn-out existence of resources for future generations. Catalysis turns out to be a significantly important field of application when it comes to the era of nanoscience, where all devices and technologies are becoming smaller and smaller in size with improved properties. When deeming the usability of a catalyst, it is of paramount importance to have a good understanding of their properties and their synergistic effect on the other reagents in the reaction. Over the last decade, the field of nanocatalysis has grown rapidly, both in homogeneous and heterogeneous catalysis. Given that nanoparticles have a high surface-to-volume ratio when compared to bulk materials, they are appealing as catalysts. Catalysts accelerate and boost thousands of different chemical reactions on a daily basis, forming the foundation of the multibillion-dollar chemical industry worldwide, a pathway leading to green chemistry, and a novel, yet crucial, environmental protection technology. As a result, in this review, the use of nanocatalysts and the application of their special features in the renewable energy, hydrocarbon processing, and fine chemical synthesis sector was explored. A detailed explanation of the working mechanism of these nanocatalysts, starting from how they are synthesized to the effect of modification of their surface, has been put together. We have tried to collect all the current progresses in these three sectors to the best of our abilities. Furthermore, it is anticipated that this paper would be useful for future researchers and academicians wishing to contribute toward this subject of interest.

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“…[37] However, a certain degree of toxicity is reported for many of these materials. [38] As an example, due to the hydrophobic nature of carbon nanotubes, not only the solubility in aqueous media is limited, but also toxic aggregates might be formed, for which reason reducing the toxicity is a central focus in the development of these materials. [39] DNs on the contrary are well suited for the development of robust drug delivery systems.…”

Section: Advantages and Limitations Of Employing Dnsmentioning

confidence: 99%

“…[41] Both organic and inorganic nanomaterials can be surface-modified or equipped with an abundance of functional groups in a rather straightforward manner. [38] Nevertheless, the key advantages of DNA-based particles are their high programmability and superior addressability. In other words, their precise shape, the placement and number of functional units, and their predefined functions can all be controlled.…”

Section: Advantages and Limitations Of Employing Dnsmentioning

confidence: 99%

Prospective Cancer Therapies Using Stimuli‐Responsive DNA Nanostructures

Seitz

Ahmed

Nurmi

et al. 2021

Macromolecular Bioscience

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Nanostructures based on DNA self-assembly present an innovative way to address the increasing need for target-specific delivery of therapeutic molecules. Currently, most of the chemotherapeutics being used in clinical practice have undesired and exceedingly high off-target toxicity. This is a challenge in particular for small molecules, and hence, developing robust and effective methods to lower these side effects and enhance the antitumor activity is of paramount importance. Prospectively, these issues could be tackled with the help of DNA nanotechnology, which provides a route for the fabrication of custom, biocompatible, and multimodal structures, which can, to some extent, resist nuclease degradation and survive in the cellular environment. Similar to widely employed liposomal products, the DNA nanostructures (DNs) are loaded with selected drugs, and then by employing a specific stimulus, the payload can be released at its target region. This review explores several strategies and triggers to achieve targeted delivery of DNs. Notably, different modalities are explained through which DNs can interact with their respective targets as well as how structural changes triggered by external stimuli can be used to achieve the display or release of the cargo. Furthermore, the prospects and challenges of this technology are highlighted.

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Bio-based nanomaterials for cancer therapy

Cited by 65 publications

References 183 publications

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

Complex Nanomaterials in Catalysis for Chemically Significant Applications: From Synthesis and Hydrocarbon Processing to Renewable Energy Applications

Prospective Cancer Therapies Using Stimuli‐Responsive DNA Nanostructures

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