Bio-adhesive catechol-modified chitosan wound healing hydrogel dressings through glow discharge plasma technique

Sun, Chengyuan; Zeng, Xiaodong; Zheng, Shihang; Wang, Yulan; Li, Zhiyu; Zhang, Haining; Nie, Lanlan; Zhang, Yufeng; Zhao, Yufang; Yang, Xiangliang

doi:10.1016/j.cej.2021.130843

Cited by 91 publications

(51 citation statements)

References 54 publications

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“…Compared to conventional wound dressings, such as gauze and films, bioadhesive hydrogels are biologically more compatible and can be removed more easily from the wound. The bioadhesive property can be provided to the hydrogel dressings by modification with polyphenol derived moieties, such as catechol, dopamine, gallic acid, or tannic acid [ 51 , 52 , 58 , 79 , 80 ].…”

Section: Functional Hydrogels For Chronic Wound Healingmentioning

confidence: 99%

“…The degree of adhesiveness can be tailored with the extent of chemical modifications of polyphenol derived moieties to meet the demands of the particular wound type. Highly adhesive hydrogel dressings were found to be beneficial for shallow and small chronic wounds while less adhesion was preferred for deep and large chronic wounds [ 58 ]. For example, Sun et al performed gallic acid (GA) modification to chitosan (CS-GA) ( Figure 2 A) with different amounts of grafting (CS-GA1 < CS-GA2 < CS-GA3) [ 58 ].…”

Section: Functional Hydrogels For Chronic Wound Healingmentioning

confidence: 99%

“…Highly adhesive hydrogel dressings were found to be beneficial for shallow and small chronic wounds while less adhesion was preferred for deep and large chronic wounds [ 58 ]. For example, Sun et al performed gallic acid (GA) modification to chitosan (CS-GA) ( Figure 2 A) with different amounts of grafting (CS-GA1 < CS-GA2 < CS-GA3) [ 58 ]. The final product CS-GA was highly biocompatible, adhesive, and stretchable ( Figure 2 B).…”

Section: Functional Hydrogels For Chronic Wound Healingmentioning

confidence: 99%

“…and ( D ) ROS scavenging performance based on the amount of GA grafting ( E ) Antimicrobial activity of CS, GA, and CS with different GA contents (G1 < G2 < G3) against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S.A. ). Reproduced with permission [ 58 ]. Copyright 2022 Elsevier.…”

Section: Figurementioning

confidence: 99%

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Functional Hydrogels for Treatment of Chronic Wounds

Firlar

Altunbek

McCarthy

et al. 2022

Gels

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Chronic wounds severely affect 1–2% of the population in developed countries. It has been reported that nearly 6.5 million people in the United States suffer from at least one chronic wound in their lifetime. The treatment of chronic wounds is critical for maintaining the physical and mental well-being of patients and improving their quality of life. There are a host of methods for the treatment of chronic wounds, including debridement, hyperbaric oxygen therapy, ultrasound, and electromagnetic therapies, negative pressure wound therapy, skin grafts, and hydrogel dressings. Among these, hydrogel dressings represent a promising and viable choice because their tunable functional properties, such as biodegradability, adhesivity, and antimicrobial, anti-inflammatory, and pre-angiogenic bioactivities, can accelerate the healing of chronic wounds. This review summarizes the types of chronic wounds, phases of the healing process, and key therapeutic approaches. Hydrogel-based dressings are reviewed for their multifunctional properties and their advantages for the treatment of chronic wounds. Examples of commercially available hydrogel dressings are also provided to demonstrate their effectiveness over other types of wound dressings for chronic wound healing.

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Section: Functional Hydrogels For Chronic Wound Healingmentioning

confidence: 99%

Section: Functional Hydrogels For Chronic Wound Healingmentioning

confidence: 99%

Section: Functional Hydrogels For Chronic Wound Healingmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

Functional Hydrogels for Treatment of Chronic Wounds

Firlar

Altunbek

McCarthy

et al. 2022

Gels

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“…Various bioadhesive bandages have been developed to improve drug delivery to the wound site. 38,39 Chitosan and poly(acrylic acid) are among them and they possess extensive mucoadhesive properties. 40,41 Adhesion to skin occurs when hydrogen bonds from poly(acrylic acid) react with the mucosa, while negatively charged surfaces and cells interact electrostatically with positively charged chitosan molecules.…”

Section: A Bioadhesivenessmentioning

confidence: 99%

Leveraging the advancements in functional biomaterials and scaffold fabrication technologies for chronic wound healing applications

et al. 2022

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An Injectable Self‐Crosslinked Wholly Supramolecular Polyzwitterionic Hydrogel for Regulating Microenvironment to Boost Infected Diabetic Wound Healing

Pang

Wang

Yao

et al. 2023

Adv Funct Materials

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It is highly desirable yet significantly challenging to fabricate injectable, self‐crosslinked, self‐fused, and antifouling polyzwitterionic hydrogels, whose successful preparation will expand their application scope in biomedical fields. Herein, for the first time, a novel zwitterionic monomer, carboxybetaine urethane acrylate (CBUTA) is designed and synthesized with a urethane group and zwitterion on the same side chain. The strong inter‐urethane H‐bonds and zwitterionic dipole–dipole interactions of side chains contribute to self‐crosslinked wholly supramolecular polyzwitterionic hydrogel that is directly formed from photoinitiated polymerization of CBUTA aqueous solution without adding any chemical crosslinkers. After being swollen in water, the polyCBUTA (PCBUTA) hydrogel is squeezed into small particles and freeze‐dried to obtain hydrogel powder. The injectable and wholly zwitterionic supramolecular PCBUTA hydrogel can be easily reconstructed by mixing hydrogel powder with water due to the recombination of H‐bonds of urethane groups and zwitterionic dipole–dipole interactions. The re‐formed PCBUTA hydrogel exhibits an excellent self‐fused and antifouling ability, and this injectable PCBUTA hydrogel, endowed with a microenvironment‐regulated function, demonstrates excellent glucose consumption, antioxidation, antibacterial, and angiogenesis ability, thus accelerating the infected diabetic wound healing. Overall, this work provides a promising strategy to develop injectable and wholly zwitterionic hydrogels that will find broad biomedical applications.

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Bio-adhesive catechol-modified chitosan wound healing hydrogel dressings through glow discharge plasma technique

Cited by 91 publications

References 54 publications

Functional Hydrogels for Treatment of Chronic Wounds

Functional Hydrogels for Treatment of Chronic Wounds

Leveraging the advancements in functional biomaterials and scaffold fabrication technologies for chronic wound healing applications

An Injectable Self‐Crosslinked Wholly Supramolecular Polyzwitterionic Hydrogel for Regulating Microenvironment to Boost Infected Diabetic Wound Healing

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