Bio-Barcodes Based on Oligonucleotide-Modified Nanoparticles

Nam, Jwa‐Min; Park, So‐Jung; Mirkin, Chad A.

doi:10.1021/ja0178766

Cited by 263 publications

(169 citation statements)

References 15 publications

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“…Ag, Pt, Au and Pd), silver (Ag) is the metal of abundance for prospective applications in the field of biological systems, living organisms and medicine. Due to their elite properties, AgNPs appear to have quite a lot of applications, such as catalysts in chemical reactions [14,15] , electrical batteries and in spectrally discriminative coatings for absorption of solar energy [16,17] as optical elements, pharmaceutics and in chemical sensing and biosensing [18][19][20] .…”

Section: Research Papermentioning

confidence: 99%

Green Synthesis and Characterization of Silver Nanoparticles from Crocus Mathewii; A Disremembered Turkish Flowering Plant

Yildiztekin¹,

Nadeem²,

Yildiztekin³

et al. 2017

pharmaceutical-sciences

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Mahmut, et al.: Characterization of Silver Nanoparticles from Crocus mathewiiThis study reports the first ever chemical study on Crocus mathewii, a Turkish endemic and forgotten flowering plant. Silver nanoparticles were green synthesized from one mmol×l -1 silver nitrate extract of C. mathewii. The water-suspended silver nanoparticles showed a peak at 423 nm in UV/Vis spectrophotometer that suggested smaller particle size due to its less surface plasmon resonance. Transmission electron microscopy analysis also proved excellent polydispersity of quasi-spherical particle size distribution with average particles of 7.5 nm (2.5-25 nm). The presence of silver in the nanoparticles was analyzed by X-ray diffraction, while Fourier transform infrared spectroscopy analysis showed the presence of various -OH and -NH containing organics. The results proved that the crude extract of C. mathewii can be used for green synthesis of silver nanoparticles in future for medicinal uses.

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Section: Research Papermentioning

confidence: 99%

Green Synthesis and Characterization of Silver Nanoparticles from Crocus Mathewii; A Disremembered Turkish Flowering Plant

Yildiztekin¹,

Nadeem²,

Yildiztekin³

et al. 2017

pharmaceutical-sciences

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“…The benefits of using encoded particles rather than fluorescent tags include improved chemical and photostability and, because more tags are available, more flexibility. Mirkin and colleagues used six Raman-tagged microparticles to perform multiplexed detection of oligonucleotide targets (16,41). The same concept is universally applicable wherever conventional probes are used as labels, such as sandwich immunoassays, single-nucleotide polymorphism genotyping, and tissue labeling (42,43).…”

Section: Multiplexed Bioapplicationsmentioning

confidence: 99%

Peer Reviewed: Barcoding the Microworld

Finkel¹,

Lou²,

Wang³

et al. 2004

Anal. Chem.

129

117

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arcodes are a part of our everyday life. You see them in the grocery store, on letters from the post office, and on DVDs you check out from the video store. Fast, simple, and accurate, barcoding has become the most popular data-entry method to track the ever-exploding amount of information in the macroscopic world in the past 15 years. In the meantime, an increasing demand for tracking smaller items and for direct monitoring of individual chemical interactions has driven the exploration for novel methods of barcoding at much smaller scales (1-4). Successful demonstrations of micro-or nano-sized barcodes in molecular interaction studies (4, 5), combinatorial screening (6), and convert tracking (7 ) have opened up new opportunities for research. This article will introduce recent developments in the field of encoded micro-or nano-sized freestanding particles and various applications. Detailed discussions of other encoding methods, such as molecular tags (8, 9) and non-particle-based platforms (10,11), are beyond the scope of our discussion. Readers who are interested in gaining an in-depth understanding of the field are referred to more comprehensive review papers.A conventional macroscopic barcode is a series of vertical lines ("the bars") and spaces of different widths. Various combinations of bars and spaces represent different characters incorporated in the code. Theoretically, varying the widths, sequential order, and total number of bars and spaces in the barcode can generate an unlimited number of codes. To achieve similar coding capacity at the nanoscale, the right elements to make up the codes (i.e., the bars and spaces) must first be identified. Two criteria are often used in the search for proper elements with distinctive attributes: They must be mixable at

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“…AuNPs have also been studied as a colorimetric nano-particle sensor for a simple assay of bio-related molecules [12][13][14][15][16][17][18][19] and other analytes, [20][21][22] since they possess unique colorimetric properties that arise from their surface plasmon resonance. [23][24][25][26][27][28] The colorimetric property of AuNPs depends on their morphology in a solution.…”

Section: Introductionmentioning

confidence: 99%

Colorimetric Assay of Aminopeptidase N Activity Based on Inhibition of the Disassembly of Gold Nano-composites Conjugated with a Thermo-responsive Copolymer

2009

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A colorimetric change of gold nano-composites conjugated with a thermo-responsive copolymer has been applied to a colorimetric assay to quantify the activity of aminopeptidase N (APN). Heating a solution of assembled gold nanocomposites provokes the gold nano-composites to disassemble, leading to a colorimetric change in the solution from bluepurple to red. The disassembly is inhibited by cysteine, but not by cysteinylglycine, thus allowing us to monitor the progress of an enzymatic decomposition of cysteinylglycine into cysteine and glycine with APN. The activity of APN is estimated through a colorimetric change in a solution of gold nano-composites from blue-purple to red, after being heated (98˚C for 30 min), followed by being cooled. A good relationship between the a* value in L*a*b* color coordinates, which quantified the color of the solution, and the activity of APN was obtained in 3 h of the incubation time, indicating the potential of a colorimetric assay of APN activity.

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Bio-Barcodes Based on Oligonucleotide-Modified Nanoparticles

Cited by 263 publications

References 15 publications

Green Synthesis and Characterization of Silver Nanoparticles from Crocus Mathewii; A Disremembered Turkish Flowering Plant

Green Synthesis and Characterization of Silver Nanoparticles from Crocus Mathewii; A Disremembered Turkish Flowering Plant

Peer Reviewed: Barcoding the Microworld

Colorimetric Assay of Aminopeptidase N Activity Based on Inhibition of the Disassembly of Gold Nano-composites Conjugated with a Thermo-responsive Copolymer

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