Bio-acceptable 0D and 1D ZnO nanostructures for cancer diagnostics and treatment

Ortiz-Casas, Brandon; Galdámez‐Martínez, Andrés; Gutiérrez-Flores, Jorge; Ibañez, Andrés Baca; Panda, Pritam Kumar; Santana, G.; Vega, Horacio Astudillo de la; Suar, Mrutyunjay; Rodelo, Citlaly Gutiérrez; Kaushik, Ajeet; Mishra, Yogendra Kumar; Dutt, A.

doi:10.1016/j.mattod.2021.07.025

Cited by 101 publications

(50 citation statements)

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“…As Lingervelder et al have reviewed, for general practitioners, the clinical utility of POC testing is the most critical aspect [ 65 ]. To ensure POCT’s usefulness to clinicians, future research [ 74 ], despite focusing on the analytical and technical performances of a test, should also tackle the aspects relating to the clinical utility and risks [ 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ]. Moreover, in the case of smartphone-connected POCT devices, the issues related to data sensitivity, including privacy and protection against theft and medical advice, should be addressed [ 69 ].…”

Section: Challenges and Perspectives Towards Poc Diagnostics Of Damentioning

confidence: 99%

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Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics

2021

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Parkinson’s disease (PD) is a neurodegenerative disease in which the neurotransmitter dopamine (DA) depletes due to the progressive loss of nigrostriatal neurons. Therefore, DA measurement might be a useful diagnostic tool for targeting the early stages of PD, as well as helping to optimize DA replacement therapy. Moreover, DA sensing appears to be a useful analytical tool in complex biological systems in PD studies. To support the feasibility of this concept, this mini-review explores the currently developed graphene-based biosensors dedicated to DA detection. We discuss various graphene modifications designed for high-performance DA sensing electrodes alongside their analytical performances and interference studies, which we listed based on their limit of detection in biological samples. Moreover, graphene-based biosensors for optical DA detection are also presented herein. Regarding clinical relevance, we explored the development trends of graphene-based electrochemical sensing of DA as they relate to point-of-care testing suitable for the site-of-location diagnostics needed for personalized PD management. In this field, the biosensors are developed into smartphone-connected systems for intelligent disease management. However, we highlighted that the focus should be on the clinical utility rather than analytical and technical performance.

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Section: Challenges and Perspectives Towards Poc Diagnostics Of Damentioning

confidence: 99%

“…Biosensors 2021, 11, x FOR PEER REVIEW 10 of 14 risks[75][76][77][78][79][80][81][82][83]. Moreover, in the case of smartphone-connected POCT devices, the issues related to data sensitivity, including privacy and protection against theft and medical advice, should be addressed[69].…”

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confidence: 99%

Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics

2021

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“…Tumor gaseous biomarkers are volatile organic compounds (VOCs) produced by cancer cells mainly as a result of cell metabolic process alterations [ 3 ] and cell plasma membrane peroxidation [ 4 ]. The identification of VOCs exhaled by human body fluids (as urine [ 5 , 6 , 7 ], breath [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ], blood [ 16 , 17 ], and feces [ 18 , 19 ]), exploiting a low invasive technique, is crucial to detect tumor formations, minimizing the collateral effects and injuries to the patients [ 20 , 21 , 22 , 23 , 24 ]. In previous studies of this research team, patented devices based on nanostructured chemoresistive gas sensors technology, developed in Laboratorio Sensori of the University of Ferrara, have been designed and manufactured to analyze feces exhalation for colorectal cancer (CRC) screening, blood exhalations for tumor post-surgical and post-treatment monitoring, and CRC tissue exhalations [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Chemoresistive Sensors for Cellular Type Discrimination Based on Their Exhalations

et al. 2022

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The detection of volatile organic compounds (VOCs) exhaled by human body fluids is a recent and promising method to reveal tumor formations. In this feasibility study, a patented device, based on nanostructured chemoresistive gas sensors, was employed to explore the gaseous exhalations of tumoral, immortalized, and healthy cell lines, with the aim of distinguishing their VOC patterns. The analysis of the device output to the cell VOCs, emanated at different incubation times and initial plating concentrations, was performed to evaluate the device suitability to identify the cell types and to monitor their growth. The sensors ST25 (based on tin and titanium oxides), STN (based on tin, titanium, and niobium oxides), and TiTaV (based on titanium, tantalum and vanadium oxides) used here, gave progressively increasing responses upon the cell density increase and incubation time; the sensor W11 (based on tungsten oxide) gave instead unreliable responses to all cell lines. All sensors (except for W11) gave large and consistent responses to RKO and HEK293 cells, while they were less responsive to CHO, A549, and CACO-2 ones. The encouraging results presented here, although preliminary, foresee the development of sensor arrays capable of identifying tumor presence and its type.

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“…However, like other nanostructured MOSs, these sensors have some limitations. To further improve the sensing performance, surfaces of ZnO nanowires can be decorated with noble metal nanoparticles 12–14 . The catalytic effect of noble metal nanoparticles enhances the adsorption of gas molecules onto the ZnO nanowires, resulting in improved gas‐sensing performance.…”

Section: Introductionmentioning

confidence: 99%

“…To further improve the sensing performance, surfaces of ZnO nanowires can be decorated with noble metal nanoparticles. [12][13][14] The catalytic effect of noble metal nanoparticles enhances the adsorption of gas molecules onto the ZnO nanowires, resulting in improved gas-sensing performance. Lupan et al fabricated Aumodified ZnO nanowires as hydrogen gas sensors with a sensing response of 10.6 for 200 ppm hydrogen gas.…”

Section: Introductionmentioning

confidence: 99%

AuPt bimetal‐codecorated ZnO nanowire‐based hydrogen sensors for detecting low concentration hydrogen gas with high response and selectivity

Min

Kim

et al. 2022

Bulletin Korean Chem Soc

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ZnO nanowires decorated with bimetallic AuPt nanoparticles were synthesized using the vapor-liquid-solid method, followed by sputtering and thermal annealing, to fabricate highly sensitive and selective sensors for detecting ppb scale hydrogen gas. The proposed sensor demonstrated a clear pattern enough to recognize, even for 100 ppb hydrogen gas. The sensing responses of the pristine and AuPt bimetal-codecorated ZnO nanowire-based sensors were 1.09 and 7.3 for 100 ppb hydrogen gas, respectively. The sensing response of the proposed sensor is seven times as the decoration of AuPt nanoparticles. Furthermore, the proposed sensor exhibited excellent sensing selectivity for various interfering gases including ethanol, acetone, toluene, CO, and H 2 S. The proposed sensor shows excellent sensing performance because of synergistic effect of decorated AuPt, which play the role of catalysts. Therefore, hydrogen sensors showing superior sensing performance can be fabricated using this nanomaterial, and its advanced sensing performances are analyzed in this study.

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Bio-acceptable 0D and 1D ZnO nanostructures for cancer diagnostics and treatment

Cited by 101 publications

References 509 publications

Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics

Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics

Chemoresistive Sensors for Cellular Type Discrimination Based on Their Exhalations

AuPt bimetal‐codecorated ZnO nanowire‐based hydrogen sensors for detecting low concentration hydrogen gas with high response and selectivity

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