Bio-antimutagenic activities of vitamin B6 in E. coli and mouse peripheral blood cells

Shimoi, Kayoko; Akaiwa, E.; Mori, Noriko; Sano, Mitsuaki; Nakamura, Yoshiyuki; Tomita, Isao

doi:10.1016/0027-5107(92)90188-8

Cited by 15 publications

(5 citation statements)

References 18 publications

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“…Oral administration of vitamin B6 resulted in a protective effect against chromium-induced oxidative stress in rat liver [41]. In addition, this vitamin has been demonstrated to possess antimutagenic [42] and anticarcinogenic [43,44] properties. Therefore, it is arguable that the addition of vitamin B6 contributed to the chemopreventive action of Lcystine.…”

Section: Discussionmentioning

confidence: 97%

Chemoprevention of smoke-induced alopecia in mice by oral administration of l-cystine and vitamin B6

D’Agostini

Fiallo

Pennisi

et al. 2007

Journal of Dermatological Science

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Section: Discussionmentioning

confidence: 97%

Chemoprevention of smoke-induced alopecia in mice by oral administration of l-cystine and vitamin B6

D’Agostini

Fiallo

Pennisi

et al. 2007

Journal of Dermatological Science

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“…Of the nutrients examined, folate seemed to have the strongest effect, although other nutrients such as B6 and lutein were also important contributors. The effect of B6, although not independent of that of folate, is noteworthy as B6 (pyridoxine) has been shown to promote DNA excision repair, decreasing levels of unrepaired damaged DNA (18). Higher plasma levels of B6 are associated with a decreased risk for development of lung (19) and breast cancer (20).…”

Section: Discussionmentioning

confidence: 99%

Fruit and Vegetable Intake during Pregnancy and Risk for Development of Sporadic Retinoblastoma

Orjuela

Titievsky

Liu

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Objective: Little is known about the causes of sporadic (noninherited) retinoblastoma. Rates seem to be somewhat higher among poorer populations in Mexico. Fruits and vegetables are important sources of carotenoids and folate. We examined whether decreased gestational maternal intake of fruits and vegetables may contribute to development of sporadic retinoblastoma. Methods: At the Instituto Nacional de Pediatria in Mexico City, we conducted a hospital-based case-control study to evaluate prenatal maternal diet. We examined dietary intake of fruits and vegetables of mothers of 101 children with retinoblastoma and 172 control children using a dietary recall questionnaire and published food nutrient content tables. Results: The reported number of mean daily servings of fruits and vegetables was lower among case mothers when compared with control mothers [vegetables: 2.28 in controls, 1.75 in cases (P < 0.01); fruits: 2.13 in controls, 1.59 in cases (P = 0.07)]. Mean daily maternal folate intake from both vegetables and fruits was higher in controls (103 Mg) than in cases (48 Mg; P < 0.05). Risk for having a child with retinoblastoma was increased for mothers consuming fewer than 2 daily servings of vegetables [odds ratios (OR), 3.4; 95% confidence interval (95% CI), 2.0-6.0] or with a low intake of folate (OR, 3.9; 95% CI, 2.1, 7.3), or lutein/zeaxanthin (OR, 2.6; 95% CI, 1.5-4.6) derived from fruits and vegetables. Conclusions: Decreased intake of vegetables and fruits during pregnancy and the consequent decreased intake of nutrients such as folate and lutein/zeaxanthin, necessary for DNA methylation, synthesis, and retinal function, may increase risk for having a child with sporadic retinoblastoma. (Cancer Epidemiol Biomarkers Prev 2005;14(6):1433 -40)

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“…Thereby the antimutagenesis of 2,4-nonadienal may depend on the UV excision repair system. One hypothesis that has been described is that the bioantimutagens act by extending G 1 allowing DNA repair to go on longer to remove potential mutagenic lesions, hence lower mutation frequency (Shimoi et al, 1992). However, no delay on the cell growth was observed in the presence of 2,4nonadienal in E. coli B/r WP2.…”

Section: Discussionmentioning

confidence: 99%

“…Fewer bioantimutagens than desmutagens have been found from food so far. It has reported that some food ingredients such as cinnamaldehyde (Ohta et al, 1983a), coumarin (Ohta et al, 1983b), tannic acid (Shimoi et al, 1985), catechins (Shimoi et al, 1986;Matsuo et al, 1993), vitamin B 6 (Shimoi et al, 1992), and S-methyl methanethiosulfonate (MMTS) (Nakamura et al, 1996) show bioantimutagenicity in Escherichia coli B/r WP2. Besides researchers have tended to identify only the strongest or a stronger bioantimutagen in food, bioantimutagenicity was tested by each substance alone.…”

Section: Introductionmentioning

confidence: 99%

2,4-Nonadienal and Benzaldehyde Bioantimutagens in Fushimi Sweet Pepper (Fushimi-Togarashi)

Nakamura

Suganuma

Matsuo

et al. 1999

J. Agric. Food Chem.

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Fushimi sweet pepper, "Fushimi-togarashi", is one of the "Kyo-yasai", traditional vegetables, in Kyoto, Japan. The chloroform fraction of Fushimi sweet pepper showed bioantimutagenicity on UV induced mutation in Escherichia coli B/r WP2. The bioantimutagen was purified with silica gel chromatography and identified as 2, 4-nonadienal (ID(50) = 20 microg/plate) on the basis of GC retention time and EI-MS spectrum of authentic 2,4-nonadienal. The sweet pepper also contained a known bioantimutagen, benzaldehyde (ID(50) = 2 mg/plate). Additive bioantimutagenicity was also observed by 2, 4-nonadienal with benzaldehyde. 2,4-Nonadienal did not show bioantimutagenicity in an UV excision repair deficient strain, E. coli B/r WP2s uvrA(-)(). Furthermore no delay of the first cell division after UV irradiation was observed in E. coli B/r WP2. These results indicate that the bioantimutagenic activity of 2, 4-nonadienal on UV mutagenesis might depend on the excision repair system in E. coli B/r WP2.

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Bio-antimutagenic activities of vitamin B6 in E. coli and mouse peripheral blood cells

Cited by 15 publications

References 18 publications

Chemoprevention of smoke-induced alopecia in mice by oral administration of l-cystine and vitamin B6

Chemoprevention of smoke-induced alopecia in mice by oral administration of l-cystine and vitamin B6

Fruit and Vegetable Intake during Pregnancy and Risk for Development of Sporadic Retinoblastoma

2,4-Nonadienal and Benzaldehyde Bioantimutagens in Fushimi Sweet Pepper (Fushimi-Togarashi)

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